Báo cáo y học: " Venous thromboembolism deserves your attention" pdf

... not consider mechanical prophylaxis at all. It has been strongly suggested, however, that elastic stockings should be Commentary Venous thromboembolism deserves your attention Charles Marc Samama Department ... result, physicians are often lulled into an inappropriate sense of security. Moreover, the diagnosis is not always easy to confirm. The insensitivity of Doppler ultrasound and...

Ngày tải lên: 12/08/2014, 18:21

... economy of oxygen in terms of supply (systemic oxygen transport), demand (oxygen consumption), or functional reserve (mixed venous oxygen content) [1]. Several authors advocate the use of venous ... regarding oxygen therapy in neonates rely primarily on measurements of arte- rial oxygen tension (PaO 2 ) and arterial oxygen saturation (SaO 2 ). This approach fails to describe fully the phy...

Ngày tải lên: 12/08/2014, 18:20

... imbalance between myocardial oxygen supply and demand resulting in EKG evidence of myocardial ischemia. An approach to the myocardial oxygen balance is off ered by the product systolic arterial ... SaO 2 = arterial oxygen saturation, ScvO 2 = central venous oxygen saturation, SvO 2 = mixed venous oxygen saturation, VO 2 -DO 2 = whole body oxygen uptake-to-delivery. Competing in...

Ngày tải lên: 13/08/2014, 20:21

... disulfide bonds formed by the six cysteine residues (Figs 1 and 6). Thus in BACE2, the three disulfide bonds are assumed to be Cys233–Cys433, Cys292–Cys457, and Cys344–Cys393. Such a disulfide bond ... stability, the presence/absence of the C-tail apparently affects the substrate specificity of the enzyme. Indirectly, the rigidity associated with the C-tail, particularly the two disulfide bonds, m...

Ngày tải lên: 17/03/2014, 10:20

... carried out by kinases, which are themselves frequently acti- vated by phosphorylation by upstream molecules. This specifically involves the attachment of a phosphate molecule, donated by intracellular ... Function in Regulating Exocytosis The family of scaffolding proteins, ␤-arrestins, may be required for activating signalling pathways leading to exocytosis of primary and secondary granules...

Ngày tải lên: 08/08/2014, 21:20

... antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 1999, 189:1639-1648. 7. Lipsky PE: Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. ... with B lymphocyte depletion. Ann Rheum Dis 2002, 61:883-888. 17. Leandro MJ, Edwards JC, Cambridge G, Ehrenstein MR, Isenberg DA: An open study of B lymphocyte depletion in systemic lupus erythe...

Ngày tải lên: 09/08/2014, 01:21

... activation Cysteinyl leukotrienes Vascular permeability, immunomodulatory (LTC 4 ) Cytokines/chemokines IL-1 Leukocyte recruitment, fibroblast/chondrocyte activation, angiogenesis IL-2 Lymphocyte stimulation IL-3 ... cells and the synovial mesenchyme The synovial mesenchyme, consisting principally of synovial fibroblasts, is prominently involved in joint inflammation. Fibroblasts increase gre...

Ngày tải lên: 09/08/2014, 01:24

... from both academia and industry, were brought together to discuss plant pathogen genomics at the British Society for Plant Pathology’s annual Presidential meeting, hosted by this year’s president, John ... Pseudomonas syringae pv. tomato DC3000 of specific effectors of the pathogen’s type III secretion system; this effectively converts a virulent pathogen to avirulence. John Mansfield (Imperi...

Ngày tải lên: 09/08/2014, 20:21

... with surprising frequency, a method that can rapidly and reliably link human genes to non-obviously related phenotypes in model systems offers the prospect of radically accelerating the rate ... introduction of therapies by years [9]. Human disease models and phenotypic connections in surprising places Recent work from Edward Marcotte’s laboratory by McGary et al. [6] takes these concept...

Ngày tải lên: 09/08/2014, 20:21

... Brockmann JH: What is bet-hedging? In Oxford Surveys in Evolutionary Biology. Volume 4. Edited by Harvey PH, Partridge L. Oxford: Oxford University Press; 1987:182-211. 3. Ratcli WC, Denison RF: ... genes involved in asymmetric division, particularly those regu- lated by CtrA, which upregulates many genes involved in cell division, reveal a conserved mechanism of cell cycle control in S...

Ngày tải lên: 09/08/2014, 22:23