Báo cáo y học: " Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis" ppsx

... primer for TXNDC5, 5’ -GCCTCCACTGTGCTCACTGA-3’;forwardprimerforhumanb-actin, 5’-TGGCACCCAGCACAATGAA-3’;andreverseprimer for human b-actin, 5’-CTAAGTCATAGTCCGCC-TAGAAGCA-3’. Primer efficiency was ... using a plate reader (Synergy HT, Bio-Tek,Winooski, VT, USA). We repeated the ELISA three timesand obtained the similar results.Sandwich ELISA has low inter-assay and intra-assayvariability ... ofgenotyping.Statistical analysisGenotyping SNPs were analyzed for association by com-parison of the MAF in cases and controls. Associations ofSNPs w ith RA and AS were eva luated using odds ratiosTable...

Báo cáo y học: "Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production" ppt

... gel zymography assay, which partly prove thatCD147 upregulation on macrophages may increase MMPproduction through both autocrine and paracrine stimulationand that macrophages may act as an amplifier ... antibody and AP9Based on the reports that CD147 is a high affinity receptor for CyPA and responsible for a cyclophilin signaling cascade thatculminates in extracellular signal-regulated kinase ... pathoge-netic cascade in RA via an increase in MMP production byinteracting macrophages and fibroblasts.Bukrinsky and colleagues have reported that CD147 is a highaffinity receptor for CyPA...

Báo cáo y học: "New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples" docx

... HLA shared-epitope genotypes for rheumatoid arthritis. Am J Hum Genet 1996, 58:371-383.23. Kochi Y, Yamada R, Kobayashi K, Takahashi A, Suzuki A, Sekine A, Mabuchi A, Akiyama F, Tsunoda T, Nakamura ... USA) and the help of technical and clinical collaborators from the rheumatoid arthritis international working group, for clinical data management and laboratory typings. The authors are indebted ... 31:361-370.19. Linos A, Kaklamani VG, Kaklamani E, Koumantaki Y, Giziaki E,Papazoglou S, Mantzoros CS: Dietary factors in relation to rheu-matoid arthritis: a role for olive oil and cooked vegetables?Am...

Báo cáo y học: "The value of sensitive imaging modalities in rheumatoid arthritis pdf

... conventional grey-scale (B-mode) ultrasonography (US) in the evaluation ofRA synovial inflammation and joint damage indicate thatclinical joint examination and CR are comparatively insen-sitive ... damage tojoints in rheumatoid arthritis (RA) is essential in bothroutine clinical management and clinical trials. But doesconventional radiography (CR) remain the gold-standardmethodology ... structural damage to joints. Preser-vation of joint integrity is closely associated with mainte-nance of functional capability. However, many patientswith early RA are excluded from clinical studies...

Báo cáo y học: "Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures" doc

... colleagues [15] noted a higheraverage urinary nitrate/creatinine ratio in patients with RA than in controls after only an overnight fast. Our analyses showedthat urinary NOx and NOx/creatinine ... in any medium, provided the original work is properly cited.AbstractNitric oxide (NO) may play important roles in rheumatoid arthritis(RA). RA is an inflammatory disease involving joints and ... reagent. RA activity was assessed usingstandard clinical and laboratory measures. While consuming a restricted diet for 3 days to eliminate the effects of oral intake ofNOx, 24 hour urinary NOx...

Báo cáo y học: "Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study" docx

... membrane analysis of synovial fibroblast supernatantsProteomic membrane analysis of synovial fibroblast supernatants. (a) Comprehensive protein membrane array map. The human protein array simulta-neously ... Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S:Membrane-associated prostaglandin E synthase-1 is upregu-lated by proinflammatory cytokines in chondrocytes frompatients with osteoarthritis. ... regulation as determined by GCOS analysis. Genes were functionally categorized into inflammatory/catabolic mediators and genes involved in the degradation and formation of extracellular matrix...

Báo cáo y học: "Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis" ppt

... Takizawa Y, Suzuki A, Sawada T, Ohsaka M, Inoue T, Yamada R,Yamamoto K: Citrullinated fibrinogen detected as a soluble cit-rullinated autoantigen in rheumatoid arthritis synovial fluids.Ann Rheum ... (Dako,Carpinteria, CA, USA). For fibrinogen and IgG staining, pre-treatment of proteinase K (Dako, Carpinteria, CA, USA) wasused before the primary antibody incubation. Slides positive for ... ICs, a PsApatient and a healthy control (Figure 2a) . Forty-five fractionswere generated of each patient's plasma and each fractionwas assayed for ICs, fibrinogen-containing ICs, total immu-noglobulin,...

Báo cáo y học: "Trends towards an improved disease state in rheumatoid arthritis over time: influence of new therapies and changes in management approach: analysis of the EMECAR cohort" ppt

... Gerards AH, Landewe RB, Prins AP, Bruyn GA, Goei The HS,Laan RF, Dijkmans BA: Cyclosporin A monotherapy versuscyclosporin A and methotrexate combination therapy in patients with early rheumatoid ... hemoglobin, alkaline phosphatase, bodymass index and the DAS28-3, the HAQ score and the Larsenscore at baseline.Bivariate analysis was performed with all factors and covari-ates, and then backward ... prescriptionat each visit (gold salts, antimalarial, methotrexate (MTX), LEF,sulfasalazine cyclosporine A, aTNF and others), the followingcovariates were also analyzed: age at disease onset, age atbaseline,...

Báo cáo y học: "Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritsi" potx

... second-ary staining of biotinylated NGF was added and cells wereincubated for 30 minutes at 4°C. After three washes (300 g/three minutes) with PBS/BSA, cells were ready for FACSanalysis.Phenotypic ... NGF is also involved in humoral immuneresponses by acting as an autocrine survival factor maintainingthe viability of memory B-cells and macrophages [27]. NGFand its receptors have also tissue ... phospholipase PLCγand protein kinase C, which in turn activates the mitogen-acti-vated protein kinase pathway involving the c-jun N-terminal,the p38, and the extracellular-regulated protein kinases(ERK1/2)...

Báo cáo y học: "Hypoalbuminaemia – A Marker of Cardiovascular Disease in Patients with Chronic Kidney Disease Stages II - IV"

... major cause of morbidity and mortality in patients with chronic kidney disease (CKD) patients. Serum albumin, a negative acute-phase reactant and marker for underlying inflammation and/or malnutrition, ... CVD in early CKD stages; b) hypoalbu-minaemia may be used to identify the population at higher risk for CVD. Key words: Hypoalbuminaemia, cardiovascular disease, chronic kidney disease patients, ... suppression and increased catabolism by inflammatory cytokines (38). Cai and colleagues have implied serum albumin as potential scavenger of free radicals. Decrease in serum albumin level would lead...

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