Báo cáo y học: "Genomic approaches to research in pulmonary hypertension" pot

... 1998, 52:44–49. Respiratory Research Vol 2 No 4 Geraci et al Available online http://respiratory -research. com/content/2/4/210 commentary review reports primary research factors, inflammatory mediators, or ... chronic hypobaric hypoxia. We conclude that PGIS plays a major role in modifying the pulmonary vascular response to chronic hypoxia. Additional data investigating the prostac...

Ngày tải lên: 12/08/2014, 18:20

... expression), oligonucleotide arrays, and cDNA arrays are new tools that allow investigators to measure the expression of thou- sands of genes in a single experiment. Experiments using such approaches are leading to additional ... genomics to classify cancers so far have been made with leukemia and lymphoma. A study of myelogenous and lymphocytic leukemias at Harvard with gene arrays...

Ngày tải lên: 12/08/2014, 18:20

... Met-tRNA binding to 40-S subunits U46751 P60 Phosphotyrosine 9.5 29.1 3.1 Ubiquitin-binding protein; binds SH2 domain of p56lck independent ligand p62 and ubiquitin; contains G-protein-binding region, ... and inflammatory response in JRA. Interestingly, several of the immunoregulatory genes that were up-regulated in patients are known to be induced by interferon γ (IFN-γ), including t...

Ngày tải lên: 09/08/2014, 01:23

... producing high local anti-inflammatory activity. The anti-inflammatory effi- cacy of Ciclesonide in these studies was similar to that produced by Fluticasone but with an improved safety profile, ... and clinical symposia. Presenta- Meeting report New approaches to the modulation of inflammatory processes in airway disease models: ATS 2001, May 18–23, San Francisco David J Hele Respi...

Ngày tải lên: 12/08/2014, 18:20

... enzymes from aggregating during drying, whereas the other copy encodes a protein that lacks this activity but instead associates with phospholipid bilayers and may protect their integrity during ... of anhydrobiosis in bdelloids is expected to lead to many DSBs and hence to many mitotic gene-conversion events that will sometimes lead to mitotic crossing-over. Bdelloids may be unusua...

Ngày tải lên: 14/08/2014, 08:20

... poly-ubiquitin-binding protein resin and followed this with denaturing Ni-chelate chromatography in order to purify ubiquitinated proteins from yeast cells expressing 6xHis-ubiquitin. Remarkably, ... 3 Activity-based profiling of deubiquitinating enzymes and interacting proteins. (a) Ubiquitin fused to an amino-terminal epitope tag (for example hemagglutinin, HA) and a carboxy-terminal...

Ngày tải lên: 14/08/2014, 14:22

... the drug either in the cytoplasm, for example, the inactivation of gentamicin by aminoglycoside-modifying enzymes, or in the periplasm, for example, the destruction of ␤- lactams by ␤-lactamase; ... mutation frequency apparently reduced to zero compared to the wild-type parent, when tested in a murine model of infection [1]. The gyrA mutations caused by ciprofloxacin-mediated induct...

Ngày tải lên: 14/08/2014, 16:20

... anonymity of their researchers and research centres in editorial offices of journals may constitute addi- tional barriers. Many researchers from LAMI countries are daunted by the seemingly insurmountable ... (Eugene B. Brody, Kathy McKnight), Lancet (Laragh Gollogly), Primary Care Psychiatry (Sean Lynch), Psychiatry: Interpersonal and Biological Processes (Robert Ursano), Psychiatry Rese...

Ngày tải lên: 08/08/2014, 20:23

... path- ways involved in cytokine/chemokine activity (cytokine- cytokine receptor interaction and Jak-STAT signalling), matrix remodelling (focal adhesion, TGF-β signalling, and ECM receptor interaction), ... inhibi- tion prevents proinflammatory cytokine-induced cartilage damage. Rheumatology (Oxford) 2002, 41:801-808. 12. Tak PP: Chemokine inhibition in inflammatory arthritis. Best Pract...

Ngày tải lên: 09/08/2014, 01:22

... Proinflammatory cytokines mediating burn- injury pain. Pain 2008, 135:98-107. 54. Geiss A, Varadi E, Steinbach K, Bauer HW, Anton F: Psychoneu- roimmunological correlates of persisting sciatic pain in patients ... of multiple types of stressors on the physiology and symptomatology of patients with RA. Collectively, laboratory research has docu- mented a maladaptively pro-inflammatory resp...

Ngày tải lên: 09/08/2014, 14:20