Báo cáo y học: " The role of endothelin-1 in hyperoxia-induced lung injury in mice" docx

... manifestation of the reper- fusion injury. In order to determine the usefulness of ther- apies against mast cells, it is important to know the degree to which mast cells are involved in IR injury of other ... toluidine blue staining, mast cells were easily distinguished from other cells, by their red or purple stained cytoplasmic granules respectively. In general, they we...

Ngày tải lên: 11/08/2014, 08:21

... by WSSV. The results suggested that F 1 -ATP synthase beta subunit plays a role in the WSSV infection. Conclusions F 1 F 0 -ATP synthase complexes play a central role in the synthesis of ATP in ... as the receptor for the invertebrate prokineticin, astakine, and it is located on the plasma membrane of crayfish Hpt cells [26].It will be interesting to further investig...

Ngày tải lên: 12/08/2014, 04:20

... early onset of cdk2 kinase activity [28,30]. Tax also has the abil- ity to increase cdk4 associated kinase activity in HTLV-1 infected cells by binding to p16/INK4A, resulting in the inability of p16/INK4A ... other cyclin/cdk inhibitors in that it has two cyclin binding sites, one localized within the N terminus and the other at the C terminus [20]. p21/waf1 interacts wit...

Ngày tải lên: 13/08/2014, 13:20

... cystatin A to cathepsin B, demonstrating a major role of the second binding loop of cystatin A in the inhibition of this enzyme. Pro74 may be directly involved in the interaction with cathepsin ... negligibly participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the total u...

Ngày tải lên: 17/03/2014, 10:20

... Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... the nucleophilic serine, does in uence the rate of formation of the acyl-enzyme, as judged by the effect of the mutations on the activity, but does not in uen...

Ngày tải lên: 17/03/2014, 23:20

... Matthews, R.G. & Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation of homocysteine. ... the wild-type, the EXAFS analysis unambiguously indicates that HS-CoM addition results in an increase in the number of sulfur atoms in the first coordination sphe...

Ngày tải lên: 17/03/2014, 23:20

... Taiwan; 3 Department of Pharmacy and Pharmacology, The University of Bath, UK Deacetoxycephalosporin C synthase (DAOCS) catalyses the oxidative ring expansion of penicillin N, the committed step in the biosynthesis ... these residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl si...

Ngày tải lên: 18/03/2014, 01:20

... to microbes, which play a crucial role in the maturation of the host immune system during the first years of life[4]. In addition to environmental factors, the intestinal flora may be a contributor ... strong family history of eczema, allergic rhinitis or asthma, and to their infants for the first six months after delivery. The frequency of developing atopic dermatit...

Ngày tải lên: 08/08/2014, 21:20

... Moreover, whereas the use of these drugs in the management of acute pain is typically short term (a few days to two weeks), their continuous usage in these experiments was a departure from clinical practice. Zhang ... homeostatic mechanisms, their role in bone metabolism and repair remains unclear. Review of the evidence To determine the role of COX-2 in bone repai...

Ngày tải lên: 09/08/2014, 01:21

... level of c-Myc. Also, the contribution of Ras/Raf/ERK prevented the rapid degradation of c-Myc by phosphorylation of the serine 62 residue in the N-terminal of c- Myc [24]. They also found that the ... hypothesized that c-Myc plays a central role in TGF1 signaling for cell growth stimulation. Additionally, to examine the possibility of involvement of the MAP...

Ngày tải lên: 09/08/2014, 01:22