Báo cáo y học: "Bench-to-bedside review: Fulfilling promises of the Human Genome Project" pot

... [2–5]. The draft sequence of the human genome, recently published by the Human Genome Projectpublic consortium [6] and by a private company [7], repre-sents a milestone in science. Today, the ... human is nearly completed and covers 96% of the genome. Embedded within our genomes are the sequences of the approximately 30,000 genes that underlie human biology andmedicine. As we enter the ... areproducible fashion. Therefore, comprehensive studies willrely on the development of fast and efficient tools to identify the small number of relevant SNPs out of the millions in the human genome. A phenomenon...

Báo cáo y học: "A comprehensive transcript index of the human genome generated using microarrays and computational approaches" pdf

... http://genomebiology.com/2004/5/10/R73 Genome Biology 2004, 5:R73Background The completion of the sequencing of the human, mouse andother genomes has enabled efforts to extensively annotatethese ... Escherichia coli genomes. The recent sequenc-ing and analysis of the mouse genome indicates extensivehomology between intergenic regions of the human andmouse genomes, further highlighting the potential ... highlighted the limitations of rely-ing solely on computational approaches to identify genes in the draft of the human genome [8-13]. Furthermore, substan-tial experimental data from direct assays of...

Báo cáo Y học: Puri®cation and characterization of the human adenosine A2a receptor functionally expressed in Escherichia coli doc

... cally to the XAC-agarose.Theophylline was removed by gel ®ltration before quanti-fying speci®c [3H]ZM241385 binding in the X AC-agaroseeluate. The value obtained was only 50±80% of the theoretical ... concentrations of 10±20times their Kivalue. Without ligand, a half-life of 33 dayswas obtained. This increased to 77 days in the presence of NECA (agonist) and 53 days in the presence of theophylline(antagonist) ... weveri®ed the identity of the hA2aR fusion protein by speci®cradioligand binding (see below), N-terminal sequencing andamino-acid analysis. The sequence obtained, namely Lys-Ile-Glu-Glu-Gly-Lys-Leu-Val-Ile-Trp...

Báo cáo y học: " A standard variation file format for human genome sequence" pot

... describing the frequency of the variant in a population. The details of the source of the frequency should be described in an attribute-method pragma asdiscussed above. The order of the values ... Optional The total number of reads covering a variantTotal_reads = 57;Genotype String Optional The genotype of this variant, either heterozygous, homozygous, or hemizygousGenotype = heterozygous;Variant_freq ... phenotype or both.##phenotype-description Ontology = http://www .human- phenotype-ontology.org /human- phenotype-ontology.obo.gz;Term = acute myloid leukemia;Comment = AML relapse;ploidy Ontology,...

Báo cáo y học: " Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene" pdf

... The number of HMBOX1 RNAs on the transcription spots before and after Tat-EGFP transfection is shown. C) The ratio between the intensity of the hybridization signals on the transcription spots ... amount of RNA on the transcription spot is determined by the rate of transcrip-tion and the rate of RNA processing. At steady state itcould be derived from the intensity of the fluorescence ... is the processing of the RNA; both contribute to the level of RNA at the site of transcription at steady state [35].It is however unlikely that detection was lowered by scarceaccessibility of...

Báo cáo y học: " A reaction-diffusion model of the receptor-toxinantibody interaction" pot

... evaluation of protective potential of an antibodyand for the estimation of the time period during which the application of this antibodybecomes the most effective.Theselectionoftherateconstantsfornumerical ... correspond to the scenario of binding of ricin to receptor and to the antibody then for the toxin concentra-tion T = 10 pM the reaction time is of order of 10 s. By further increasing the toxin ... transport.Conclusions: The proposed refinement of the RTA model may become importantfor the consistent evaluation of protective potential of an antibody and for the estimation of the time period during which the...

Báo cáo y học: "Fast-evolving noncoding sequences in the human genome" pps

... This hypothesis is strengthened by the recent study conducted by Pollard and coworkers [18],because 112 out of the 202 HARs overlap the power CNCsequences of the present study. The overlap of ... study butmainly due to the fact that our analysis makes the explicitassumption that the human lineage is significantly faster thanthat of the chimpanzee, which is not the case in the study con-ducted ... curation confirms that this only potentiallyoccurs in fewer than 3% of cases. The lower quality of the other two genomes has minimal effect on the human ANCsequence analysis, because for a substitution...

Báo cáo y học: "Getting a buzz out of the bee genome" pot

... many alleles; heterozygous zygotes develop as females,hemizygous or homozygous zygotes develop as males [7].This hypothesis was confirmed for honey bees by Woyke [8]and the complementary sex ... parthenogeneticallyfrom unfertilized eggs [5]. The study of the genetic basis of this mechanism of sex determination in honey bees had toawait the development of artificial insemination; otherwiseit ... laying eggs. The genome sequence of the honey bee will provide a valuable resource for the detailedanalysis of differences in gene expression between thesecastes. Early data from relatively...

Báo cáo y học: "Genetics and genomics converge on the human blood fluke" potx

... lack of genomic resourcesto develop useful genome- wide markers, the life cycles of this group of parasites, which do not easily allow the genotyping and phenotyping of individual progeny fromcrosses ... 55::203.http://genomebiology.com/2009/10/6/225 Genome BBiioollooggyy2009, Volume 10, Issue 6, Article 225 Tait 225.3 Genome BBiioollooggyy 2009, 1100::225 Genome BBiioollooggyy 2009, 1100::225MinireviewGGeenneettiiccss ... a.tait@vet.gla.ac.ukAAbbssttrraacctt The construction of a genetic map of the human infective blood fluke (Schistosoma mansoni),coupled with the availability of the genome sequence, offers new approaches...

Báo cáo y học: " Large infrapatellar ganglionic cyst of the knee fat pad: a case report and review of the literature" potx

... mostly but not exclusively for clinical physicians and radiologists.IntroductionCystic lesions around the knee are common. Of these,popliteal cysts are the most frequently encountered.Other cystic ... half of the pati ents had no otherabnormality. The differential diagnosis of knee cystic lesions mustinclude ganglia, lipoma, synovial myxoma, meniscal orparameniscal cyst, synovial cysts, ... upon, the preservation of an intact synovium should be the main consideration of t he surgeon. Unfortunately, inour patient, the preservation of an intact synovium wasinevitable because of the...

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