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Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during " doc

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Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx

... of the immunoglobulinsuperfamily which is activated by a variety of proinflammatoryligands, including HMGB1, advanced glycated endproducts,members of S100 proteins, and amyloid beta-peptide ... alarmins is therefore their translocation from the inside to the outside of the cell [1]. During the past decade, studies in both patients and animalmodels have established the alarmin activity of ... differences in the behavior of HMGB1 observedmay reflect the experimental systems used, including the celllines and inducers of apoptosis and necrosis.While these issues require further study, understanding...
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Báo cáo y học: " Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literatur" pps

... contributionsHP and NM collected the data and drafted the manuscript. HP and JLcontributed to the treatment of the patient. LY and OL participated in critical revision of the report and helped draft the ... 0.7600.20.40.60.811.21.41.61.8CREATININE mg/dlDAY OF ADMISSIONSERUM CREATININE TREND DURING COURSE OF ADMISSIONCreatinine mg/dlUpper Limit of NormalLower Limit of NormalFigure 3 Graph showing trend of serum creatinine during ... generalized w asting and non-tender, rubbery axillary and inguinal lymphadenopathy.There was no evidence of cyanosis, digital clubbing, pit-ting edema, skin rash or joint deformities. Her abdomenwas...
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Báo cáo Y học: Herbaspirillum seropedicae signal transduction protein PII is structurally similar to the enteric GlnK potx

Báo cáo Y học: Herbaspirillum seropedicae signal transduction protein PII is structurally similar to the enteric GlnK potx

... Elevencycles of model building and refinement resulted in an R-factor of 23.1%. and Rfree of 29.8% In the last cycle, 125molecules of water were added and the R-factors dropped to20.3 and 27.3%, ... stereochemical quality of the final model of the HsPII protein was verified byPROCHECK[19]. The coordinates weredeposited in the Protein Data Bank as the code 1HWU.RESULTS AND DISCUSSIONOverall ... of bothnative and N-terminal hexa histidine-tagged HsPII yieldedpromising microcrystals. Conditions were optimized byaddition of a number of additives [10]. HsPII protein (14 mgÆmL)1)andHis6–PII...
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Báo cáo y học: "A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis" ppt

... chondrocytes treated with azacytidine, reduced Smad2 and Smad3 expression and signaling and increased Smad1/5 expression correlated with elevated synthesis of type X collagen and alkaline ... the degradation of Smad1/5/8 while Smurf2 stimulates mainly the degradation of Smad2/3 [103]. Mitogen-activated protein kinases (MAPKs) modulate the stability and degradation of the Smads by ... and phopshatidylinositol-3-kinase pathways are involved in TGFβ signaling (reviewed in [35]). Activation of TGFβ activated kinase 1 occurs independent of ALK5 kinase activity and results in...
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Báo cáo y học: "A role for MCP-1/CCR2 in interstitial lung disease in children" pps

... parameters and the ILD disease severity score and by the finding that the deceased children with the mostsevere course of disease exhibited the highest BALF levels of these markers. The possibility that ... the patientsChildren attending the Department of Pulmonology and Allergology of the University Children's Hospital of Munich during 1999–2004 were considered for inclusion in this study. ... the study design and reviewed the manuscript. SKE designed the study, supervised the experimental analyses and wrote the manuscript. All authors read and approved the finalmanuscript.AcknowledgementsThis...
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Báo cáo y học: " Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis" pot

... circulatory failure unexplained by other causes(>2 points in SOFA score for the cardiovascular system). The patients included in this study did not receivelow-dose hydrocortisone therapy as routine ... **P < 0.01.Table 3 Correlations of sFas and IL-6 levels with the organ dysfunction scoring systemsaSOFA MODS Protein Day 1 Day 5 Day 9 Day 1 Day 5 Day 9sFasNonsepsis 0.38NS0.25NS0.42NS0.35NS0.25NS0.29NSSepsis ... Boxplotsrepresent the median (heavy line in boxes) and the 25th and 75th percentiles (lower and upper lines of the box, respectively). Whiskers indicate the minimum and maximum values, respectively. *P <...
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Báo cáo Y học: Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways docx

Báo cáo Y học: Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways docx

... human double-stranded RNA acti-vated protein kinase induced by interferon. Cell 62, 379–390.2. Hovanessian, A.G. (1989) The double stranded RNA-activated protein kinase induced by interferon: dsRNA-PK. ... (2000)Activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase by double-stranded RNA and en-cephalomyocarditis virus: involvement of RNase L, protein kinaseR., and alternative ... of ASK1carrying a point mutation of K to M at position 709 (ASK-KM) were kindly provided by H. Ichijo (Laboratory of CellSignaling, Tokyo Medical and Dental University). The plasmid encoding...
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Báo cáo y học: "Endotoxin-activated microglia injure brain derived endothelial cells via NF-B, JAK-STAT and JNK stress kinase pathways" docx

... aminoguanidine) and ROSinhibitors (apocynin and allopurinol) markedly reducedendothelial disruption in this in vitro model. Since we alsofound that SIN-1 was highly effective in inducing dosedependent ... helpconceptualize the study, participated in its design and coordination,interpreted the data and critically shaped the manuscript draft. All authorsread and approved the final version of the manuscript.Competing ... stimulation led to death of mostly bEND.3cells. Pretreatment with NOS (L-NMMA and aminogua-nidine) and ROS inhibitors (apocynin and allopurinol)markedly prevented cell death and b.END3 monolayerdisruption...
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Báo cáo y học: " Metabolic responses to high protein diet in Korean elite bodybuilders with high-intensity resistance exercise" docx

... the bodybuilders showed intakes of protein of 34% of total calories [10].If dietary protein and overall calorie intake are inade-quate, body proteins will be broken down to meet the body’ s ... infor-mation of metabolic responses to high protein intake in bodybuilders. Further studies would be required todetermine the effects of the intensity of exercise and the level of mineral intakes, ... dietary intake, three-day food recordswere used to assess the amount of ingested foods and number of daily meals (breakfast, lunch, dinner, and snacks). Athletes also recorded all of the supplementsthey...
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Báo cáo y học: "High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts" doc

... been reported by us and others, while the synergistic effects of HMGB1 and IL-1aare described for the first time in this study.So, in addition to the direct cytokine-inducing effects of HMGB1 ... signalling forinduction of cytokine productionHMGB1 has been demonstrated to interact with TLR4 and thereby to induce cytokine production [13,46].Although the HMGB1 used in this study did not ... xeswere mediated via the IL-1RI and that the stimulatoryactivity of the H MGB1-LPS complex was mediated viaTLR4. Interestingly, blockade of TLR4 did not suppress the stimulation induced by HMGB1-IL-1b...
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