Báo cáo y học: "Th2 cytokines and asthma: an introduction Peter J Barnes" pps

... that cytokines play a critical role in orchestrat- ing, perpetuating and amplifying the inflammatory response in asthma. Indeed the increased and abnormal expression of cytokines in airway cells ... the major targets of corticosteroid therapy, by far the most effective controller treatment for asthma currently available. Many cytokines and chemokines are involved in the pathophysi...

Ngày tải lên: 12/08/2014, 18:20

... IL-4Rα. It retains the ability to bind IL-4 with high affinity and high specificity and thereby functions as a decoy receptor which can sequester naturally occurring IL-4 and prevent it from activating ... Rothman P: IL-4/IL-13 signaling beyond JAK/STAT. J Allergy Clin Immunol 2000, 105:1063–1070. 24. Harris M, Chang CC, Berton M, Danial N, Zhang J, Kuehner D, Ye BH, Cattoretti GM, K...

Ngày tải lên: 12/08/2014, 18:20

... largely from a Th2-type lymphocyte response. Eosinophils and neutrophils respond to many common stimulators, such as C5a, phorbol myristate acetate, zymosan, and formyl-methionyl-leucyl-phenylalanine ... 1994, 150:1030–1048. 90. Ying S, Durham SR, Corrigan CJ, Hamid Q, Kay AB: Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2...

Ngày tải lên: 12/08/2014, 18:20

... as an asthma candidate gene by unbiased genetic mapping studies on AHR and linkage homology in both humans and mice. Cell biology in vitro has shown that IL-9 is an important growth factor and stimulator ... by exercise, viruses, aspirin, and occupation. The mechanism underlying these forms of asthma might simi- larly involve T H 2 lymphocytes and cytokines but might be trigge...

Ngày tải lên: 12/08/2014, 18:20

... Strachan DP: Hay fever, hygiene, and household size. BMJ 1989, 299:1259-1260. 2. Romagnani S: Human TH1 and TH2 subsets: regulation of dif- ferentiation and role in protection and immunopathology. ... Allergy Immunol 1992, 98:279-285. 3. Nafstad P, Magnus P, Jaakkola JJ: Early respiratory infections and childhood asthma. Pediatrics 2000, 106:E38. 4. Bodner C, Anderson WJ, Reid TS, G...

Ngày tải lên: 12/08/2014, 18:20

... objective clinical criteria: age greater than 60 years; more than 40% of body-surface area burned; and inhalation injury [5]. With regard to burn injury in children, only demographics and injury ... of inspired oxygen), higher positive Commentary Circulating cytokines and outcome prediction of burned children with concomitant inhalation injury Pavlos M Myrianthefs and George J Bal...

Ngày tải lên: 13/08/2014, 11:22

... this disease, which includes pathophysiology and joint stability including biomechanics. The balance between anabolic morphogens and growth factors and catabolic cytokines is at the crux of the problem of ... as R-Smads and receptor- activated Smads. Phosphorylation of Smads 2 and 3 results in a conformational change and permits interaction with a common Smad (C-Smad) and init...

Ngày tải lên: 09/08/2014, 07:20

... contributions GC and JD drafted the manuscript. FH, LH, SM, CH, FC, JD and NL participated in the design of the study. GC and JD conceived of the study, and participated in its design and coordination. ... Expression of Genes from the Human Active and Inactive X Chromosomes. Am J Hum Genet 1997, 60:1333-1343. 12. Bixel M Gabriele, Petri Björn, Khandoga Alexander G, Khandoga An...

Ngày tải lên: 11/08/2014, 03:20

... contributions GC and JD drafted the manuscript. FH, LH, SM, CH, FC, JD and NL participated in the design of the study. GC and JD conceived of the study, and participated in its design and coordination. ... Expression of Genes from the Human Active and Inactive X Chromosomes. Am J Hum Genet 1997, 60:1333-1343. 12. Bixel M Gabriele, Petri Björn, Khandoga Alexander G, Khandoga An...

Ngày tải lên: 11/08/2014, 06:22

... Mayr VD, Jochberger S, Wenzel V, Ulmer H, Pajk W, Hasibeder WR, Friesenecker B, et al.: Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and ... RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, et al.: Surviv- ing Sepsis Campaign guidelines for management of severe sepsis and s...

Ngày tải lên: 12/08/2014, 23:23