Báo cáo y học: "Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation" pptx

... purposes) Analysis of chloride transports in rat airway smooth muscle cellsFigure 1 Analysis of chloride transports in rat airway smooth muscle cells. A Immunofluorescence study of α -smooth muscle actin in ... transport proteins into organ physiology. We took advantage of the specific CFTR inhibitor CFTR inh -172 [23] to monitor the muscular reactivity of isolate...

Ngày tải lên: 12/08/2014, 16:20

... laboratory have shown that the inflammatory cytokines increase the expression of CD38 in human air- way smooth muscle cells [5,7,8]. The regulation of CD38 expression by TNF-α in HASM cells involves ... airway smooth muscle has a role in the regulation of airflow and in maintaining airway caliber. Airway smooth muscle contractility TNF-α-induced activation and sp...

Ngày tải lên: 12/08/2014, 15:21

... may be differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a potential role in airway inflammation. Background Allergic asthma is characterised by ... characterised by a disturbed balance between Th1 and Th2 cytokines towards Th2 dominance [1]. To test the hypothesis that Th1 and Th2 cytokines dis- played different effects on neurotrop...

Ngày tải lên: 12/08/2014, 16:20

... due to founder effects rather than being phenotypically important. Finally, in order to estimat e the st atistical significance and quantify the extent of phylogenetic clustering of the discussed ... mutations in viral protein structures of hemagglutinin (HA) and polymerase basic protein 2 (PB2). Only HA-D239G and HA-D239N appear in a position that can be rationalized to d...

Ngày tải lên: 12/08/2014, 02:20

... vulnerability of these cells to excitotoxic and oxidative injury [50]. In smooth muscle cells, homocysteine can increase production of nitric oxide [65]. However, the exact mechanism by which homocysteine exerts ... b-amyloid in Alzheimer’s disease angiopathy is produced by proliferating and degenerating smooth muscle cells. Amyloid 1, 8–10. 14. Calhoun, M.E., Burger...

Ngày tải lên: 22/02/2014, 07:20

... potential factor influencing subjective ratings, that is women show more sensitivity than men to experience emotional tone in various settings, for example, during laboratory condi- tioning procedures ... statistical analysis and drafted the manuscript. VK and GDW participated in the design of the study, helped to interpret statistical findings and to draft the manuscript....

Ngày tải lên: 09/08/2014, 01:21

... force exercised by human ASM. As previously demonstrated by us elsewhere [27], ASM cells maintain relatively high basal tone in culture that is attributable in large part to the dynamic interactions ... shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation. American Journal of Physiology-Lung Cell...

Ngày tải lên: 12/08/2014, 13:22

... sion protein was purified from the s oluble f raction b y affinity chromatography using amylose resin. In vitro kinase assays showed that the autophosphorylating ability o f PknA is strictly magnesium/manganese-dependent, ... superfamilies, histidine (His) and serine/ threonine (Ser/Thr) o r t yrosine ( Tyr) kinases, based on their sequence similarity and enzymatic specificity [1,2]....

Ngày tải lên: 22/02/2014, 04:20

... reticulum and post-translationally modulated in the Golgi apparatus, traverses into the secretory pathway towards assembling onto budding virions. We envisage that Gag by acting as cargo transport intermediate ... membrane in infected T cells and facilitate assembly is not clearly understood. Previously, Jolly and Sattentau [10] have shown that raft integrity is critical f...

Ngày tải lên: 12/08/2014, 04:21