... cause of disability that affects diarthrodialjoints, being characterized by cartilage degradation, accompa-nied by local inflammation and changes in the subchondralbone. Increasing age, excessive ... Shindoh M, Higashino F, Suhara W, Koide H, Aita K,Nakagawa K, Kondo T, Asaka M, Okada F, Kobayashi M: Syner-gistic up-regulation of hexokinase-2, glucose transporters and angiogenic factors in ... housekeeping gene product as an inter-nal control. The intensity of the bands was analyzed usingImageQuant™ TL (GE Healthcare).Total RNA extraction and quantitative real-time RT-PCRTotal RNA was...