Báo cáo sinh học: " Efficient algorithms for analyzing segmental duplications with deletions and inversions in genomes" pot

... Access Efficient algorithms for analyzing segmental duplications with deletions and inversions in genomes Crystal L Kahn 1* , Shay Mozes 1* , Benjamin J Raphael 1,2* Abstract Background: Segmental duplications, ... +c-b). In a duplicate-invert operation a substring is copied from x and inverted before being inserted into the target string y. We allow the cost of i...

Ngày tải lên: 12/08/2014, 17:20

... three training methods using the linear-memory algorithms for Baum-Welch training, Viterbi training and stochastic EM training. The number of state paths that are sampled for each iteration and each ... training. In addition to introducing the two new algorithms for Viterbi training and stochastic EM training, we also examine their practical merits for three small example...

Ngày tải lên: 12/08/2014, 17:20

... the ’segregating groups’ increased between C10 and C19, C20 and C26, and C3 and C5. The proportion of F2s to backcrosses increased between C30 and C35, C40 and C44, and C50 and ... extra individual measured) increases with a. The resulting increase in size of the design required for a 70% power does not appear to be linear in...

Ngày tải lên: 09/08/2014, 18:21

... develop- ing algorithms for the variants of the MPP on multifur- cating trees. In particular, the interleaving of dynamic programming for the MPP and the greedy approach for the auxiliary matching ... also the corre- sponding maximum matchings for each Γ(chd(u)) and Γ(chd(u)\{u x })). Backtracing Backtracing for multifurcating trees proceeds in analogy to the binary case....

Ngày tải lên: 12/08/2014, 17:20

... alphabet. To handle this potential bottleneck, we introduce dummy unary nodes on each arc, in such a way that for any node μ , with Ό μ ΍ = w, and a ∈ Σ, if aw is a word of the input without a proper locus ... overall number of nodes introduced. Consider each of the origi- nal arcs in the trie in some order. For each arc, following the suffix links from the terminal nodes ident...

Ngày tải lên: 12/08/2014, 17:20

... reforms in Georgia, the public health workforce still has major problems such as irrational distribution and inadequate knowledge and skills. There is an urgent need for re-training and training ... training courses, often being a formality and/ or place for corrup- tion. Concerns were also expressed with regard to the reli- ance on donor funded episodic training courses, and...

Ngày tải lên: 18/06/2014, 17:20

... this insect insulin/insulin-like growth factor (IGF) binding protein. IInnssuulliinn//IIGGFF ssiiggnnaalliinngg aanndd IIGGFF bbiinnddiinngg pprrootteeiinnss The insulin/IGF signaling (IIS) pathway ... in Drosophila: the binding of ligands by extracellular binding proteins. In mammals, IGF-I and IGF-II are bound in vivo by IGF AAbbssttrraacctt Insulin-like growth factor (IGF) binding...

Ngày tải lên: 06/08/2014, 18:21

... origin, indicates the haplo- type origin, 1 for male and 2 for female; ψ h is the dosage compensation effect for hth haplotype allele effect and d is the dominance interaction. In this case, interaction between ... being of breed origin A, and is the probability of alleles and being IBD and being of breed origin B. is the variance of the gene effects in breed A and is...

Ngày tải lên: 14/08/2014, 13:21

... residual covariances are obtained as in the standard EM algorithm, after adjusting esti- mates of random effects for ˆα. For most algorithms, computational requirements of REML estimation in- crease with the number ... as tr  E ij R  = q  m=1 q  n=m N  k=1 tr  Σ −1 E (Δ E ij ) k Σ −1 E (Δ E mn ) k  σ Emn = q  m=1 q  n=m F E ij,mn σ Emn (6) with N the number of individuals...

Ngày tải lên: 14/08/2014, 13:22

... 35 cycles consisting of 94°C for min., 94°C for 20s, 55°C for 20s, and 72°C for 1 min. with a final extension of 5 min. at 72°C and 4°C. Publish with BioMed Central and every scientist can read ... 58°C for 30s, and 72°C for 40s, and an additional 20 cycles of 94°C for 30s, 60°C for 30s, and 72°C for 45s with an extension of 7 min at 72°C and incubation...

Ngày tải lên: 18/06/2014, 18:20