Báo cáo y học: " Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione" pdf

... effects on epithelial cell proliferation by increasing proliferation at low, and decreasing proliferation at high concentra-tions both in subconfluent layers of epithelial cells and during wound ... extract of cigarette smoke to gain insight intothe effect of cigarette smoke on epithelial cells. Much of CSC-induced phosphorylation of p38 and JNKFigure 7CSC-induced phosphorylation of p38 and ... study we have focussed on the effects of cigarette smoke on proliferation and wound closure in cultures of bronchial epithelial cells. These in vitro results may addnew elements to our insight into...

Báo cáo y học: "A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: A retrospective study" potx

... specificity of 88.24%, but alow sensitivity of 31.25%, at cut-off line 30 and this ten-dency did not change at cut-off line 35. On the contrary,both the sensitivity and specificity calculated by the ... ALT-LDH index with a cut-off of 3.0 increased from the firstday to the third day: 75% and 100%, respectively.Discussion In this study we demonstrated the contrasting transitions of the ALT-LDH index ... normalizedratio (PT-INR) over 1.5 were enrolled into this study,amounting to 33 patients (Table 1). In order to focus on the early phase of ALF, those in whom the onset of any of clinical symptoms, such...

Báo cáo Y học: The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells potx

... Sertoli cells Connie C. S. Wong and Will M. LeeDepartment of Zoology, The University of Hong Kong, ChinaMer belongs to the Tyro 3 family of receptor tyrosinekinases (RTKs). Together with Axl and ... Sp1,Sp3 and E2F binding sequences on the Mer promoter play asigniﬁcant role in regulating the transcription of Mer.The effects of Sp1 and Sp3 over-expression on the transcrip-tional activity of ... receptorsthat contain intrinsic protein tyrosine kinase activity in theircytoplasmic regions. They are responsible for transmittingsignals from the extracellular environment into the cellcytoplasm...

Báo cáo y học: "Light chain (AL) amyloidosis: update on diagnosis and management" pps

... plasma cells in the bone marrow, light chain amyloid may localized to a single site, most often the skin, larynx or urinary tract[13]. Isolated pulmonary nodules and colonic polyps may represent ... IgG injection, visceral amyloid deposits were densely infiltrated by inflammatory cells and by 7 days almost all amyloid in the liver and spleen was destroyed. Amyloid clearance was largely complete ... distinctly different from therapy for hereditary variants or secondary amyloidosis, should only be considered once the precursor protein is identified with certainty. In the absence of clonal...

Báo cáo y học: "Goal-directed intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk surgical patients: a randomized, controlled trial" pot

... analysisTheprimaryoutcomevariablewasthedurationofhos-pital stay. Secondary outcome variables were the inci-dence of p erioperative complications, the duration of the ICU stay, the amount and type of fluids used intrao-peratively, and ... goals varywidely in the literature. Lithium indicator dilution wasuse d by Pearse and colleagues [1] to determine CO and DO2I in patients undergoing major abdominal surgery. In this study, patients ... perfu-sion in an animal model and found a significantlyincreased microcirculatory blood flow and tissue oxygentension with goal-directed administ ration of colloids.The ongoing discussion about...

Báo cáo y học: " Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig" ppsx

... median and interquartile range* p < 0.05‡ p ≤ 0.01Morphometry of pulmonary arteryFigure 2Morphometry of pulmonary artery. Hematoxylin-eosin stained sections of main pulmonary artery (upper ... AbstractBackground: Cigarette smoking may contribute to pulmonary hypertension in chronicobstructive pulmonary disease by altering the structure and function of pulmonary vessels at earlydisease stages. ... evaluated in rings of pulmonary artery and aorta as the relaxation inducedby ADP. The proliferation of smooth muscle cells and their phenotype in small pulmonary vesselswere evaluated by immunohistochemical...

Báo cáo y học: "Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cells" pot

... prostaglandins and a variety of cytokines [7]. In the lungs and skin of smokers mast cells increase in absolute numbers and smoking may be associated with activation of mast cells [8,9]. They may contribute ... mucolyticactivity, L-cysteine donation, and these could also play a role in modulating the effects of cigarette smoke [44].Abbreviationsairway epithelial cells, AEC; cigarette smoke solution,CSS; ... areduction in nitrite concentration and iNOS expression in a murine lung epithelial cell line in vitro[37]. In contrast,Comhair et al showed no change in iNOS expression in airway cells from healthy...

Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"

... multiple ingredients. The current study assessed the thermogenic effects of p-synephrine alone and in conjunction with the flavonoids naringin and hesperidin in a double-blinded, randomized, ... reported in previous studies involving p-synephrine [17, 18]. The increase in RMR between Group 4, the combination of p-synephrine with 600 mg naringin and 100 mg hesperidin, and the placebo control ... no effects on heart rate or blood pressure were observed in response to p-synephrine or p-synephrine in combination with naringin and hes-peridin (Table 2). p-Synephrine differs from ephedrine...

Báo cáo y học: "Effects of Flurbiprofen on CRP, TNF-α, IL-6, and Postoperative Pain of Thoracotomy"

... Department of Thoracic Surgery, Konya Education and Research Hospital, Konya, Turkey; 2. Microbiology Laboratory, Konya Education and Research Hospital, Konya, Turkey  Corresponding author: ... proteins. Proinflammatory cy-tokines induce not only a local inflammation at the site of injury, but also systemic responses such as tachycardia, tachypnea, leukocytosis, and pyrexia (1). Increased ... Thoracotomy pain, Inflammatory response, Flurbiprofen Introduction Surgical trauma induces an inflammatory state characterized by the release of both proinflammatory and antiinflammatory proteins....

Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"

... (VSMC) proliferation is one of the important features of atherosclerosis. The gap junction (GJ) and connexin (Cx) between cells play crucial roles in the VSMC disintegration and proliferation ... neointima proliferation and down-regulate the elevated protein expression of Cx43, suggesting the rennin-angiotensin system (RAS) plays an important role in the remodeling of gap junction between ... ventricular myocytes under pa-thological conditions. Key words: vascular proliferation; gap junction; connexin; balloon angioplasty; statin Introduction Atherosclerosis is a slow and complicated...

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