Báo cáo y học: "Desperately looking for the right target in osteoarthritis: the anti-IL-1 strategy" pptx

... intra articular injections to increase the local concen tra- tion of the drug into the joint, especially during fl are-up of the disease. In doing so, we can also hope to diminish the risk of serious ... of the knee. Ann Rheum Dis 2000, 59:71-74. doi:10.1186/ar3436 Cite this article as: Chevalier X, et al.: Desperately looking for the right target in osteoarthritis...

Ngày tải lên: 12/08/2014, 17:22

... aspects clearly play a role in the persistence of zootherapeutic practices. Yet, the inclination of the younger generation towards welcoming and accepting modern medicine, while neglecting their own ... tuberculosis, for instance, could involve body parts of any one of these animals: porcupine, deer, fox, or mole. U sing a var iety of remedies for one and the same ailment and th...

Ngày tải lên: 10/08/2014, 09:21

... times daily for 3 days, and enrofloxa- cin once daily for 5 days, in doses previously outlined. The rabbits were inspected routinely throughout the day for abnormal activity, evidence of pain, and ... sections of the specimens. Otherwise, all stained myelinated fibers were included in the database for analysis. In order to prevent grading bias, the observe r was blinde...

Ngày tải lên: 10/08/2014, 10:20

... asthma. Conclusion Although the morbidity and mortality from asthma are increasing in the USA and around the world, the minority of adults with asthma will experience hospitalization or death from asthma. Targeted interventions ... Understanding the factors underlying hospitalization for asthma could help elucidate the recent rise in asthma morbidity. Abstract Background: T...

Ngày tải lên: 12/08/2014, 18:20

... cytolysis of infected cells. We propose that inhibiting HEXA would increase the lev- els of circulating GM2 in vivo, thereby creating a more pro- nounced level of infected cell cytolysis. Using ... determined by the intersection of the x and y values for that probe set. 2-fold, 3-fold, and 10-fold change lines are defined by the following equations: y = 2x and y = 1/2x, y...

Ngày tải lên: 13/08/2014, 09:21

... metal binding. Specificity of Zn(II) binding by the purified Zn(II)-binding proteins The specificity of Zn(II) binding was also examined for the purified Zn(II)-binding proteins. The binding of radioactive Zn(II) ... N-terminal sequencing. In addition to five known zinc-binding proteins, nine zinc- binding proteins were newly identified including: acetate kinase (AckA), DnaK, serine hyd...

Ngày tải lên: 22/02/2014, 04:20

... agents for which efficacy has been already established in murine models of lupus may offer interesting therapeutic avenues in the future. The ubiquitin–proteasome pathway is involved in intracellular ... describing the successful use of new therapeutic agents in murine models support their further evaluation as therapies for SLE. In lupus, therefore, the therapeutic pote...

Ngày tải lên: 09/08/2014, 14:21

... number not for citation purposes) cacy and response to rituximab therapy, consistent with the notion that targeting cells with the memory phenotype is a key determinant for its efficacy. Whether persistence ... [26]. Our data further support these findings since we observed a significant decrease in CD19 + CD27 + memory B cells not only in the PB but also in the BM of RA pa...

Ngày tải lên: 09/08/2014, 14:22

... capecitabine (Xeloda) was reversed by changing the schedule of medication to biweekly 7/7 (7 days ingesting drug alternating with 7 days off drug) from the 14/7 (14 days ingesting drug alternating ... previously pre- dicted by laboratory experiments, thus lending support to the validity of chemotherapy schedule modelling based on Gompertzian tumor cell kinetics and the Norton- Simon...

Ngày tải lên: 11/08/2014, 12:20

... synthesis, but type II collagen synthesis is increased during OA as discussed above.  is discrepancy points to alternative players that are involved in OA. IL-1 might play a role in the induction ... Functional articular cartilage is maintained by the cartilage cells, chondrocytes. Changes in chondrocytes, leading to the inability of these cells to maintain the homeostasis...

Ngày tải lên: 12/08/2014, 11:22