Báo cáo y học: "Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis" potx

... expo- sure. Recent data is suggesting that not only CD4 + T lym- phocytes, but also CD8 + T lymphocytes, contribute to allergen-induced airway inflammation. Depletion of CD8 + T lymphocytes prior to allergen ... coordi- nated the study and participated in drafting the manu- script. CM carried out the genotyping of cross bred mice. MS participated in the coordination of the...

Ngày tải lên: 12/08/2014, 16:20

... homo- oligomerization and nuclotidase activity. Conversely, deglycosylation might impair the E-type nucleotidase activity by weakening the monomer-monomer interac- tion and altering the tertiary and quaternary ... millimolar concentrations of Ca 2+ and electrical stimulation is linearly related to the contractile force developed in the myocardium [32]. Gramicidin S inhibits the E-NTPase...

Ngày tải lên: 13/08/2014, 22:22

... for the interest in this topic. This innovative study demonstrated the protective effect of a-lipoic acid (a-LA) administration in rat sciatic nerve crush injury by reducing the oxidative stress ... pain caused by lumbar disc herni ation that occurs with radicular pain, radiculo- pathy, or both [3]. Nerve injury may depend on length of time of crush insult. In fact,afterthetissued...

Ngày tải lên: 10/08/2014, 10:20

... cytokines and chemokines that attract leu- kocytes to the site of infection and trigger the maturation and trafficking of antigen presenting cells for induction of adaptive immunity (figure 1). The ... mediated or exacerbated in genetically predisposed individuals by infection. In some cases these infections may induce an inflammatory state that protects against asthma, while in o...

Ngày tải lên: 11/08/2014, 03:20

... tyrosine phosphorylation of beta beta- catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci USA 2000, ... cells, the binding of PTN with RPTPβ/ζ inactivates the receptor, and thus significantly increases the tyrosine phosphorylation of β- catenin [75,76]. Phosphorylated β-catenin rapidly di...

Ngày tải lên: 12/08/2014, 11:22

... [3,4]. Many authorities believe that the pathogenicity of anti-DNA antibodies is mediated by ‘indirect’ or ‘direct’ cross-reactivity. In the indirect model, the binding of anti-DNA antibodies to renal antigens ... correlation with anti-α-actinin antibodies. Although intensive efforts are being invested into developing a more targeted lupus therapy that would be, if not more effective, a...

Ngày tải lên: 12/08/2014, 11:22

... [10-15], since the vascular component of airway remodelling significantly contri- butes to the alteration of the airway wall in asthma (Figure 1). Interestingly, it has been recently shown that bronchial ... Inter- estingly, Feltis et al [47] observed cystic structures within the vessel walls, that they termed angiogenic sprouts. The number of sprouts was mar kedly increased in asth...

Ngày tải lên: 12/08/2014, 11:22

... that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of ... progression of chondrocytes from the prehypertrophic state to the hypertrophic state is negatively regulated by Notch/Delta signaling, which also controls the transition of chondr...

Ngày tải lên: 12/08/2014, 15:22

... reported that SP-D inhibits T lymphocyte proliferation and local T cell responses in vitro [30,31]. It is therefore noteworthy that we found a heavy infiltration of T lymphocytes in the vicinity of inflamed bronchioles ... for other components of both the innate and adaptive immune system to come into play. In the present study we assessed the in vivo contribution of S...

Ngày tải lên: 12/08/2014, 18:20

... of the HA) and portal injection of ATP permitted access to the arterial resistance sites. In addi- tion, antagonists of adenosine, the catabolite of ATP, although indirect, partially attenuated ... antagonist 8-SPT [26]. Our results demonstrated that both intra-arterial and intra-portal injection of ATP caused HA vasodilatation, at least in part, through activation of P 1 -pur...

Ngày tải lên: 13/08/2014, 13:20