Báo cáo y học: "Are we ready for therapeutic drug monitoring of biologic therapeutics" pot

... Lems WF: Are we ready for therapeutic drug monitoring of biologic therapeutics? Arthritis Research & Therapy 2011, 13:120. Krieckaert and Lems Arthritis Research & Therapy 2011, 13:120 ... immunogenicity certainly does play a role in the treatment of biological therapeutics. Apart from the issue of an elevated risk of side eff ects, the fi nding of antibodies...

Ngày tải lên: 12/08/2014, 17:22

... therapy for inflammatory musculoskeletal or other chronic conditions are at risk for developing symptoms of corticosteroid-induced psychosis [33-37]. Psychiatric symptoms may develop at any time ... adverse drug effects. Fragmentation and lack of coordination between pro- viders compromises patient safety and undermines qual- ityofcareandtheefficiencyofthehealthcaredelivery system [...

Ngày tải lên: 13/08/2014, 14:20

Ngày tải lên: 12/08/2014, 19:21

... difference between the proper and sham acupuncture groups [18,27]. The results of the two trials on irritable bowel syndrome were divergent [19,20]. Discussion The present study systematically reviewed ... key aspects were classified as high risk of bias or the propor- tion of information from trial s at high risk of bias was sufficient to affect the interpretation of results, the r...

Ngày tải lên: 13/08/2014, 15:21

... links between primary and foreign keys.Theselinksarenottoconveysomemeaning semantically. Semantic Web can be used to address this problem by allowing a seman tic layer to be created on top of existing ... describing different types of CM data for reproducibility, quality, and safety purposes. In the fields of genomics and pro- teomics, standards such as MIAME [27] and MIAPE [28] are a...

Ngày tải lên: 13/08/2014, 15:21

... first year of elementary/primary school (5-6 years; younger children) at all 24 schools and all families of chil- dren in grades 5-6 (10-12 years; older children) at 17 of the 24 schools were ... usual school day and usual weekend day (scale ranging from 0 to 6 or more hours, in half hour segments). School day estimates were multiplied by 5, and weekend day esti- mates were multiplied b...

Ngày tải lên: 14/08/2014, 08:20

... staining for types I and III collagens, patchy staining for type II collagen, and a little for type VI collagen. Most glycosaminoglycan staining was for chondroitin-4-sulfate, with less for keratan ... was greatest for biopsies of hyaline morphology (19.8 months) and least for those of fibrocartilage morphology (12.0 months). This suggests that the cartilage that forms initi...

Ngày tải lên: 09/08/2014, 01:21

... Ibrahim 1 1 Department of Immunology, University of Rostock, Rostock, Germany 2 Department of Neurology, University of Rostock, Rostock, Germany 3 Department of Pathology, University of Rostock, Rostock, Germany 4 Institute ... an increased frequency of memory phenotype of lpr T cells upon stimulation with collagen, phenotypic analysis of sur- face expression of CD44 on T...

Ngày tải lên: 09/08/2014, 01:23

... possibility for modulating auto-aggressive T cells in arthritis, we examined the potential of drug targeting directly to CD134 + T cells in AA by using liposomes as drug carriers. To study the ability ... antibody (mAb) as a drug targeting system. To investi- gate the possibility for therapeutic intervention in arthritis, anti- CD134 liposomes were loaded with a cytostatic d...

Ngày tải lên: 09/08/2014, 06:22

... group. Figure 2 In vivo analysis of cartilage repair by synovial mesenchymal stem cell transplantation in rabbitsIn vivo analysis of cartilage repair by synovial mesenchymal stem cell transplantation ... their quality. Stem Cells 2002, 20:530-541. 11. Sakaguchi Y, Sekiya I, Yagishita K, Muneta T: Comparison of human stem cells derived from various mesenchymal tissues: superiority of...

Ngày tải lên: 09/08/2014, 10:23