Báo cáo y học: " Nitric oxide: a pro-inflammatory mediator in lung disease?" potx

... primarily regulated transcrip- tionally and is commonly induced by bacterial products and pro-inflammatory cytokines. As such, inflammatory diseases of the respiratory tract, such as asthma, acute respiratory ... Kamisaki Y, Wada K, Bian K, Balabanli B, Davis K, Martin E, Behbod F, Lee YC, Murad F: An activity in rat tissues that modifies nitrotyrosine- containing proteins. Proc Natl Aca...

Ngày tải lên: 12/08/2014, 18:20

... 3'-TTCCAACA- GACGTACCT-5' (iNOS); 5'-AGGACAGACGGCAAG- CACGA-3', 3'-GGTGGCGGAGTGATGGTCAA-5' (nNOS); 5'-CAGTGTCCAACATGCTGCTGGAAATTG-3', 3'-CCG- TAGTGGTCCTTCTTCTGGAAAT-5' ... inflammation may be contributing factors to the variability of NO in the exhaled breath. For example, elevated Th2-type cytokine (IL-13) in large airways may lead to a...

Ngày tải lên: 12/08/2014, 14:20

... (Amersham Pharmacia Biotech, Little Chalfont, Buckinghamshire, UK) using X- ray film. Statistical analysis All data are presented as means ± SE. Data obtained from all the experiments was analyzed ... smoke and generated from asbestos fibers acti- vate mitogen-activated protein kinase (MAPK) signalling cascades in lung epithelial cells [13]. Airway MUC5AC mucin is transcriptionally upregu...

Ngày tải lên: 12/08/2014, 15:20

... tissue events. In particular, cytokine mediated pathology may be distinct in cartilage and bone as opposed to synovial tissue or draining lymph node. For many given cytokines, establishing tissue ... (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony- stimulating factor and not via interferon-gamma to inhibit osteoclast formation. J Ex...

Ngày tải lên: 09/08/2014, 06:22

... pro- teases can act in concert both extracellularly and intracellularly [18,21]. Extracellularly, collagens can be degraded by collagenase, gelatinases A and B, stromelysin, and the cathepsins. ... definitive answers in the future. Emphysema is characterized by the proteolytic degrada- tion of lung extracellular matrix, especially lung elastin. The elastinolytic cysteine proteases c...

Ngày tải lên: 12/08/2014, 18:20

... study clearly demonstrated the in- creased production of nitric oxide by increased activity of nitric oxide synthase. The increased activities of argininosuccinate synthetase and argininosuccinate ... after anoxia. The Figure 2 shows activities of AS, AL and arginase in the study. AS and AL activities increased in all the three brain regions significantly in anoxia suggesting...

Ngày tải lên: 26/10/2012, 09:07

... December 1985 and October 1991 at the German Heart Institute, Berlin, Germany. All patients had congenital cardiac defects typically associated with pulmonary hypertension and had a lung biopsy taken during ... pulmonary hypertension, and may be a compensatory mechanism limiting the rise in pulmonary artery pressure. Introduction Nitric oxide (NO) plays a central role in the mai...

Ngày tải lên: 12/08/2014, 14:20

... Germany 2 Aneszteziológiai és Intenzív Terápiás Klinika, Semmelweis Egyetem, H-1125 Kietvolgyi, Budapest, Hungary 3 1. Interni klinika, Karlova univerzita Praha, Lekarska fakulta a Fakultni nemocnice, Allej Svobody ... increased accumulation of pulmonary leukocytes [6]. Furthermore, iNOS –/– caused enhanced pulmonary inflammation after instillation of lipopolysaccharide into the lung [7],...

Ngày tải lên: 13/08/2014, 08:21

... an active complex that mediates an intracellular event (for example, activation of adenylate cyclase). Cocchi et al. Annals of General Psychiatry 2010, 9:25 http://www.annals-general-psychiatry.com/content/9/1/25 Page ... platelet adenylate cyclase. Biol Psychiatry 1988, 23:543-559. 28. Garcia-Sevilla JA, Padro D, Giralt MT, Guimon J, Areso P: Alpha 2- adrenoceptor-mediated inhibition of pl...

Ngày tải lên: 08/08/2014, 23:21

... compartmentalization in lymphoid tissues under non-inflammatory conditions [2]. Most chemokines play a role in inflammatory conditions by inducing integrin activation, chemotaxis, and angiogenesis. Apart ... modulating migration directly, chemokines can stimulate cells to release (pro)inflammatory mediators such as cytokines and matrix metalloproteinases [3]. Increased expression of inf...

Ngày tải lên: 09/08/2014, 01:23