Báo cáo y học: "Genetic polymorphisms in lung disease: bandwagon or breakthrough?" ppt

... decline. All subjects were white and continued to smoke during the 5-year period of the LHS. These subjects were genotyped for polymorphisms in α1- antitrypsin, mEH, vitamin D binding protein, ... heme oxygenase-1 gene promoter may reduce the gene’s inducibility by reactive oxygen species in cigarette smoke, thus resulting in emphysema Cystic fibrosis HLA class II polymorphism in...

Ngày tải lên: 12/08/2014, 18:20

... common polymorphisms in DNA repair genes are continuously being identified, and these polymorphisms may play a pivotal role in sporadic carcinogenesis. A growing body of literature, including ... are important for maintaining DNA integrity and preventing carcinogenesis. Recent lung cancer studies have focused on identifying the effects of single nucleotide polymorphisms (SNPs...

Ngày tải lên: 31/10/2012, 14:59

... Piscataway, NJ) to yield high-quality DNA sufficient for single nucleotide polymorphism (SNP) genotyping. Single nucleotide polymorphism genotyping DNA was genotyped using Taqman SNP allelic discrimination on ... these polymorphisms with different RA phenotypes, we conducted analyses stratified by RF positivity, because many risk factors, including HLA-SE and cigarette smoking, have been sh...

Ngày tải lên: 09/08/2014, 10:23

... Huang YK, Chen YT, Hsueh YM: Urinary 8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic exposure area. Toxicol Appl Pharmacol 2008, 226:14-21. 19. Huang YL, Hsueh YM, Huang YK, Yip ... enzymes in porcine endothelial cells. Cell Mol Life Sci 2002, 59:1972-1982. 42. Brockmoller J, Cascorbi I, Kerb R, Roots I: Combined analysis of inherited polymorphisms in arylamine N-...

Ngày tải lên: 10/08/2014, 05:21

... Critical Care Medicine, University of Toronto, Canada 2 Intensive Care Unit, Mount Sinai Hospital, Toronto, Canada Corresponding author: Stephen E Lapinsky, Stephen.lapinsky@utoronto.ca Published: ... IEC standards, and that shielding, grounding and filtering, were not costly when incorporated into the initial device design [6]. Despite that, and in the face of growing evidence of EMI in...

Ngày tải lên: 13/08/2014, 08:20

... Program for the Training of University Professors of the Spanish Ministry of Education. AG was supported by the Instituto de Salud Carlos III (Spain). References 1. Harney S, Wordsworth BP: ... support to this hypothesis and will show how important it is to define the participation of each ECM protease in joint pathology before trying to manipulate them therapeutically. Competing interest...

Ngày tải lên: 09/08/2014, 07:20

... ZL, Qin YJ, He JW, Huang QR, Li M, Hu YQ, Liu YJ: Asso- ciation of polymorphisms in low-density lipoprotein receptor- related protein 5 gene with bone mineral density in postmenopausal Chinese ... [57] was not only an enormous leap forward in identifying that genes that underlie complex genetic disorders such as inflammatory bowel disease, ankylosing spondylitis, and type 1 diabetes....

Ngày tải lên: 09/08/2014, 10:23

... history depend critically on the patterns of variation represented not just by com- mon SNPs (minor allele frequency ≥0.05) contained in genotyping SNP panels, but also by rare variants (minor allele ... We also evaluated the haplotype diversity in each group by averaging the haplotype het- erozygosity in ten 10-kb non-overlapping windows and Figure 1 SNP discovery in Indian populatio...

Ngày tải lên: 09/08/2014, 22:23

... L, Maly FE, Zünd G, Turina M: Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass. ... present in 894G/T polymorphism eNOS activity may be impaired [5]. This polymorphism may also influence NO release of thrombocytes. We investigated the insertion/deletion pol- ymorphism in in...

Ngày tải lên: 10/08/2014, 10:20

... genotyped in the Doetinchem cohort for verification. FEV 1 decline in the Doetinchem cohort was calculated based on FEV 1 decline between the two surveys and genotype effects were tested using linear ... excess FEV 1 decline in males only. Of importance, this associa- tion was replicated in the Doetinchem cohort with a lar- ger genotype effect (-9.0 ml/yr and -4.2 ml/yr excess FEV 1 d...

Ngày tải lên: 12/08/2014, 13:22