Báo cáo y học: " Reviewing the reviewers: the vague accountability of research ethics committees" doc

... ensure adequacy of the REC Commentary Reviewing the reviewers: the vague accountability of research ethics committees Randi Zlotnik Shaul Bioethicist, Department of Bioethics, The Hospital for ... and professional trust in the ethics of human research and in REC review of protocols, it is imperative that steps be taken to clarify the accountability of...

Ngày tải lên: 12/08/2014, 18:21

... sequences may c onvey effector speci®city, whereas the Switch I and II domains primarily convey sensitivity t o the binding of GTP [8]. There is support f or this view from the crystal structure of the ... could therefore play a role in the fusion of these vesicles with the plasma membrane [45]. Binding of guanine nucleotides and hydrolysis of GTP by GST±Rab31 and GST±Ra...

Ngày tải lên: 08/03/2014, 16:20

... is the number of bases covered in a 300- bp window on the left (Figure 6), lavg is the average read coverage on the left, max_avg is 300, lgap is the length of any gap on the left, rate is the ... between the number of supporting mate pairs and the number of contradicting reads, |lavg - ravg| is a penalty for expres- sion differences on either side of the fusion,...

Ngày tải lên: 09/08/2014, 23:20

... inducing the expression of many pro-inflammatory genes. Inhaled glucocorticoids exert their anti-inflammatory effects through a wide variety of mech anisms, of which inhibition of NF-B is one of the most ... pro-inflammatory effects of resistin are partly mediated through activation of the NF-B pathway[14].Thereforeresistinmayhavearoleasa factor or a predictor in steroid...

Ngày tải lên: 11/08/2014, 03:20

... YM, KH, KY, CY and MK designed of the study. YK played a major role in the acquisition, analysis and inter- pretation of data and drafted the manuscript. KH made CGRP-adenovirus vector. YK, YM, ... (ERK) pathway is a critical pathway involved in the proliferation of many cell types including alveolar epithelial cells. On the basis of our hypothesis that CGRP proliferates alv...

Ngày tải lên: 12/08/2014, 14:20

... detection of the PCR product was monitored by measuring the increase in fluorescence caused by the binding of SYBR Green to dsDNA. Using 5 μl of cDNA, 5 μl of primer, and 10 μl of SYBR Green ... [45]. Finally, our data suggest that the effects of (R)-albuterol may be mediated by alterations in the activity of the inflammatory transcription factor NF-κB. NF-κB regulat...

Ngày tải lên: 12/08/2014, 15:21

... toxicity of hydroxyethyl starch is indeed a subject of ongoing research in human septic shock and the current experimental observations may further fuel these eff orts [13-15]. For instance, the ... Association of Critical- Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clin...

Ngày tải lên: 13/08/2014, 20:21

... about mortality in a complex emergency Are the results of the study valid? Primary guides • Is the regional distribution of the sample studied suffi- ciently representative of the underlying population? • ... through the following three questions. 1) Are the results of the study valid? This question considers whether the mortality estimates reported in the article...

Ngày tải lên: 25/10/2012, 10:31

... copy owing to incomplete bowel preparation. The bleeding was controlled by #3-0 Vycryl intracorporeal suture, and the invagination of the diverticulum was performed laparoscopically. The ... recovery was une- ventful, and the patient was discharged on postoper- ative day 4. Fig.1 Fluid collection and left ovary cyst was noted on computed tomography. The size of ovary...

Ngày tải lên: 25/10/2012, 10:51

... risk may be the preferred treatment because of the documented effi- cacy of the agent either in general, or in a particular patient. This paper will perform a selective review of the psycho- tropic ... risk of type 2 diabetes mellitus, dyslipidemia, hypertension, stroke, ischemic heart disease and early mortality [6-9]. The authors concluded that the preva- lence of obes...

Ngày tải lên: 25/10/2012, 10:51