Báo cáo y học: " Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma" ppsx
Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx
... ubiquitin target analysis and drafted the major part of the manuscript. AEL carried out the microarray analysis, ubiquitin predictions and function anal- ysis and assisted in all other aspects of the ... activity of proteases (that is, enzymes catalyzing the hydrolysis of peptide bonds) (Table 4). Protein disorder, mRNA decay rates and protein stability indices The mRNA...
Ngày tải lên: 14/08/2014, 21:20
Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... pharmacokinetics are the drug transporters and the metabolizing en- zymes [7,9]. CYP3A, the primary subfamily of the cytoch- rome P450 (CYP) enzymatic system, is responsible for the metabolism of ... 18. Hesselink DA, van Schaik RH, van der Heiden IP, et al. Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibit...
Ngày tải lên: 26/10/2012, 09:32
Báo cáo y học: " Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study" pps
... family of glutathione S- transferase (GST) in respiratory disease etiology, includ- ing that of COPD. Given their function in the metabolism of environmental toxicants as well as in the inactivation ... [53]. In other studies, the GSTP1 105Ile/Ile genotype was incon- sistently associated with COPD [13,54,58]. In vitro assays further underline the complexity of the...
Ngày tải lên: 12/08/2014, 16:20
Báo cáo y học: "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls" docx
... elucidate the role played by CD14 in the innate immune response to PG-PS in vitro and in vivo, we assessed the inflammatory responses to PG-PS in CD14 knockout primary macrophages and examined the ... level of detection, but at the peak of arthritis these cytokines were readily detectable in the wild- type mice. The expression of TNF-α mRNA was substan- tially...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Genetic and environmental influence on lung function impairment in Swedish twins" pot
... and respiratory symptoms altered the estimates differently in men and women. For FEV 1 and DLco, the variance explained by smoking and symptoms was larger in men. Further, smoking and symptoms explained ... MZ and DZ twin pairs, we can obtain information about the importance of genetic and environmental factors to the variance of the trait in question. One such measure of...
Ngày tải lên: 12/08/2014, 11:22
Báo cáo y học: " Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium" doc
... pro- tein concentration. To assess the Western analyses quantitatively, the film was digitally imaged, maintaining exposure within the linear range of detection. The con- trast was inverted, the ... to healthy nonsmokers, a finding confirmed at the mRNA level by TaqMan PCR; and at the protein level qualitatively by immunohisto- chemistry, and quantitatively by Western analysis...
Ngày tải lên: 12/08/2014, 11:22
Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... [26–37]. In a murine hyperoxia model, the effects of lisofylline on the activa- tion of NF-κB and CREB, on the expression of proinflamma- tory cytokines in the lungs and on the circulating levels of oxidized ... hyperoxia activates NF-κB in the lungs before any increase in proinflammatory cytokine protein occurs, and they further suggest that NF-κB activation may...
Ngày tải lên: 12/08/2014, 19:21
Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... lipopolysaccharide- induced proinflammatory cytokine biosynthesis in an I κκ B- αα /NF- κκ B-dependent mechanism. Evidence for the amplification of an antiinflammatory pathway in the alveolar epithelium. ... overview of the potential signaling pathways involved in cytokine-mediated regulation of hypoxia-induced hypoxia-inducible factor-1α (HIF-1α) translocation and act...
Ngày tải lên: 12/08/2014, 19:21
Báo cáo y học: "Placenta Percreta-Induced Uterine Rupture Diagnosed By Laparoscopy in the First Trimester"
... evaluated for the differential diagnosis such as appendicitis and hemoperitoneum. The gradual increase in the size of the uterus with advancing pregnancy can cause a delay in the diagnosis and appropriate ... [Rupture of the uterus in the 11th week of pregnancy]. Ugeskr Laeger. 1982;144:3836-7. 9. Singh A, Jain S. Spontaneous rupture of unscarred uterus in e...
Ngày tải lên: 25/10/2012, 10:56
Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... Wu, Vivian Y. Shin, Wallace H. L. So and Chi Hin Cho Centre of Infection and Immunology and Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China Corresponding ... investigated whether AP could protect the bone marrow and the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of th...
Ngày tải lên: 02/11/2012, 10:19