Báo cáo y học: "Transcriptional regulation of lung development: emergence of specificity" pdf

... transcription of Bmp4 inducible genes. Homozygous functional deletion of Smad4 results in early embryonic lethality before embryonic day 7.5 [26]. Smad5 –/– embryos die between embryonic days 9.5 and 11.5, ... minoo@hsc.usc.edu http://respiratory-research.com/content/1/2/109 commentary review reports primary research commentary review reports primary research Review Transcriptional regul...

Ngày tải lên: 12/08/2014, 18:20

... differen- tiation in erythroid progenitors. Polycytemia vera is a clonal myeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells. Sixty percent of polycytemia ... survival of early hematopoietic cells, at the expense of differenti- ation. The proto-oncogene c-Myb c-Myb is abundantly expressed in immature hematopoietic cells of erythr...

Ngày tải lên: 08/03/2014, 22:20

... Brinck- erhoff CE: A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflamma- tory cytokines. Arthritis Rheum 2001, 44:1096-1104. 64. Suh N, Wang Y, ... in inflammatory arthritis. J Clin Invest 2000, 105:1799-1806. Arthritis Research Vol 4 No 3 Vincenti and Brinckerhoff to the transcription of an array of inflammatory genes, their dir...

Ngày tải lên: 09/08/2014, 03:24

... Loss of expression of KLF17 by transcriptional suppression or inactivation by post-translational modification (possibly by phosphorylation or dephosphorylation) leads to transcription of ID1 ... amino-terminal region of KLF17. Given that the activity of some Sp1/KLF family members is known to be regulated by PKC isoforms [8,24-26], it is plausible that the ability of KLF17 to...

Ngày tải lên: 09/08/2014, 20:20

... is one of the key features of systemic scle- rosis (SSc) (scleroderma), a prototypic fibrotic condition * Correspondence: carlo.chizzolini@unige.ch 1 Immunology and Allergy, Department of Internal ... 12:R73 http://arthritis-research.com/content/12/2/R73 Page 12 of 14 of SSc dermal fibroblasts [39]. It is therefore likely that the effect of bortezomib on type I collagen synthesis...

Ngày tải lên: 12/08/2014, 12:20

... of gene regulation. Methods 2009, 47:1-5. 22. Vassylyev DG, Sekine S, Laptenko O, Lee J, Vassylyeva MN, Borukhov S, Yokoyama S: Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 ... wt T4 DNA, each cytosine in this sequence is modified by the presence of a hydroxy- methylated, glucosylated moiety at cytosine position 5. This modification places a large, bulky group with...

Ngày tải lên: 12/08/2014, 02:20

... of Immunology and Biotechnology, University of Pécs, Pécs, Hungary, 2 Institute for Biomedical Research, University of Birmingham, Birmingham, UK and 3 Department of Medicine, University of ... have been reported in different types of lung cancers [76,77], mutations of APC [78] and β-catenin [79,80] are rare in lung cancers. However, proof of dysregulation of specific...

Ngày tải lên: 12/08/2014, 16:20

... pulmonary hyper- tension. Effect of prostacyclin therapy. Am J Respir Crit Care Med 2000, 162:1493-1499. 24. Yi ES, Williams ST, Lee H, Malicki DM, Chin EM, Yin S, Tapley J, Ulich TR: Keratinocyte ... ablation of granu- locyte macrophage-colony stimulating factor in mice results in lungs with features of human alveolar proteinosis [11]; pulmonary fibrosis is observed in neonatal lungs...

Ngày tải lên: 12/08/2014, 18:20

... Respiratory Research 2010, 11:32 http://respiratory-research.com/content/11/1/32 Page 5 of 13 severe disease severity, as defined by the activity and physical examination criteria of the scoring system ... Hospital of the Ludwig-Maximilians-University, Munich, Germany. 2 Children’s Hospital, University of Berne, Switzerland. 3 Department of Dermatology and Allergy, Ludwig-Maximilian...

Ngày tải lên: 12/08/2014, 11:21

... as well. When we analyzed the histories of regulatory interactions, we found that the evolution of regulation by duplication was rare, and surprisingly, many of the regulatory interactions that ... γ-Proteobacteria. Evolutionary histories of regulatory interactions Little of gene regulation arises by duplication As discussed above, most of the TFs that we analyzed appear to ha...

Ngày tải lên: 14/08/2014, 08:20