Báo cáo y học: " Peroxisome Proliferator-Activated Receptor α (PPARα) down-regulation in cystic fibrosis lymphocytes" ppsx

... disease are cystic col- lections of mucinous material con taining varying combi- nations of mucopolysaccharides and mucoproteins within the adventitial layer of the artery. The cysts exert extrinsic ... adventitial cyst to become symptomatic involves a sufficient increase of the pressure within the fluid-filled cyst during muscle exertion, thus resulting in haemodynamically significa nt e...

Ngày tải lên: 11/08/2014, 12:20

... airway wall fibrosis. Keywords: airway fibroblasts, airway remodeling, asthma, fibronect in, geranylgeranyl transferase, statins Background Chronic o bstructive airways diseases, including asthma and ... Airway fibroblasts and myofibroblasts are a primary source of ECM proteins, including fibronectin, in subepithelial fibrosis linked to airway remodeling [7]. Targeting and understandin...

Ngày tải lên: 12/08/2014, 14:20

... those treated in the pulmonary ward of the same hospital [12], underlying that request for ICU admission is mainly trig- gered by clinical instability, the need for close monitoring or the probability for ... caused by mutations of the cystic fibrosis transmembrane conductance regulator gene (CFTR), leading to respiratory, pancreatic, and gastro- intestinal disorders [1]. Forty years ag...

Ngày tải lên: 12/08/2014, 16:20

... are increasingly being investigated, and cationic liposomes and polymers are increasingly being coupled to peptides, sugars and viral particles to try to increase gene transfer efficiency. The ... chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells. J Clin Invest 1995, 95...

Ngày tải lên: 12/08/2014, 18:20

... abnormal sweat electrolytes, sino-pulmonary disease, exocrine pancreatic insufficiency, and male infertility. Insights into genotype/phenotype relations have recently been gained in this disorder. ... RC: Cystic fibrosis gene and functions of CFTR. In Cystic Fibrosis in Adults. Edited by Yankaskas JR, Knowles MR. Philadelphia: Lippincott-Raven Publishers; 1999:3- 25. 3. Rosenste...

Ngày tải lên: 12/08/2014, 18:20

... oxygen delivery [32]. The type and volume of infused fluid can influence vascular endothelial integrity and capillary permeability [33]. Intra-abdominal compartment syndrome, intracranial hypertension, ... No 2 Rady Table 2 Common vasoactive agents used for cardiovascular support during resuscitation Type of action Drugs Inotropic Dobutamine Milrinone Dopexamine Combined Dopamine Epinephrine...

Ngày tải lên: 12/08/2014, 20:20

... glycine in physiological saline solution as well as 0.2% glycyr- rhizin, and is also combined with glutathione; and (3) the clinical indication of glycyrrhizin was clear enough (gly- cyrrhizin ... proliferator- activated receptor gamma; SOD: superoxide dismutase; Hyp: hydroxyproline; HA: hyaluronic acid; α- SMA: α- smooth muscle actins; IFN-γ: interferon-gamma; IFN -α: interferon-alfa...

Ngày tải lên: 13/08/2014, 15:21

... upregulated by endotoxin [4] and NOD-like receptor ligands [11]. Since endotoxin translocation has been reported in many different clinical settings, including pancreatitis [12], one can suggest in some ... which remains to be fully characterized. Not only do these antibodies activate monocytes and neutrophils to produce cytokines [9], but they also act in synergy with TLR4, TLR3, and...

Ngày tải lên: 13/08/2014, 16:20

... case, instead, uncertainty arises from the intrinsic impossibility of deter- mining a physical quantity that nevertheless exists (the real genome sequence present at a given instant within a living ... matrix in Fig. 1 to be com- pleted with absolute certainty for that cell. The actual genome sequence in any living cell can thus be known only with a certain amount of indeterminacy, which...

Ngày tải lên: 13/08/2014, 23:20

... E, Gaillard D: Quantitative analysis of inflammatory cells infil- trating the cystic fibrosis airway mucosa. Clin Exp Immunol 2001, 124:69-76. 2. Moss RB: Lymphocytes in cystic fibrosis lung disease: ... PPRE in peripheral lymphocytesFigure 8 Differential PPARα binding to PPRE in peripheral lymphocytes. PPARα DNA binding was analyzed via gel shift assay in periph- eral lymphoc...

Ngày tải lên: 12/08/2014, 16:20