Báo cáo y học: "α Tumour necrosis factor-α production in fibrosing alveolitis is macrophage subset specific" ppt

... future. Keywords: fibrosing alveolitis, haemolytic plaque, macrophages, monocytes, systemic sclerosis, tumour necrosis factor (TNF)-α Received: 29 March 2001 Revisions requested: 14 May 2001 Revisions ... bronchoalveolar lavage; CFA = cryptogenic fibrosing alveolitis; FA = fibrosing alveolitis; FASSc = fibrosing alveolitis associated with systemic sclerosis; Mo = peripheral b...

Ngày tải lên: 12/08/2014, 18:20

... two MAPKs. Introduction Chronic inflammation of the synovial membrane (synovitis) is a hallmark of rheumatoid arthritis (RA). This process is fueled by proinflammatory cytokines, which not only induce but also maintain synovitis ... reproduction in any medium, provided the original work is properly cited. Abstract Tumour necrosis factor (TNF) is considered to be a major factor...

Ngày tải lên: 09/08/2014, 07:20

... STAT1 is mainly activated by IFN-γ. Also, Cyp7b is not regulated by IFN-γ, as described previously [10]. Therefore, it is unlikely that STAT1 is involved in Cyp7b activity regulation. There is evidence ... NF-κB binding sites in the Cyp7b promoter. Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by hyperplasia of fibroblast-like synoviocy...

Ngày tải lên: 09/08/2014, 07:20

... etanercept. A few very early studies have also examined the effect of disease modifying drugs on bone loss in RA using older densitometric techniques like metacarpal morphometry. In a study of 70 patients, ... automated radiogrammetry. Moreoever, automated radiogrammetry using hand X-rays shows a strong correlation with BMD assessed by dual energy X-ray absorptiometry [13]. In summary,...

Ngày tải lên: 09/08/2014, 10:20

... Tremblay MJ: The low viral production in trophoblastic cells is due to a high endocytic internalization of the human immunodeficiency virus type 1 and can be overcome by the pro-inflammatory cytokines ... rep- lication in the placental tissue is important, since a shift in cytokine production towards a proinflammatory profile (notably TNF-α) has been associated with Plasmodium f...

Ngày tải lên: 13/08/2014, 09:20

... prevention of ankylosis in this chronic inflammatory disorder. A few years ago, rheumatologists treating patients with ankylosing spondylitis (AS) had to accept the fact that the only goal of their ... damage that is typical of this chronic inflammatory disorder. In the field of spondyloarthropathies (SpA), a group of diseases that present rheumatologically mainly with spondylitis, pauc...

Ngày tải lên: 09/08/2014, 06:23

... pulmonary disease (COPD) is characterized by a chronic inflammatory process, in which the pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-α is considered to play a role. In the present study ... polymorphism, Susceptibility, Tumor necrosis factor-α Introduction The pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-α plays an important role in inflammatory proces...

Ngày tải lên: 12/08/2014, 18:20

... in obesity-associated insulin resistance and diabetes, inhibit insulin signalling at several points in the signalling cascade. The liver is critical in maintaining cir- culating glucose levels and, in ... decreased responsiveness of the body to insulin (insulin resis- tance), accompanied by the failure of pancreatic b-cells to secrete insulin to counteract this insulin-resistant sta...

Ngày tải lên: 16/03/2014, 02:20

... µM bisindolylmaleimide [BIS] I, protein kinase C [PKC] inhibi- tor), or 2,3-bis(1H-indol-3-yl)-N-methylmaleimide (10 µM BIS V, inactive analog of BIS I), 1,4-diamino-2,3-dicyano- 1,4-bis(2-aminophenylthio)-butadiene ... pathways, cells were treated prior to addition of TNF-α or EGF with phar- macologic inhibitors including 2-[1-(3-dimethylaminopro- pyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleim...

Ngày tải lên: 09/08/2014, 06:22

... critically. HA was involved in perform- ing RT-PCR. BF was involved in F(ab')2 isolation. JB isolated PBMCs from healthy donors. BM revised the article critically. JLD was involved in the ... Wanigasekara Y, Bloomfield G, Wallach D, Roufogalis BD, Chaudhri G: A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is...

Ngày tải lên: 09/08/2014, 10:20