Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot

... struc- tures within the joint, including the ability to clearly depict synovitis following the administration of the MRI contrast agent gadolinium-DTPA (Gd-DTPA) [8]. Ultrasound also brings with it excellent ... autonomous of inflammation [5]. At the dawn of the era of biological therapy in RA, this theory led to the concept of a dual-therapeutic strategy, includ...

Ngày tải lên: 09/08/2014, 13:22

... Corticosteroids can regulate the synthesis and function of catecholamines and their receptors, which in turn control vascular tone and organ perfusion [4]. Proinflammatory cytokines released in sepsis alter ... leading to the deleterious effects of catecholamine dysfunction and refractory hypotension [5]. Downregulation of catecholamine receptors occurs with prolonge...

Ngày tải lên: 12/08/2014, 18:21

... University Hospital Maastricht, The Netherlands 2 Trauma Surgeon and Intensivist, University Hospital Maastricht, The Netherlands 3 Fellow in Trauma and Surgical Critical Care, University of Miami ... associated with catheter sepsis). Lutien and colleagues more recently used intravenous and enteral antibiotics (including amphotericin) to achieve decont- amination of the...

Ngày tải lên: 12/08/2014, 19:22

... mild hypokalaemia may offer benefit by promoting cellular calcium entry and increasing the inotropic effect of insulin [21,24]. Recommendations for the use of HIET in CCB poisoning Although there ... variation in insulin dosing in the cases reporting the use of HIET in CCB overdose and in the duration of treatment, rational recommendations could currently co...

Ngày tải lên: 12/08/2014, 23:23

... oligomer formation is essential for Rev activity by assessing the requirements for restora- tion of the activity of the mutant. Results The intracellular localization of Rev and mutants The intracellular ... specific binding of Rev to RRE [3,9- 11]. An other essential domain (aa 75–84) signals active nuclear export of Rev (NES) [8,12-14]. The Rev basic domain binds...

Ngày tải lên: 13/08/2014, 09:21

... DEPOSITORY MAY BE SIMULTANEOUSLY OR SUBSEQUENTLY SUBMITTED TO GENOME BIOLOGY OR ANY OTHER PUBLICATION FOR PEER REVIEW; THE ONLY REQUIREMENT IS AN EXPLICIT CITATION OF, AND LINK TO, THE PREPRINT IN ANY ... preference of the reverse transcriptase enzyme for the Cy3 label and (ii) prolonged exposure to air and light of the dyes increasing the chance of oxidation...

Ngày tải lên: 14/08/2014, 14:21

... the recognition that cytokines play a critical role in orchestrat- ing, perpetuating and amplifying the inflammatory response in asthma. Indeed the increased and abnormal expression of cytokines ... involved in the pathophysi- ology of asthma [1,2]. While some of these cytokines, such as interleukin (IL)-1, tumour necrosis factor-α and IL-6, are involved...

Ngày tải lên: 12/08/2014, 18:20

... differentiation. The induction of T H 2-like Review Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists John ... heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain. Binding of IL-4 resu...

Ngày tải lên: 12/08/2014, 18:20

... antibody with specificity for human and primate interleukin-5 [109,110]. SCH55700 has an affinity for human interleukin-5 of 81 pmol/l and a 50% inhibitory concentration for inhibition of human interleukin-5-mediated ... interleukin-5-induced hyperreactivity was abated by blocking the activity of interleukin-1, and interleukin-1β mRNA and protein levels are increased b...

Ngày tải lên: 12/08/2014, 18:20

... inhibit the activity of IL-4 and IL-5 [11]. However, the crucial roles of these factors in supporting the normal biology of specific cell types Review Th2 cytokines and asthma Interleukin-9 as a therapeutic ... helper type 2 (T H 2) lymphocytes, and the cytokines that they produce, in the pathogenesis of allergic asthma [4,5]. Other forms of asthma...

Ngày tải lên: 12/08/2014, 18:20