Báo cáo y học: "Pro/con clinical debate: Is high-volume hemofiltration beneficial in the treatment of septic shock" docx

... precision for the high volumes involved. Certainly, the risk of discrepancybetween what is prescribed and what is delivered is increased,potentially leading to dosing errors. Furthermore, the metabolicconsequences ... but you are unsure whether you should try it.CommentaryPro/con clinical debate: Is high-volume hemofiltration beneficial in the treatment of septic shock?Karl Reiter*, Rinaldo Bellomo†, Claudio ... with sepsis [8]. However, care of the critically ill is notonly guided by evidence of effectiveness for achieving clinical endpoints [18]. Importantly, intensivists must also manipulatephysiologic...

Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps

... and bradykinin synthesis, since HAinhibited their synthesis in a MW-dependent manner [16].Further, HA has been shown to induce analgesia in abradykinin-induced model of joint pain in rats ... the proinflammatorycytokines IL-1 and TNF-α [29–31,36]. NO may be involved in cartilage catabolism by inhibiting the synthesis of colla-gen and PG, enhancing MMP activity, reducing the synthe-sis ... of many MMPs increases in OA by either an increase in theirown synthesis, an increased activation by their proen-zymes, or decreased activity of their inhibitors [29]. Pro-inflammatory cytokines,...

Báo cáo khoa học: " Inverse planned stereotactic intensity modulated radiotherapy (IMRT) in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment" potx

... controlled now. Including these 2 patients in the analysis of the 3-year-progression-free survival this is increased to 48% according to Kaplan-Meier. Unfortu-nately, 5 patients died of their disease ... 6months including clinical examination and MRI scans.Depending on clinical and radiological findings the period between individual follow-ups was increased after the second year. The measurement of ... justify-ing further investigations. Furthermore describes the IBRTconcept a promising approach to escalate the dose furtherwhile reducing the treatment time.A prospective study investigating the...

Báo cáo y học: "A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects" ppsx

... Despite these advances, most surgical inter-ventions only result in improvement in clinical symptoms, suchas pain relief, and the regeneration of long-lasting hyalinecartilage repair tissue remains ... reportedhave included periosteal hypertrophy, ablation, uneven celldistribution, and loss of cells into the joint cavity [15,16],resulting in repetition of surgery in up to 25% to 36% of patients ... andsynthetic biomaterials. Clinically significant and satisfactory resultsfrom applying autologous chondrocytes seeded in fibrin within abiodegradable polymeric material were recently reported....

Báo cáo y học: "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663" docx

... progression of stage specificmiRNA profiles in the mouse B2 B cell lineage. Blood 2011.13. Calin GA, Pekarsky Y, Croce CM: The role of microRNA and other non-coding RNA in the pathogenesis of chronic ... expres-sion of miR-663 is higher in M1 than M5 AML patientsand hypothesized it may potentially be involved in blocking the differentiat ion of M1 blasts, and conse-quently monocytic differentiation ... determined using a microRNA microarray as described in the materials and methods (A) significance analysis of microarrays of differentially regulated microRNAs in ATRA treated cells. (B) List of...

Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx

... pain by inducing the synthesis of inflammatorycytokines and other neuroactive molecules [42]. Adminis-tration of the p38 inhibitor SB203580 intrathecally pre-vents spinal nerve ligation-induced ... pain model. The inhibitory effect of the p38 inhibitors on joint degenera-tion in the iodoacetate model in the present study is in the range of the inhibitory effect of MMP inhibitors tested in this ... approveddisease modifying drugs for the treatment of OA.A number of protein kinases including the MAPKs havebeen implicated in the induction and maintenance of pain sensitization. P38 is activated in...

Báo cáo y học: "Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study" potx

... blocking agents.Competing interests The authors declare that they have no competing interests.Authors' contributionsFA and MC participated in the design of the study and in the clinical ... be pointed out that thesepatients did not display the same clinical characteristics as the patients with RA selected for the adalimumab treatment. More-over, they were already receiving treatment ... included and displayed a stable clinical course of the disease. It is therefore likely that a possible decrease in anti-body titer could have already taken place, with no additionaleffect of...

Báo cáo y học: "Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program" pptx

... means of informing the longer-term feasibility and sustainability of the program is also discussed.Summary: The NCCCP is a major systems-level set of organizational innovations to enhance clinical ... andsustainability. Each NCCCP pilot site is currently engaged in the initial phases of its implementation, assessing anddefining the innovation within the cultural context of the implementing organization, ... multi-level systems interventions will play in improving health,both in clinical research and in clinical care. Federalresearch institutions are scrutinized and criticized for the limited existing initiatives...

Báo cáo y học: " All that glitters is not gold - founder effects complicate associations of flu mutations to disease severity" ppt

... which is at a struc-tural position where the mutated sidechain is pointingaway from the functionally important cap binding site of the PB2 5’ cap snatching domain (Figure 3). The muta-tion is ... approach 1. This confirms theirsporadic and clade-independent nature in the phylogeny.On the other hand, the index ratios and monophyleticclade size statistics indicated that the 3 mutations ... to essentially all parts of the world. In the course of its evolutio n, the virus acquired many mutations, some of which have beeninvestigated in the context of increased severity due to high...

Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk for gastric atrophy. The ... that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the ... This study investigated the associations of Grb2 associated binder 1 (Gab1) polymorphism and the combination of PTPN11 gene encoding src homology 2 domain-containing protein tyrosine phosphatase-2...

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