Báo cáo sinh học: "Protein sequence and structure alignments within one framework" doc

... the method handles unusual Simultaneous sequence and structure alignment of 1fa4 and 1zpuFigure 7 Simultaneous sequence and structure alignment of 1fa4 and 1zpu. Residues 22 to 105 from 1fa4 ... for Molecular Biology Open Access Research Protein sequence and structure alignments within one framework Gundolf Schenk, Thomas Margraf and Andrew E Torda* Address: Cen...

Ngày tải lên: 12/08/2014, 17:20

... scale of the packing density, and two scales of the probability of formation of backbone–backbone hydrogen bonds (assigned to donor and to acceptor residues, termed donor and acceptor scales, respec- tively). ... determines the strands and pairs with the greatest local likelihood for all of the sequence s poten- tial b-structures. betascan suggests multiple alterna- tive folding patt...

Ngày tải lên: 06/03/2014, 00:20

... SRPK1 and SRSF1, together with crystal structures of SRPK1 bound to peptide and pro- tein substrates and the recent structures of CLK1 and CLK3, suggest an elegant mechanism of recognition and ... sequential phosphorylation. X-ray structures of the kinase domains of CLK1 and CLK3 have been reported recently [41], and are G. Ghosh and J. A. Adams SRPK structure and mechanis...

Ngày tải lên: 15/03/2014, 00:20

... performed experiments. JZ and HL performed the statistical analysis and drafted the manuscript. DW and LL helped in drafting the manuscript and contributed specific information and critical analysis ... 2003, 369:1-15. 10. Meggio F, Pinna LA: One- thousand -and- one substrates of protein kinase CK2? FASEB J 2003, 17:349-368. 11. Seldin DC, Lou DY, Toselli P, Landesman-Bollag E, D...

Ngày tải lên: 18/06/2014, 19:20

... borgpetersenii; L. santarosai and L. alexanderi). Selection and validation of target genes for MLST The candidate loci sequences were obtained from the strains L. interrogans Fiocruz L1-130 and L. interrogans ... simple, and easy to standardize on an automated DNA sequencer that is more widely available in most of the laboratories and above all the sequence data generated are unam...

Ngày tải lên: 08/08/2014, 19:20

... performed sequence comparisons both, within the a-amylase locus in the D erecta strain, and between the two species, D erecta and D melanogaster. This allowed us to assess sequence ... then digested with Sal 1 and Hind III, and the Sal 1/Hind III fragments were further subcloned and inserted, in both orientations, into pIBI 24 and pIB...

Ngày tải lên: 14/08/2014, 20:20

... tissue-spe- cific environments. Oxygen and other gases, redox and nutrient conditions are likely to differ considerably both within and between tissues, and are not always the same as the controlled ... combination of dynamic NMR stud- ies and specific higher-resolution crystal structures and costructures will surely provide a wealth of informa- tion about the function of PDI and...

Ngày tải lên: 29/03/2014, 22:21

... ‘acid’ loop between the b1 and b2 strands and an 11-residue ‘basic’ loop between the a3 helix and the b12 strand (Fig. 2B). Both loops (lar- gely disordered in the crystal structures) are located ... are the ‘acidic’ and ‘basic’ loops (largely disordered in the crystal structures 1YGR and 1YGU) are shown schematically in red and blue, respectively. In the RPTPa D1 crystal structu...

Ngày tải lên: 30/03/2014, 04:20

... social and geo- graphical origins and their expectations and difficulties regarding their education and professional future. Methods A piloted, standardized questionnaire, with both definite and ... students registered completed and returned the questionnaire (see Figure 3). Their ages ranged from 18 to 36 years (median and mean of 23 years). Sixty -one percent of the respond-...

Ngày tải lên: 18/06/2014, 17:20

... purposes) sonnel policy and procedures, and produced and distrib- uted a new personnel manual to management and supervisory staff at the clinics. Personnel files were com- pleted and job descriptions ... capacity ▪ HRM budget and staff 2. HR planning ▪ organizational mission and goals ▪ HR planning 3. Personnel policy and practice ▪ job classification system ▪ compensation an...

Ngày tải lên: 18/06/2014, 17:20