Báo cáo y học: "Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors" potx

... Chemo- transduction in the carotid body: K + current modulated by pO 2 in type I chemoreceptor cells. Science 1988, 241:580–582. 10. Youngson C, Nurse C, Yeger H, Cutz E: Oxygen sensing in airway chemoreceptors. ... study O 2 sensing in human Available online http://respiratory-research.com/content/2/3/145 Figure 1 Schematic flow diagram illustrating the diverse but converging...

Ngày tải lên: 12/08/2014, 18:20

... myopathy occurring after two doses of methylprednisolone. Typically, acute steroid myopathy occurs with therapy using intravenous corticosteroids at high doses. Acute myopathy developing very ... taking oral methylprednisolone for only two days, 24 mg on day 1 and 20 mg on day 2. He discontinued the medication because of new-onset myalgias and lethargy on day 3 and was seen in our cli...

Ngày tải lên: 11/08/2014, 00:22

... production in leukocytes was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val- Met-NH 2 (WKYMVM), or phorbol myristate acetate (PMA) and assessed by quantifying superoxide anion formed by the ... of demyelination and axonal injury, both in experimental autoimmune encephalomyelitis and MS [27,28]. How- ever, there is increas ing evidence for a protective role of innate immun...

Ngày tải lên: 11/08/2014, 03:20

... one year after he finished taking temozolomide. This should provide further insight into a possible toxicity profile of this alkylating agent. This finding should be of interest to physicians in ... unequivocally shown its therapeutic potential in randomized clinical trials as an effective, relatively safe, and generally well-tolerated therapy for aggressive CNS neoplasms, resulting in...

Ngày tải lên: 11/08/2014, 03:21

... may help in revealing the pathophysiology of this probably underdiagnosed syndrome. Appendix • Diagnostic criteria for classical Sweet’ssyndrome (originally proposed by Su and Liu in 1986 and ... characterized by a constellation of clinical symptoms and physical findings, w hich include fever, blood and tissue neutrophilia, leading to the development of ten- der, erythematous infl...

Ngày tải lên: 11/08/2014, 03:21

... PKC. These findings imply that the capacity of leukocytes to mount a respi ratory burst is of relevance to the severity of autoimmunity, as previously shown in monophasic GBS and in MS [10,11]. In t ... fol- lowing methods were used: enzyme-linked i mmunosor- bent assay (ELISA) for IgG and immunofluorescence (IF) assay of IgM antibodies against HSV (type 1 and 2), VZV and CMV; b...

Ngày tải lên: 11/08/2014, 06:22

... unequivocally shown its therapeutic potential in randomized clinical trials as an effective, relatively safe, and generally well-tolerated therapy for aggressive CNS neoplasms, resulting in better ... [6]. TMZ is an oral alkylating agent that is now known to be active against a var iety of CNS neoplasms. After oral absorption, it spontaneously hydrolyzes to methyltria- zen-1-yl imidazol...

Ngày tải lên: 11/08/2014, 07:20

... characterized by a constellation of clinical symptoms and physical findings, w hich include fever, blood and tissue neutrophilia, leading to the development of ten- der, erythematous inflammatory skin lesions ... sometimes in connection with certain underlying diseases (drug- induced Sweet’s syndrome) [2]. Irrespective of its cause, clinical and laboratory signs in Sweet’ssyndrome r...

Ngày tải lên: 11/08/2014, 07:20

... tissue. Finally, CO in cigarette smoke may have dampened the inflammatory response, especially in the early phase. After continuous smoking the damaging and irritating effects may prevail, giving ... smoking on both induction and resolution of the inflammatory response in exhaled air, induced sputum, blood and urine. We hypothesised that smoking of two cigarettes would induce an i...

Ngày tải lên: 12/08/2014, 18:21

... those in the control diaphragm. No inflammatory infiltrate or necrosis is seen. Stained with hematoxylin and eosin. (c) and (d) Stained with antibody specific for slow myosin, heavy chain. (e) and ... cleave actomyosin complexes [34,37], whereas the ubiquitin– proteasome pathway degrades the myofilament actin and myosin [20]. Lysosomal proteases and calpains play a significant rol...

Ngày tải lên: 13/08/2014, 18:22