Báo cáo y học: " Matrix metalloproteinases in lung biology" ppsx

... matrilysin expression in other cell types, namely macrophages, fibroblasts, and keratinocytes. The widespread production of matrilysin in conducting airway epithelium may be initially induced ... demonstrate that matrilysin is induced by injury and is prominently expressed by migrating epithe- lial cells. Although we do not yet know what process or factor induces matrilysin in epithelia...

Ngày tải lên: 12/08/2014, 18:20

... important in the pathogenesis and development of inflammatory diseases and are intimately involved in the regulation of the activities of cytokines and cytokine receptors [2]. Pathophysiologically, ... to determine the cellular origin and the relevance of these enzymes in sepsis. Competing interests MBr is an employee of Boehringer Ingelheim GmbH, Germany. The other authors declare that...

Ngày tải lên: 13/08/2014, 19:20

Ngày tải lên: 13/08/2014, 20:21

... signalling in inflammation in the joint [34], we have addressed the potential involvement of Wnt signalling in inflammatory diseases of the lung. Increased levels of pro-inflammatory and inflammatory cytokines ... Furthermore, dominant negative and antisense Wnt5a and anti-Fz-5 antibody block Wnt5-Fz5 signalling leading to decreased cytokine production [33]. Additionally, the inflamma...

Ngày tải lên: 12/08/2014, 16:20

... oxygenase-1 gene promoter may reduce the gene’s inducibility by reactive oxygen species in cigarette smoke, thus resulting in emphysema Cystic fibrosis HLA class II polymorphism in cystic fibrosis. A ... association between a poly- morphism and disease exists can be greatly improved by studying a more narrowly defined intermediate phenotype. In the case of asthma, intermediate pheno...

Ngày tải lên: 12/08/2014, 18:20

... VEGF are found in lungs of transgenic mice overexpressing inter- leukin-13 [15]. Interestingly, accumulation of VEGF in the alveoli appears to make these animals more resistant to injury by hyperoxia ... aimed at restoring lung integrity. For example, diffuse alveolar damage induced by hyperoxia in mice is acutely associated with increased lung levels of FGF7 and FGF2, which promote...

Ngày tải lên: 12/08/2014, 18:20

... baseline, change in weight, change in BMI between surveys and years since quitting. Predictors in each model are shown in the footnote to table 3. Baseline lung function parameters were included in ... also increased by adjusting for years since quitting (p = 0.02). Decline in lung function per pack per day between surveys was greater in men and women with a reduced FEV 1 /F...

Ngày tải lên: 12/08/2014, 18:21

... protein phosphatase nuclear targeting subunit encoded in the MHC class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer’s disease. Mol Brain Res ... disease, a finding in keeping with other complex disorders [24]. In addition, the polygenic inheritance of these variants and their contribution to the overall phenotype diversity an...

Ngày tải lên: 09/08/2014, 20:20

Ngày tải lên: 13/08/2014, 10:20

... declare that they have no competing interests. Published: 24 May 2011 References 1. Wong GK, Poon WS, Boet R, Chan MT, Gin T, Ng SC, Zee B: Intravenous magnesium sulphate for aneurysmal subarachnoid ... placebo-controlled, clinical study. Crit Care Med 2010, 38:1284-1290. 4. Schmid-Elsaesser R, Kunz M, Zausinger S, Prueckner S, Briegel J, Steiger HJ: Intravenous magnesium versus nimodipine...

Ngày tải lên: 14/08/2014, 08:21