Báo cáo y học: "Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxiainduced mitochondrial mutagenesis in inflammatory arthritis" pot

... Access Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia- induced mitochondrial mutagenesis in inflammatory arthritis Monika Biniecka 1 , Aisling Kennedy 1 , Chin ... TNF-a may be crucial in mediating the patho- genesis of IA. TNF-a is a proinflammatory cytokine, activating the NF-B pathway, leading to a downstrea...

Ngày tải lên: 12/08/2014, 17:22

... measured by ELISA in 48-hour supernatants. Figure 3 Link between circulating tumour necrosis factor (TNF)- α bioactivity and clinical responseLink between circulating tumour necrosis factor (TNF)- α ... by cytokines in mediating cell–cell interactions in rheumatoid synovium has led to the rational development of treatment with anticytokine agents. Among these proinfl...

Ngày tải lên: 09/08/2014, 06:22

... Macrophages and T cells play a critical role in initiating and propagating the disease process. The cytokines tumour necrosis factor α (TNFα) and interleukin-1 (IL-1) mediate many of the inflammatory and ... CD11b/c followed by anal- ysis by flow cytometry. Determination of IL-17, IDO, and tryptophanyl-tRNA- synthetase (TTS) mRNA levels in antigen-sensitised cells by qR...

Ngày tải lên: 09/08/2014, 10:23

... these cells in the inflamed synovia and that blocking the effects of TNF decreases trafficking into and retention of B cells in the synovia, thereby increasing their proportion in the peripheral ... Dutcher PO, Hadley JA, Sanz I: Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid ger- minal centres...

Ngày tải lên: 09/08/2014, 14:22

... proven effective, vitamin D therapy may show promise as adjunct to anti-TNF therapy in inflammatory disease states. Abbreviations 1,25(OH) 2 D: 1,25-dihydroxyvitamin D; 25(OH)D: 25- hydroxyvitamin D; CRP: ... vitamin D receptors in tissues throughout the body. Active vitamin D is responsible for maintaining calcium homeostasis pri- marily by increasing the efficiency of intestinal c...

Ngày tải lên: 11/08/2014, 08:22

... deep accidental hypothermia, both in the operating suites and the emergency department. Introduction Deep accidental hypothermia (DAH), defined as a body temperature below 28°C, occurs infrequently, but ... resuscitation and invasive cardiology outside the operat- ing suite. In Cardiopulmonary Bypass: Principles and Practice 2nd edi- tion. Edited by: Gravlee GP, Davis RF, Utlry JR....

Ngày tải lên: 11/08/2014, 23:21

... differentiation-inducing factor- 1 [1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one]; DIF-3, differentiation-inducing factor- 3 [1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one]; ... the other hand, the activation of PI3K and Akt is involved in insulin actions to promote glucose uptake and glycolysis [25,26]. In order to assess whether PI3K and Akt are involved in...

Ngày tải lên: 23/03/2014, 09:20

... adiposity by respiratory uncoupling in adipocytes may be limited by mitochondrial oxidative capacity. Importantly, it has been sho wn in vitro [42] that the uncoupling, induced by ectopic UCP1 in ... IV and for nuclear respiratory factor- 1. Our results indicate that respiratory uncoupling in unilocular adipocytes of white fat is capable of both inducing mitochondrial biogene...

Ngày tải lên: 31/03/2014, 15:20

... deficiency results in increased circulating lysosomal hydrolases, which indicates that these molecules may be nec- essary for certain aspects of glycoprotein homeostasis [11]. Surface glycoprotein ... differentia- tion, increased baseline maturation, augmented synthesis of proinflammatory cytokines, and increased ability to promote increased proliferation and activation of allogeneic co...

Ngày tải lên: 09/08/2014, 13:22

... after the surgery, she again presented to the clinic with blurry vision. She denied any history of trauma or fall. At this time her BCVA was 20/100 in the right eye and 20/25 in the left eye. On slit-lamp ... dislocation in an RP patient one year fol- lowing posterior Nd-YAG laser capsulotomy [5]. Although there is the possibility of zonular disruption having been inflicted during sur...

Ngày tải lên: 11/08/2014, 00:22