Báo cáo y học: "Integrated safety in tocilizumab clinical trials" ppsx

... Toxicity Criteria; CV, cardiovascular; DMARD, disease-modifying antirheumatic drug; GI, gastrointestinal; HDL, high-density lipoprotein; IL-6, interleukin-6; LDL, low- density lipoprotein; LITHE, tociLIzumab ... laboratory abnormalities (primarily increased aminotransferases). Of the 257 AEs (in 217 patients) managed by dose reduction, 247 (96%) resulted in continuation of tocilizum...

Ngày tải lên: 12/08/2014, 18:20

... 2005. 9. German Society for Psychiatry, Psychotherapy, and Neurology: Therapeutic Measures in Aggressive Behavior in Psychiatry and Psychotherapy Darmstadt, Germany: Steinkopff; 2009, [in German]. 10. ... regarding chemical restraint in routine clinical psychiatric practice. There may be wide variations between different settings and countries. Methods: A retrospective study on chemi...

Ngày tải lên: 09/08/2014, 01:21

... of special interest since, besides their plasticity, they show immunosuppressive and anti- inflammatory characteristics in vitro and in both preclinical and clinical studies. Thus, they fulfill ... purpose, 3D in vitro high-density chondrocyte pellet and alginate cultures help to preserve/regain the chondrocyte phenotype following monolayer expansion by offering cell-cell and cell-mat...

Ngày tải lên: 09/08/2014, 01:22

... scans showed symmetric hyperintensity in the pons, confirming the diagnosis of osmotic demyelination syndrome [17]. Severe hyponatremia may be caused by a variety of mech- anisms, including hypovolemia, ... cytokines by brain microglia or astrocytes in response to intense inflammation in meningoencephalitis. Moreover, hypo- thermia has been reported to inhibit the production of IL- 6, w...

Ngày tải lên: 11/08/2014, 21:22

... imple- mented in recent years in critically ill populations, including include standard ventilatory weaning methods [32], protocol- ized ventilatory strategies for patients with acute lung injury [33,34], ... Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gava- ghan DJ, McQuay HJ: Assessing the quality of reports of rand- omized clinical trials: is blinding necessary? Control Clin Trial...

Ngày tải lên: 13/08/2014, 03:21

... formulation yet. Methods: Prospective, multicentre study in which efficacy, safety and pharmacokinetics of a regimen of once-daily SQVr 1500/100 mg plus 2 NRTIs wer e evaluated under routine clinical ... Schwartz R, Jayaweera DT, Burnside AF, Walmsley S, Saag MS: Efficacy, safety and pharmacokinetics of once-daily saquinavir soft-gelatin capsule/ritonavir in antiretroviral-naive, HI...

Ngày tải lên: 10/08/2014, 05:21

... Disorders. Washington DC: American Psychiatric Association, 4 2000, text revision. 11. Guy W: Clinical Global Impressions. In ECDEU Assessment Manual for Psychopharmacology. Edited by: Guy W. Washington ... changes in the MADRS scores from baseline and changes in Clinical Global Impressions - Improvement of Illness (CGI-I) scale [11]. Outcome measures: Safety and tolerability Saf...

Ngày tải lên: 11/08/2014, 16:23

... excretion Protein binding ↓ Increased drug availability Increased risk of side effects Gastro-intestinal resorption ↑ Increased drug availability both in peripheral organs and the brain CYP450, P-450 cytochrome ↑, ... (revealing a very high enzyme activity which is genet- ically caused by gene duplication, so far only found for CYP2D6 and CYP2A6; [29]. The phenotypes reflecting the actual e...

Ngày tải lên: 13/08/2014, 18:21

... planning, teaching and training responsibilities offers possibilities for planning, teaching and training disaster medicine by giving immediate feed- back based on real incidents. Background Introduction To ... be included in the risk assessment regarding possible major incidents in this region. The purpose of this study was to find whether this institution has achieved its primary tasks...

Ngày tải lên: 25/10/2012, 09:56

... family history, ethnicity, increasing age, central obesity, physical inactivity, low HDL/high triglycerides, fasting glucose of 110 mg/dL or greater, gestational diabe- tes, hypertension, and polycystic ... Angiotensin Converting Enzyme CYP = Cytochrome P450 + Not all agents are appropriate for monotherapy. Inclusion in this table does not necessarily imply efficacy. * Currently FDA approv...

Ngày tải lên: 25/10/2012, 10:51