Báo cáo y học: "Cigarette smoke exposure facilitates allergic sensitization in mice" pps
Báo cáo y học: "Cigarette smoke exposure facilitates allergic sensitization in mice" pps
... filter)(Uni-
versity of Kentucky, Lexington, KY, USA) for 7 min, 4
times a day. Carboxyhemoglobin-levels in blood were
8.29 ± 1.4% in smoke- exposed vs. 1.02 ± 0.22% in air-
exposed mice (n = 7). During air or smoke ... ovalbumin (OVA) combined with air or
tobacco smoke (4 exposures/day) daily for three weeks. Serology, lung cytopathology, cytokine
profiles in bronchoalveolar lav...
Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
... inflammatory response in the
lungs of mice which is linked to a reduction in HDAC
activity and may be a key mechanism of glucocorticoid
insensitivity in COPD [11,17,21]. Both this reduction in
HDAC ... mediated reduction in these components may
also play a role in the chronic enhanced inflammation in
diseases seen in the lungs of COPD.
Cigarette smoke- exposure induces a re...
Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... roles in disease.
In summary cigarette smoke exposure reduced HDAC-
2 activity and the expression of mSin3a and Mi-2α in the
lungs of smoke exposed mice. This may contribute to the
enhanced inflammatory ... machinery including the core
histone proteins resulting in their in re-association with
the DNA, thus presenting a transcriptionally closed con-
formation [1,16].
HDAC-2 fu...
Báo cáo y học: "Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study" pdf
...
5(4):749-756.
41. Matsunaga K, Klein TW, Friedman H, Yamamoto Y: Involvement of
nicotinic acetylcholine receptors in suppression of antimicrobial
activity and cytokine responses of alveolar macrophages ... were determined following 18 hours using immunoblotting. β-
Actin protein levels were determined as an internal control to ensure equal protein loading. Data shown is representative o...
Báo cáo y học: " Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells" pps
... Kim DY, Ryu SY, Lim KE, Lee YS, Ro JY: Anti-inflammatory mechanism of
simvastatin in mouse allergic asthma model. Eur J Pharmacol 2007,
557:76-86.
32. Kim JY, Kim DY, Ro JY: Granule formation in ... (Figure 8). This inference was confirmed by
inhibitors of Lyn an d Syk kinases, which are down-
stream kinases in FcεRI signaling pathways, and by
TGF-b receptor kinase inhibitor. This inf...
Báo cáo y học: "Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages" pdf
... that ROS play an
important role in CSM-induced TLR4 associated intracel-
lular signaling. Interestingly, we have found that CSM spe-
cifically induced phosphorylation of IRAK-1 in stably
transfected ... and
therefore protecting the cells against oxidants (indirect
effect) by modulating the redox signaling pathways
[22,23]. Thus these results indicate that CSM by inducing
ROS generation, m...
Báo cáo y học: "Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs" pot
... receptor 2 or kinase
insert domain receptor (a type III receptor tyrosine
kinase) or protein-tyrosine kinase receptor FLk-1
(VEGFR2) is key in endothelial survival and th e mainte-
nance of the ... activity of Bad by activating intra-
cellular signaling pathways that results in phosphoryla-
tion of Bad (Ser112 and Ser136) [22]. This further leads
to binding of Bad to 14-3-3 proteins and i...
Báo cáo y học: " Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice" ppt
... assayed by zymography, and net gelatinase
activity in BALF assayed by digestion of fluorescein cou-
pled gelatin, as previously described [12]. Densitometry
of zymography gels was done using ... a key factor in the lung inflammatory cell influx and
matrix breakdown seen in smoke exposed mice [38]. In
our study, influenza induced mRNA for these cytokines at
d3, with small changes in...
Báo cáo y học: " Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle" pot
... neutrophilic inflammation
in cigarette smokers, where inflammatory cytokines,
including TNFα, are usually present in the lung [28]. In
mice, TNFα appears to be a central mediator for smoke-
induced inflammation ... neutrophilic
inflammation and release of proinflammatory mediators such as interleukin-8 (IL-8). Human airway
smooth muscle cells (HASMC) are a source of proinflammatory cy...
Báo cáo y học: "Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride" ppsx
... significant pharmacodynamic interactions in
animals [8], and no pharmacokinetic interactions in
healthy human volunteers [9]. Furthermore, there are no
studies specifically investigating the interaction ... variety of clinical signs were observed in the
mice following the administration of bupropion HCl,
some of which include paralysis, ataxic gait, catatonia,
increased respiratory rate...
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