Báo cáo y học: "Challenges in understanding Sjögren’s syndrome – improved insights into the pathogenesis generate hope for innovative therapie" ppt

... other cytokines such as BAFF/BLyS, interleukin-17, and tumor necrosis factor- alpha (TNF-α) in the context of the local production in the in amed salivary tissues. While further insight into ... blockade of the Bcell-activating factor, the role of interferon-alpha, and targeting CD22, are discussed. © 2010 BioMed Central Ltd Challenges in understanding Sjögren’s sy...

Ngày tải lên: 12/08/2014, 17:22

... compared with healthy control individuals in a study in which the Kaplan criteria were used to classify Sjögren’s syndrome [41]. Apparently, the HLA haplotype may influence the severity of autoimmune ... describing twins with primary Sjögren’s syndrome are available [2 4–2 7]. Twins exhib- ited a very similar phenotype with almost identical clinical presentation, including...

Ngày tải lên: 09/08/2014, 01:21

... pulmonary arterial hypertensio n or lung fibrosis. Table 1 presents the first disease symptom by disease category. Abnormal findings in minor salivary gland biopsy, Schirmer test and Rose Bengal stain ... Histologically, the mucosa associated lym- phoid t issu e (MALT) subtype of non-Hodgkin lympho- mas is the most commonly found. Some of the major risk factors for lymphoma develo...

Ngày tải lên: 12/08/2014, 12:20

... Defining the DUBs and their key targets that function in the DDR, as well as determining how ubiquitin affects these pathways, are important questions in the field. As the ubiquitin pathway is ... exonuclease in the repair of inter-strand crosslinks. Following DNA damage, this protein forms foci by binding the ubiquitin- conjugated form of Fanconi anemia group D2 protein (F...

Ngày tải lên: 09/08/2014, 20:21

... cystic hygromas have mediastinal extensions [5]. Isolated intrathoracic cystic hygroma is a rare finding; less than 1% of all cystic hygromas are purely mediastinal in origin. In the majority of ... and heart. In young infants with larger pure mediastinal cystic hygromas, a varying degree of respiratory compromise is the most common presenting symptom, usually secondary to extrinsic...

Ngày tải lên: 11/08/2014, 21:22

... and other cell types [99,100]. Therefore, one of the functions of MAP kinase signaling pathway may be to regulate the levels of cytokines or interleukines, thereby controlling cell mitosis in the ... ad- ipocytes. The two markers of terminal adipocyte differen- tiation – aP2, a fatty acid-binding protein, and phosphoenolpyruvate carboxykinase, an enzyme of the glyceroneogenesi...

Ngày tải lên: 13/08/2014, 13:20

... respectively. This in term may lead to therapy changes. For drugs with high therapeutic indices, therapy modifications is mainly determined by the response of the disease, whereas for drugs with low therapeutic ... tested, which easily leads to type I errors due to multiple testing. In hypothesis-based investigations, the higher probability of causality for the individual ma...

Ngày tải lên: 13/08/2014, 13:20

... suggested to inhibit TLR8 [12]. So far, the only in vivo evidence supporting TLR involve ment in the vicious in ammatory cycle in patients comes from a humanized model in which intact RA synovial ... transplanted into severe- combined immunodefi cient (SCID) mice. In this model, specifi c blockade of TLR4 markedly suppressed the spontaneous cytokine production and the...

Ngày tải lên: 12/08/2014, 15:22

... injuries were recorded in the state of Minnesota [1,2]. Nationally, there is also a rising incidence. According to the National Highway Traffic Safety Administration Fatality Analysis Reporting ... driver involved in a dMVC swerved rather than collided, was helmeted, or restrained. Spine injuries were more common in the swerve category of MCC, but injury pattern did not dif- fer w...

Ngày tải lên: 13/08/2014, 23:20

... Ageing oocyte hypotheses The cause of DS has been sought in disturbances during stages of oogenesis, including the period of meiotic arrest of the oocyte [51]. This has generated several hypotheses. ... combat infertility are increasingly being used in couples at high risk of certain genetic inherited disorders. These couples can now be reasonably assured of a normal pregnanc...

Ngày tải lên: 02/11/2012, 11:12