... is synthesized by the liver and endothelium, and protein C by the liver. On the contrary, the tPA–PAI-1 complex is considered to besynthesized mainly by the activated endothelium, because the ... activator plasminogen activator inhibitor-1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreasMasami Hoshino*, Yoshikura Haraguchi†, Hiroyuki Hirasawa‡, ... related to the limited number of the patients in our study, or related to the origin of the parameters. PAI-1 is synthesized not only by the endothelium, but also by the liver, vascular smoothmuscle...