Báo cáo y học: "Role of epidermal growth factor receptor activation in regulating mucin synthesis" pdf

... caused expression of the MUC5AC mucin (a predominant airway mucin) gene. Interaction of EGFR with its ligands led to EGFR tyrosine kinase phosphorylation, and a selective EGFR tyrosine kinase inhibitor ... virus-induced goblet-cell metaplasia in pathogen-free rats, developing mucin- containing cells did not incorporate [ 3 H]thymidine, suggesting that cell mitosis was not involved...

Ngày tải lên: 12/08/2014, 18:20

... specifically out of the four human FGF8 isoforms, and showed little binding to other members of the FGF family. Neutralizing activity of KM1334 was shown by the blocking of FGF8b binding to its receptors. KM1334 ... using diaminobenzidine (brown) and counter stained with hematoxylin (blue). Very weak stain- ing of FGF8 was observed in a few synovial cells, but not in other tis-...

Ngày tải lên: 09/08/2014, 10:23

... FEBS Introduction Epidermal growth factor receptor (EGFR) is a mem- brane tyrosine kinase that is involved in the regulation of a wide variety of biological processes [1]. Controlled activation of ... quantitatively regulated by upstream signaling dynamics, which concomitantly regulate the dynamics of the original pathway. Kinases and effector proteins in the EGFR-mitoge...

Ngày tải lên: 30/03/2014, 01:20

... malignant meningiomas exhibited very low scores of intensity of EGFR staining, while benign and atypical samples demonstrated a higher intensity of staining. Specifically, 80% (4/5) of malignant samples ... Guarnascelli JJ: Detection of epidermal growth factor and transforming growth factor alpha protein in meningiomas and other tumors of central nervous system in h...

Ngày tải lên: 09/08/2014, 09:20

... In this study we investigated the role of contractile prostaglandins and Rho-kinase in growth factor- induced ASM contraction. Methods: Growth factor- induced contractions of guinea pig open-ring ... 8 Putative mechanism of growth factor- induced airway smooth muscle contraction. Growth factors, like EGF and PDGF, bind to their receptors with intrinsic tyrosine kinase ac...

Ngày tải lên: 12/08/2014, 18:22

... by a 20% (v/v) solution of piperidine in dimethylformamide containing 0.1 M 1-hydroxybenzotriazole. When necessary, a second coupling reaction was made using 1H-benzotriazol-1-yl-oxy-tris(pyr- rolidino)phosphonium ... Because the primary quality control system in charge of rearranging a m isfolded polypeptide chain in the lumen of the endoplasmic reticulum must be relatively unspe...

Ngày tải lên: 23/03/2014, 13:20

... < 0.0001 in both cases). Interestingly, the prevalence of RF-positive patients increased to 37.5% in patients affected by HCV presenting with articular involvement (3 of 8), and 66.7% in patients ... displayed by AKA and later by the tests for detection of anti-filaggrin antibodies [19] were largely overcome after the discovery of citrulline residues as the main anti- genic t...

Ngày tải lên: 09/08/2014, 01:23

... understanding of the complex interplay of growth factors, cytokines, and enzymes in the IVD. To our knowledge, this is the first study that demonstrates the pathophysiologic effects of FGF2 in spine ... increases the expression of cartilage-degrading enzymes by bovine intervertebral disc cellsFibroblast growth factor 2 increases the expression of cartilage-degrading enzyme...

Ngày tải lên: 09/08/2014, 10:23

... and dimethyloxaloylglycineEffects of 2-methoxyestradiol and dimethyloxaloylglycine. Effects on synovial tissue, levels of hypoxia-inducible factor (HIF) 1α and viability of chondrocytes, and ... Induction of osteoarthritis by 2-methoxyestradiol demonstrates the importance of HIF-1 in maintaining the integrity of hypoxic articular cartilage. Stabilization of HIF-1 by dimethy...

Ngày tải lên: 09/08/2014, 13:22

... subsequent myocardial injury, in which apoptosis may play a key role in myocardial IR injury [2]. It is therefore important to find the end ogenous protective mechanism against apop- tosis induced by myocardial ... cardiomyocytes, miRNA’s mimics and AMOs (50 nM) were transferred into the cardiomyocytes with lipofecta- mine 2000 (Invitrogen) 48 h before IR. Flow cytometry analysis of apo...

Ngày tải lên: 10/08/2014, 05:21