Báo cáo y học: "Th2 cytokines and asthma Interleukin-9 as a therapeutic target for asthma" ppsx

... last decade has been the recognition that cytokines play a critical role in orchestrat- ing, perpetuating and amplifying the inflammatory response in asthma. Indeed the increased and abnormal expression ... cytokines in airway cells is one of the major targets of corticosteroid therapy, by far the most effective controller treatment for asthma currently available. Many cytokin...

Ngày tải lên: 12/08/2014, 18:20

... IL-13 signaling and human asthma and atopy. Hum Mol Genet 2000, 9:549–559. 38. Gao PS, Mao XQ, Roberts MH, Arinobu Y, Akaiwa M, Enomoto T, Dake Y, Kawai M, Sasaki S, Hamasaki N, Izubara K, Shirakawa ... Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T, Kawai M, Sasaki S, Dake Y, Hamasaki N, Shirakawa T, Hopkin JM: Ile50Val variant of IL4R αα upregulates IgE synthesis an...

Ngày tải lên: 12/08/2014, 18:20

... eosinophilic infiltration [1]. As a result, the role of chronic pulmonary inflammation in the pathophysiology of asthma has been studied extensively in human and in animal models. In asthma, pulmonary inflammation ... Periph- eral blood and sputum eosinophil levels were measured, and early-phase and late-phase asthmatic responses were assessed by measuring the percentage fall i...

Ngày tải lên: 12/08/2014, 18:20

... http://respiratory-research.com/content/2/2/080 Introduction Asthma is a complex heritable inflammatory disorder of the airways associated with airway obstruction as well as a variety of clinical signs [1,2]. Airway hyperresponsiveness (AHR), a risk factor ... risk factor and a cardinal feature of asthma, is characterized as an exaggerated airway response to an irri- tant s...

Ngày tải lên: 12/08/2014, 18:20

... linkage analysis of rheumatoid arthritis, including covariates. Arthritis Rheum 2004, 50:2757- 2765. 5. Iwamoto T, Ikari K, Inoue E, Toyama Y, Hara M, Yamanaka H, Tomatsu T, Momohara S, Kamatani ... European Caucasian population: a family-based study. Arthritis Res Ther 2007, 9:R63. 2. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA: Definition of two angiogenic pat...

Ngày tải lên: 09/08/2014, 10:21

... predicted for asthmatic and nonasthmatic subjects.R min %predicted for all 34 nonasthmatic (black) and 35 asthmatic (hatched) participants as well as the subgroup of 26 nonasthmatic methacholine ... 0.0001). Figure 1 Typical respiratory system resistance tracings for a nonasthmatic and an asthmatic subject. Typical trace of respiratory system resistance (R rs ) at 8 Hz and...

Ngày tải lên: 12/08/2014, 13:22

... specifically developed for burn injury that use simple clinical parameters. Recently, another equation based on a very large database (68,661 patients) was published, taking into account seven variables, ... illness severity; and a probability model, which is an equation giving the probability of hospital death [2]. Accordingly, illness severity scores applicable for paediatric popu...

Ngày tải lên: 13/08/2014, 11:22

... bi[tris(hydroxymethyl)-meth- ylamino] propane and 10 lL10m MD -Ala- D -Ala, incuba- ted at 37 °C for 30 min, and assayed for D , D -dipeptidase activity using the D -amino acid oxidase assay. Kinetic analysis of VanXY C His 6 –VanXY C (2.25 ... polymerase (Stratagene) was used to amplify vanXY C usingpAT70 4as template with primers A (5¢-GCTA GGTCTCAATGAAC ACATTACAATT-3¢)andB(5¢-TA...

Ngày tải lên: 18/03/2014, 01:20

... was also supported by inhibition studies; CO dehydrogenase activity was specifically blocked by cyanide, and hydrogenase activity was blocked by CO or acetylene. TherateofH 2 formation with CO as ... and 1m M Ti(III)citrate was added to the assay mixture. The gas phase was 100% CO (1 · 10 5 Pa) or as indicated. The reaction was started by the addition of enzyme. The solution was stirre...

Ngày tải lên: 23/03/2014, 21:20

... b-T1 was synthesized as reported by Gao et al. [31] using the construct described in the Materials and methods section and analysed by SDS/ PAGE. [ 35 S]b-T1 has an apparent molecular mass indistin- guishable ... the pUC18 containing the mutated b-T1 was used as a template in a PCR with the oligonucleotides 5¢-CGAGCTCGG TACATATGAGAG-3¢, as forward primer, and 5¢-TCGACTCTAGAGGA...

Ngày tải lên: 23/03/2014, 21:20