Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf

... domain has ATPase activity and facilitates self-oli- gomerization. At the amino-terminal a protein-protein inter- action mediating caspase-recruitment domain (CARD) is localized (one CARD domain ... IRAK1, IRAK2, TRAF6 as well as NIK (NF-κB-inducing kinase), TAB2 (transform- ing growth factor-β activated kinase binding protein) and TAK1 (transforming growth factor-β activated kinas...

Ngày tải lên: 12/08/2014, 16:20

... circu- lation, leading to necrosis and perforation [2]. Case presentation A 68-year-old Caucasian man presented to our hospital with acute, severe abdominal pain. An examination of the patient revealed ... was resected along with an 8 cm flange of ileum that was encompassed within the vascular terri- tory of the inflamed, unhealthy, and friable mesentery. An end-to-end seromuscula...

Ngày tải lên: 11/08/2014, 00:23

... insights into the mechanisms of protein maturation, folding, and stability Yoshihiro Sambongi 1 , Susumu Uchiyama 2, *, Yuji Kobayashi 2 , Yasuo Igarashi 3 and Jun Hasegawa 4 1 Graduate School of Biosphere ... we have gained insight into the molecular mechanisms underlying cytochrome c maturation and folding as well as stability. Bacterial cytochrome c has contributed grea...

Ngày tải lên: 24/03/2014, 03:21

... 2035 isomerization of aspartate residues [6]. Major targets of these alterations, also called Ôprotein molecular fatigue damageÕ [7], are cytoskeletal components, such as ankyrin and bands 4.1 and 4.2, as ... from L -asparaginyl deamidation and/ or L -aspartyl isomerization reactions [7]. In addition it has been reported that isoaspartate residues, detected by the PCMT in s...

Ngày tải lên: 08/03/2014, 22:20

... inflammatory diseases initiated an era of clinical investigation and estab- lished the foundation of modern clinical immunology. The original descriptions of antinuclear antibodies by Holman and Kunkel ... (RA), and vasculitic syndromes. Plasmapheresis still has an accepted role in thrombotic thrombocytopenic purpura and cryoglobulinemia; however, in other chronic inflamma-...

Ngày tải lên: 09/08/2014, 01:21

... between syno +/+ and syno +/− mice. No advanced synovial cell hyperplasia was detected in CIA-syno +/− mice, even though inflammatory cell infiltration was clearly observed in them. Detailed analysis ... functions in the ER-associated degradation (ERAD) system, an essential system for ER homeostasis. Overexpression of Synoviolin in mice causes arthropathy with synovial hyperpla...

Ngày tải lên: 09/08/2014, 07:20

... exposed at the site of overwhelming injury may act as a sink to exhaust the supply of plasma gelsolin, in turn allowing redundant inflammatory cascades unfettered opportunity to wreak havoc upon multiple ... Identified ligands include platelet- activating factor, lysophosphatidic acid, and sphingosine 1 phosphate, as well as cell-wall constituents of Gram-negative and Gram...

Ngày tải lên: 09/08/2014, 13:22

... the measuring laboratory. Statistical analysis The data were not normally distributed, so median values and interquartile ranges were calculated as measures of central tendency; the data are therefore ... follow-up and surveil- lance and often entailing changing treatments. A number of biochemical markers are currently used to clinically assess patients' disease activity, s...

Ngày tải lên: 09/08/2014, 14:22

... this article as: Siriwardana et al.: Toxoplasmosis presenting as a swelling in the axillary tail of the breast and a palpable axillary lymph node mimicking malignancy: a case report. Journal of ... presenting as a swelling in the axillary tail of the breast and a palpable axillary lymph node mimicking malignancy: a case report HP Priyantha Siriwardana 1* , Louis...

Ngày tải lên: 10/08/2014, 23:22

... and analysis of interviews. All investigators will assist with interpretation, report writing, and dissemination activities, including the culminating workshop. All inves- tigators read and approved ... research may increase knowledge about, confidence in, and greater utilization of KT processes, and the quality and quantity of KT research, perhaps ultimately leading to bet...

Ngày tải lên: 11/08/2014, 05:21