Báo cáo y học: " Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice" potx

... asthma [28,29]. The calcium- independent iNOS is induced in a wide variety of cell types by several cytokines. NO production by iNOS is sev- eral times higher than by cNOS [30]. In the airway ... JA, Sapienza MA, Bel- lofiore S, Di Maria GU: Randomised double-blind placebo-con- trolled study of the effect of inhibition of nitric oxide synthesis in bradykinin-induced asthm...

Ngày tải lên: 12/08/2014, 16:20

... vaccination alone. The lack of response to these VLPs in our pre- vious study is probably due to the VLP dose being 1/5 of that used in this study [ 12]. Surprisingly, this 5-fold increase in ... of Molecular and Cell Biology, Faculty of Science, University of Cape Town, University Ave, Rondebosch 7701, South Africa. 2 Institute of Infectious Diseases and Molecular Medicine,...

Ngày tải lên: 11/08/2014, 08:21

... viral shedding. Background Canine influenza virus infection caused severe and acute respiratory symptoms in infected do gs [1-4]. Especially avian origin canine influenza virus was reported in Korea [2]. The ... with seven uninfected Beagle dogs. Clinical signs including fever were recorded for 14 days post inoculation. Results: The infected dog and four of seven contact dogs in the s...

Ngày tải lên: 11/08/2014, 21:21

... period. Yet, this is the first study to show the effectiveness of rapamycin in preventing pulmonary hypertension induced by a pathophysiologic stimulus. In our study, the extent of hypoxia-induced myocardial hypertrophy ... thickening of the right ventricular wall and hypertrophy of individual cardiomyocytesFigure 6 Rapamycin reverses hypoxia-induced thickening of the right vent...

Ngày tải lên: 12/08/2014, 15:20

... expression of large mucins in the lungs of mice infected by P. aeruginosa. Results: Dietary fatty acids did not influence mucin gene expression in healthy mice. Lung infection induced an increase of ... sample. Preparation of the bacterial inoculum The methodology was adapted from Cash et al. [25]. Briefly, P. aeruginosa (PAO1 strain) was incubated in 125 ml of tryptic soy bro...

Ngày tải lên: 12/08/2014, 15:20

... 10:R888-890. 60. Arcus VL, Rainey PB, Turner SJ: The PIN-domain toxin-antitoxin array in mycobacteria. Trends Microbiol 2005, 13:360-365. 61. Hayes F: A family of stability determinants in pathogenic bacteria. ... study 41869 pfam01845-CcdB Toxin of plasmid stabilization system [69] 41874 pfam01850-PIN DNA binding PIN domain, present in VapC toxins [59,60] 42429 pfam02452-PemK Toxin...

Ngày tải lên: 14/08/2014, 08:20

... fairly similar activity o n s arcosine and N-ethylglycine. In contrast, an appreciable activity on glycine, glycine-ester a nd D -pipecolic acid was only observed using GO. Interestingly, D -proline ... demethylati on of sarcosine (N-methylglycine) to form glycine and formalde- hyde. Similarly, DAAO catalyses the oxidative d eamination of neutral and (with a lower efficiency) basic D -am...

Ngày tải lên: 08/03/2014, 16:20

... monocytes and activation of the canonical inflammatory molecule, Nuclear Factor Kappa-B (NFκB). Hyperinsulinemia is a hallmark of insulin resistance and may play a key role in this inflammatory ... signaling dysregulation, significantly increased insulin plus TNFα induced VCAM-1 expression; thus, implicating the pleiotropic effects of the PI3K pathway. Finally, we not only show th...

Ngày tải lên: 11/08/2014, 03:20

... 12:12 http://respiratory-research.com/content/12/1/12 Page 2 of 12 sICAM-1 and LPS interact synergistically to increase cytokine elaboration by AMs. Taken together, these find ings imply a signi ficant, unique role for sICAM-1 in modulating the inflammatory ... and phagocytic activity of AM remain largely intact in these mice. This preservation of AM phagocytosis may reflect incompl...

Ngày tải lên: 12/08/2014, 13:22