Báo cáo y học: "Role of γδ T cells in protecting normal airway function" docx

... effect. γδ T cells can also promote allergic hyper-reactivity, systemically and in the airways Given that certain γδ T cells can produce T H 2-type cytokines, it might be expected that they would ... typically commuting between the two tissues, in particular dendritic cells. However, it is not obvious why in one case γδ T cells are elicited that regulate T H 2-ty...

Ngày tải lên: 12/08/2014, 18:20

... upstream to TATAA boxes from HTLV-1 LTR or from other promoters, the strongest activation by Tax is detected with the TATAA box of the HTLV-1 LTR, indicating that this TATAA box contains a specific Tax ... implementing the full transcriptional activation competence of each of these pathways. Tax also affects the function of various other regulatory proteins by direct protein-protein i...

Ngày tải lên: 13/08/2014, 13:20

... the administration of proinflammatory cytokines, leading to a loss of catalytic activity. This downregulation was at the level of transcription [26]. In the present study, the activity and protein and ... anti- body. Binding of all of the antibodies was detected using an ECL detection system (iNtRON Biotechnology) in accor- dance with the manufacturer’s instructions. The intensit...

Ngày tải lên: 14/02/2014, 18:20

... observed for Y2 38 mutants with the ligands tested (Table 2). These results indicate that the mode of ligand binding is retained in the two mutants, and that the alteration of the spectral effects can ... slightly, suggesting that the overall substrate binding pocket remains intact. In agreement with data from the pH dependence of ligand binding and with the protein crystal structu...

Ngày tải lên: 17/03/2014, 17:20

... the intermediate to that of the ferric derivative, indicates that the new intermediate for H42A is probably a neutral ferric peroxide complex. This suggests that the substrate is bound initially ... Photophysics). RESULTS Mass spectrometry The integrity of the variant proteins was examined to ensure that post-translational modification of the protein had not occurred. Analysis of H42A...

Ngày tải lên: 18/03/2014, 01:20

... declined upon the return of CD8+ cells and became undetectable from 28 to 35 days of infection onwards throughout the rest of the observation period (> 6 months). These results indicate that CD8+ cells ... variety of mechanisms, including cytolytic and non-cytolytic pathways [23-25]. Most NK cells also have the low-affinity Fc-gamma III receptor (CD16), which triggers antibod...

Ngày tải lên: 20/06/2014, 01:20

... therapy. As clinicians attempting to stay current in the evolving science of asthma, we must continue to follow the very exciting literature regarding potential phenotypic and genotypic indicators ... reversibility, and a low FEV to forced vital capacity ratio. 1 An exciting direction with regard to response to asthma therapy is the potential role of a patient’s genetics in determinin...

Ngày tải lên: 08/08/2014, 21:20

... pathway. This is supported by recent findings demonstrating TNFα-independent IL-7-driven inflammatory and bone-destructive activity [6,7]. IL-7 is also able to regulate joint pathology by T cell-driven immune ... respect, the IL-7/IL-7R-stimulated pathology is a target of interest for the treatment of rheumatic diseases such as rheumatoid arthritis, osteoporosis and OA. Competing intere...

Ngày tải lên: 09/08/2014, 10:23

... Expression of STAT4β, lacking the transactivation domain, did not appear to be affected by the STAT4 single nucleotide polymorphisms (SNPs) [13]. STAT1, another member of the STAT family, is activated ... mice with nephritis [20,21], suggesting that STAT1 may play a role in the pathogenesis of SLE. A possible role of SNPs in the STAT1-STAT4 region other than the haplotype tagged b...

Ngày tải lên: 09/08/2014, 13:22

... pathways. Network biomarker as a new type of biomarkers with protein–protein interactions was initiated and investigated with the integration of knowledge on protein annotations, interaction, ... (nGNTInfer), inferring transcriptional regulatory networks from high-throughput data (nTRNInfer), inferring protein-protein interactions by parsimony principle (nInferPPI), inferring protein...

Ngày tải lên: 10/08/2014, 09:22