Báo cáo y học: " Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells" docx

... article Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells Gary R Hellermann, Szilvia B Nagy, Xiaoyuan Kong, Richard F Lockey and Shyam ... effects of cigarette smoke on NF κB activation. The purpose of this study was to gain insight into the mech- anism of inflammation induced by cigarette smoke...

Ngày tải lên: 12/08/2014, 18:20

... non-organized lymphoid aggregates (Figure 7). Since CXCL13, CCL19 and CCL21 are chemokines involved in the homeostatic trafficking of leukocytes, mainly lymphocytes, to the secondary and tertiary lym- phoid ... [4]. In nasal polyp disease, these t oxins are believed to drive the local immunoglobulin production in response to enterotoxin-producing S. aureus. Theuseofasingletoxininste...

Ngày tải lên: 12/08/2014, 13:22

... median and interquartile range * p < 0.05 ‡ p ≤ 0.01 Morphometry of pulmonary arteryFigure 2 Morphometry of pulmonary artery. Hematoxylin-eosin stained sections of main pulmonary artery (upper ... remodeling, Double elastic lamina presence in small intrapulmonary arter-iesFigure 3 Double elastic lamina presence in small intrapulmo- nary arteries. Orcein stain of small pulmona...

Ngày tải lên: 12/08/2014, 14:20

... observation that the EGFR tyrosine kinase inhibitor AG1478 blocks CSC- induced phosphorylation of ERK1/2 is in line with studies showing a role of EGFR in cigarette smoke induced epithe- lial cell ... cigarette smoke alone may partly explain the increased amount of prolif- erating cells observed in bronchial biopsies obtained from smokers [8], and may be relevant for our...

Ngày tải lên: 12/08/2014, 18:20

... normal function of AEC by a variety of mechanisms. Some of these include decreases in the level of exhaled NO, enhanced release of pro -inflammatory cytokines, and inhibition of the airway repair process ... including leukotrienes, prostaglandins and a variety of cytokines [7]. In the lungs and skin of smokers mast cells increase in absolute numbers and smoking may be a...

Ngày tải lên: 12/08/2014, 18:22

... chromosomes induce cortical actin and myosin II assembly into a distinct actincapsurroundedbyamyosinIIringintheMII eggs [6]. Interestingly, sperm chromatin incorporation at fertilization or m icroinjection ... protrusion, most likely by activating myosin II contractility [16]. Consistently, inhibition of myosin II contraction by using bl ebbistatin [17] or myo sin light chain kinase by ML-7...

Ngày tải lên: 13/08/2014, 18:21

... for Tk-G10S. Binding analysis of proteins to RNA ⁄ DNA hybrid Binding of the proteins to the substrate was analyzed using the Biacore X instrument (Biacore, Uppsala, Sweden). Twenty-nine bp [rA] 1 and ... relatively unstable or interactions with other proteins might be perturbed in human cells. Alternatively, the mutations in the acces- sory proteins may not have the same consequenc...

Ngày tải lên: 17/03/2014, 17:20

... inflammatory protein (MIP)-2 is one of its functional homologs [13]. In sepsis, the devel- opment of acute lung injury may be secondary to activa- tion of the inflammatory response. Sepsis syndrome ... endotoxemic rat. An increase in pulmonary vascular resistance or a decline in arterial oxygenation are the first indicators of acute lung injury [34]. Early in acute...

Ngày tải lên: 11/08/2014, 08:21

... during the course of the treatment. Pri- mary infections by CMV are accompanied by the appear- ance of a high response and frequency of specific CD4 pos T cells, which are maintained durably [18,21,36]. ... expanded in RA, because of TNF-α [27,28]. TNF-α has been demonstrated not only to play a prominent role in RA but also to diminish the intensity of the T-cell response [2...

Ngày tải lên: 12/08/2014, 14:22

... effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation. Clin Sci (Lond) 2008, 115:91-97. 31. Maines MD, Mayer RD, Ewing JF, McCoubrey WK ... Sekiguchi F, Kawabata A: Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase. Toxicology 2007, 241:92-97. 15. Ali MY, Ping CY, Mok YY, Ling L, Wh...

Ngày tải lên: 13/08/2014, 21:21