Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... struc-
tures within the joint, including the ability to clearly depict
synovitis following the administration of the MRI contrast
agent gadolinium-DTPA (Gd-DTPA) [8]. Ultrasound also
brings with it excellent ... autonomous of inflammation
[5]. At the dawn of the era of biological therapy in RA, this
theory led to the concept of a dual-therapeutic strategy,
includ...
... Corticosteroids can regulate the synthesis
and function of catecholamines and their receptors, which in
turn control vascular tone and organ perfusion [4].
Proinflammatory cytokines released in sepsis alter ... leading to the deleterious effects of
catecholamine dysfunction and refractory hypotension [5].
Downregulation of catecholamine receptors occurs with
prolonge...
... University Hospital Maastricht, The Netherlands
2
Trauma Surgeon and Intensivist, University Hospital Maastricht, The Netherlands
3
Fellow in Trauma and Surgical Critical Care, University of Miami ... associated with catheter sepsis).
Lutien and colleagues more recently used intravenous and
enteral antibiotics (including amphotericin) to achieve decont-
amination of the...
... mild hypokalaemia
may offer benefit by promoting cellular calcium entry and
increasing the inotropic effect of insulin [21,24].
Recommendations for the use of HIET in CCB
poisoning
Although there ... variation in insulin dosing in the cases
reporting the use of HIET in CCB overdose and in the
duration of treatment, rational recommendations could
currently co...
... oligomer formation is essential
for Rev activity by assessing the requirements for restora-
tion of the activity of the mutant.
Results
The intracellular localization of Rev and mutants
The intracellular ... specific binding of Rev to RRE [3,9-
11]. An other essential domain (aa 75–84) signals active
nuclear export of Rev (NES) [8,12-14]. The Rev basic
domain binds...
... DEPOSITORY MAY BE SIMULTANEOUSLY OR SUBSEQUENTLY SUBMITTED TO
GENOME BIOLOGY OR ANY OTHER PUBLICATION FOR PEER REVIEW; THE ONLY REQUIREMENT IS AN EXPLICIT CITATION
OF, AND LINK TO, THE PREPRINT IN ANY ... preference of the reverse transcriptase
enzyme for the Cy3 label and (ii) prolonged exposure to air and light of the dyes increasing
the chance of oxidation...
... the
recognition that cytokines play a critical role in orchestrat-
ing, perpetuating and amplifying the inflammatory
response in asthma. Indeed the increased and abnormal
expression of cytokines ... involved in the pathophysi-
ology of asthma [1,2]. While some of these cytokines,
such as interleukin (IL)-1, tumour necrosis factor-α and
IL-6, are involved...
... differentiation. The induction of T
H
2-like
Review
Th2 cytokines and asthma
Interleukin-4: its role in the pathogenesis of asthma, and targeting
it for asthma treatment with interleukin-4 receptor antagonists
John ... heterodimer of high-affinity IL-4Rα and either the
common γ chain or the IL-13 receptor α chain. Binding of
IL-4 resu...
... antibody with specificity for human and primate
interleukin-5 [109,110].
SCH55700 has an affinity for human interleukin-5 of
81 pmol/l and a 50% inhibitory concentration for inhibition
of human interleukin-5-mediated ... interleukin-5-induced hyperreactivity was
abated by blocking the activity of interleukin-1, and
interleukin-1β mRNA and protein levels are increased b...
... inhibit the activity of IL-4
and IL-5 [11]. However, the crucial roles of these factors
in supporting the normal biology of specific cell types
Review
Th2 cytokines and asthma
Interleukin-9 as a therapeutic ... helper type 2 (T
H
2) lymphocytes, and
the cytokines that they produce, in the pathogenesis of
allergic asthma [4,5]. Other forms of asthma...