... Robert Galle1 and Werner Mayet41Department of Medicine, University of Mainz, Mainz, Germany2Institute of Pathology, University of Mainz, Mainz, Germany3Institute of Pathology, Professional ... epiphenomenon[10]. One of the unresolved issues is the inability toexplain the nonrandom, selected organ injury that defines the WG vasculitis and the concurrent, seemingly random,nature of injury within ... tissue and is upregulated in lung tissue of patients with WG. Interestingly, the parenchymal cells(pneumocytes type I and II) and macrophages, and not the neutrophils, express PR-3 most stronglyand...