Báo cáo y học: "Role of γδ T cells in protecting normal airway function" docx
Báo cáo y học: "Role of γδ T cells in protecting normal airway function" docx
... effect.
γδ
T cells can also promote allergic
hyper-reactivity, systemically and in the airways
Given that certain γδ T cells can produce T
H
2-type
cytokines, it might be expected that they would ... typically commuting
between the two tissues, in particular dendritic cells.
However, it is not obvious why in one case γδ T cells are
elicited that regulate T
H
2-ty...
Báo cáo y học: " Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity" pps
... upstream to
TATAA boxes from HTLV-1 LTR or from other promoters,
the strongest activation by Tax is detected with the TATAA
box of the HTLV-1 LTR, indicating that this TATAA box
contains a specific Tax ... implementing the full transcriptional activation competence of
each of these pathways. Tax also affects the function of various other regulatory proteins by direct
protein-protein i...
Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... the
administration of proinflammatory cytokines, leading
to a loss of catalytic activity. This downregulation was
at the level of transcription [26]. In the present study,
the activity and protein and ... anti-
body. Binding of all of the antibodies was detected using an
ECL detection system (iNtRON Biotechnology) in accor-
dance with the manufacturer’s instructions. The intensit...
Báo cáo Y học: Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase A site-directed mutagenesis study docx
... observed for Y2 38 mutants with the ligands tested
(Table 2). These results indicate that the mode of ligand
binding is retained in the two mutants, and that the
alteration of the spectral effects can ... slightly, suggesting that the overall substrate
binding pocket remains intact. In agreement with data from
the pH dependence of ligand binding and with the protein
crystal structu...
Báo cáo Y học: Role of histidine 42 in ascorbate peroxidase Kinetic analysis of the H42A and H42E variants pptx
... the intermediate to that of the ferric derivative,
indicates that the new intermediate for H42A is probably a
neutral ferric peroxide complex. This suggests that the
substrate is bound initially ... Photophysics).
RESULTS
Mass spectrometry
The integrity of the variant proteins was examined to ensure
that post-translational modification of the protein had not
occurred. Analysis of H42A...
Báo cáo hóa học: " Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11" ppt
... declined
upon the return of CD8+ cells and became undetectable
from 28 to 35 days of infection onwards throughout the
rest of the observation period (> 6 months). These results
indicate that CD8+ cells ... variety
of mechanisms, including cytolytic and non-cytolytic
pathways [23-25]. Most NK cells also have the low-affinity
Fc-gamma III receptor (CD16), which triggers antibod...
Báo cáo y học: "Role of Genetic Polymorphisms in Therapeutic Response to Anti-Asthma Therapy" pot
... therapy. As
clinicians attempting to stay current in the evolving science
of asthma, we must continue to follow the very exciting
literature regarding potential phenotypic and genotypic
indicators ... reversibility, and a low FEV to forced vital
capacity ratio.
1
An exciting direction with regard to response
to asthma therapy is the potential role of a patient’s genetics
in determinin...
Báo cáo y học: "Role of interleukin-7 in degenerative and inflammatory joint diseases" potx
... pathway. This is supported by
recent findings demonstrating TNFα-independent IL-7-driven
inflammatory and bone-destructive activity [6,7].
IL-7 is also able to regulate joint pathology by T cell-driven
immune ... respect, the IL-7/IL-7R-stimulated pathology is a
target of interest for the treatment of rheumatic diseases such
as rheumatoid arthritis, osteoporosis and OA.
Competing intere...
Báo cáo y học: "Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region" pot
... Expression of STAT4β,
lacking the transactivation domain, did not appear to be
affected by the STAT4 single nucleotide polymorphisms
(SNPs) [13]. STAT1, another member of the STAT family, is
activated ... mice with nephritis [20,21],
suggesting that STAT1 may play a role in the pathogenesis of
SLE. A possible role of SNPs in the STAT1-STAT4 region
other than the haplotype tagged b...
Báo cáo y học: " Role of clinical bioinformatics in the development network-based Biomarkers" docx
... pathways. Network biomarker as a new
type of biomarkers with protein–protein interactions was initiated and investigated
with the integration of knowledge on protein annotations, interaction, ... (nGNTInfer), inferring transcriptional
regulatory networks from high-throughput data (nTRNInfer), inferring
protein-protein interactions by parsimony principle (nInferPPI), inferring
protein...
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