Báo cáo y học: " Role of endothelin-1 in lung disease" potx

... inflammatory responses induced by carrageenan in the mouse model of pleurisy. Cytokine 2001, 13(3):162-168. 47. Utsunomiya I, Ito M, Oh-ishi S: Generation of inflammatory cytokines in zymosan-induced ... Thus, a key step in the pathogenesis of acute lung injury may be myosin light chain kinase activation by TNFα, leading to epithelial barrier dysfunction. There is extensive lite...

Ngày tải lên: 12/08/2014, 15:21

... tuberculosis remains to be established. In addition to its role in (myco)bacterial infections, CD14 may also play a role in the pulmonary host response against respiratory syncytial virus (RSV), ... TLR4 activation by other PAMPs including certain viral components [13, 14]. In the lung, binding of LPS to TLR4 is in uenced by a number of surfactant proteins (SP), includin...

Ngày tải lên: 13/08/2014, 20:21

... between Cyt f and plastocyanin and/or plasto- cyanin and photosystem I, and subsequently the nature of the interactions in the two lineages (hydrophobic in cyanobacteria, electrostatic in chloroplasts) ... thermodynamic analysis by laser-flash absorption spectroscopy of photosystem I reduction by plastocyanin and cytochrome c 6 in Anabaena PCC 7119, Synechocystis PCC 6803, and spin...

Ngày tải lên: 21/02/2014, 01:21

... main transcription factor regulating Th2 development, GATA-3. Another interesting and recent finding is that the lack of RUNX3 in a mouse model results in eosinophilic airway inflammation. Interestingly, ... previously identified by linkage in sibling pairs, and by thorough haplotype analysis narrowed it down to a single polymorphism (having excluded the remaining nine that showed ass...

Ngày tải lên: 09/08/2014, 01:23

... and interstitial fibrosis [56]. Proinflammatory cytokines in urinary obstruction TNF-α and IL-1 The prototypical pro-inflammatory cytokines, TNF-α and interleukin-1 (IL-1), play a major role in ... two N-terminal cysteines of CXC chemokines (or α-chemokines) are separated by one amino acid, C chemokines (or γ chemokines) has only two cysteines; one N-terminal cysteine and one cysteine...

Ngày tải lên: 11/08/2014, 03:20

... and interstitial fibrosis [56]. Proinflammatory cytokines in urinary obstruction TNF-α and IL-1 The prototypical pro-inflammatory cytokines, TNF-α and interleukin-1 (IL-1), play a major role in ... two N-terminal cysteines of CXC chemokines (or α-chemokines) are separated by one amino acid, C chemokines (or γ chemokines) has only two cysteines; one N-terminal cysteine and one cysteine...

Ngày tải lên: 11/08/2014, 06:22

... expressed in almost all organs in the body and are thought to play impor- tant roles in maintaining vital functions [1]. They are key players in sensory systems and respond to temperature, touch, pain, ... and intertriginous areas of the skin. Moreover, anti-staphylo- coccal treatment is effective against exacerbation of eczema in AD [24]. These findings suggest that binding of...

Ngày tải lên: 11/08/2014, 08:22

... nitrotyrosine (10 mM) to verify the binding specificity. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling assay Terminal deoxynucleotidyl transferase-mediated dUTP- biotin ... randomly divided as described above and monitored for loss of body weight and mortality for 7 days after zymosan or saline administration. Clinical scoring of systemic toxicity Clinical severi...

Ngày tải lên: 11/08/2014, 08:22

... 500 mcg of epinephrine (by institutional protocol: 25 mcg/kg every 5 minutes) were given while oxygen inspir- atory fraction was increased to 1. CPB was instituted in 5 minutes in order to improve ... of the intracytosolic calcium rise sustaining vasoconstriction. Finally, prolonged low systemic hypoperfusion with tis- sue hypoxia and lactic acidosis can maintain all the described pat...

Ngày tải lên: 11/08/2014, 11:20

... the lung, releasing numerous mediators that control the remodeling of pulmonary vessels [3,4]. Chymase, a chymo trypsin-like serine protease which is mainly contained in the secretory granules of ... that chy- mostatin administration significantly reduced the smoke- induced increase in chymase activity but had no effect on ACE activity, suggesting that chymostatin was mainly act- ing...

Ngày tải lên: 12/08/2014, 11:21