Báo cáo sinh học: "A scoring matrix approach to detecting miRNA target sites" ppt

... used to assess potential targets by matching them to the miRNA sequence. These algorithms are designed to reflect molecular target recog- nition mechanisms that are assumed to apply to miRNA target ... the use of miRNA target site sequences in addition to the miRNA sequence itself to search for novel target sites. We have demonstrated its application to target...

Ngày tải lên: 12/08/2014, 17:20

... with respect to the elements of the vector y of unknowns. This can be accomplished efficiently via the Newton- Raphson algorithm. The system of equations to solve iteratively ... fixed factors (A and B) and one random factor (sire). The model used to generate records is: where a is a general mean, ai, 13j are the fixed effects of factor...

Ngày tải lên: 09/08/2014, 18:22

... Roossin. 1990. A statistical approach to machine translation. Computational Linguistics, v.16 n.2, p.79-85. Gianforte, G 2003. From Call Center to Contact Center: How to Successfully Blend Phone, ... We are thus enlightened to make use of the pho- netic mapping models, in stead of character map- ping models, to design a normalization algorithm to translate chat terms to...

Ngày tải lên: 17/03/2014, 04:20

... using the figures displayed in table 1. Coder 2 Total Topic Non-topic Coder 1 Topic 88 27 115 Non-topic 23 311 334 Total 111 338 449 Table 1: The topic annotation of Coder 1 and Coder 2. Success ... the topic in the utterance. Topic expressions were identified through a two-step procedure; 1) identifying topics and 2) determining the topic expressions on the basis of the topics. First, the topi...

Ngày tải lên: 23/03/2014, 19:20

... correspond to optimal solutions according to the SP scoring scheme. Second, we consider sets of genes known to be regulated by the same E. coli transcription factor, and apply our approach to find the ... finding algorithms can be iden- tified [25]: stochastic-search methods based on the posi- tion-specific scoring matrix (PSSM) representation and combinatorial approaches base...

Ngày tải lên: 12/08/2014, 17:20

... human cytochrome CYP1A2 are treated with the hepatotoxin and hepatocarcinogen aflatoxin B1 [52]. Thus, this uncharacterized gene may be part of a cell cycle- related response to genotoxic and/or ... In contrast, the LP-based approach to the sparse linear regression problem avoids calculation of a covariance matrix and does not require prior knowledge. Further- more, the approach pro...

Ngày tải lên: 12/08/2014, 17:20

... converted to dependency trees us- ing Stanford Parser (Marneffe et al., 2006). We con- vert the tokens in training data to lower case, and re-tokenize the sentences using the same tokenizer from ... sensitive to parser er- rors; on the other hand, integrated model is forced to use a longer distortion limit which leads to more search errors during decoding time. It is possible to 9...

Ngày tải lên: 19/02/2014, 19:20

... differences hold to a lesser degree when a partial dictionary is provided. With MLHMM, different tokens of the same word type are usually assigned to the same cluster, but types are assigned to clusters ... HHTHHHTHHH (a) (b) Figure 1: The Bayesian approach to estimating the value of a latent variable, t, from observed data, w, chooses a value of t robust to uncertainty in θ. (a)...

Ngày tải lên: 20/02/2014, 12:20

... order to achieve statistical signifi- cance. Performance over a validation set was al- ways worse with larger history sizes than 1. 5 Conclusions We have described work towards an approach to ... is to enable the quality and nature of discussions that occur within an on-line discussion board to be communicated in a summary to a potential new- comer or group moderators. We pr...

Ngày tải lên: 20/02/2014, 12:20

... sampling (Gelman et al., 2004) to approximate the posterior distribution of the hid- den variables in our model. To apply Gibbs sam- pling to our problem, we need to derive the condi- tional posterior ... the future, we plan to explore phonological context and use more flexible topological structures to model acoustic units within our framework. Acknowledgements The authors would l...

Ngày tải lên: 07/03/2014, 18:20