Báo cáo y học: "CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation" doc

... purposes) Respiratory Research Open Access Research CysLT 1 receptor- induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation Saula ... [ 3 H]thymidine incorporation, EGF- R and ERK1/2 phosphorylation induced by LTD 4 or EGFFigure 5 Effect of PTX on [ 3 H]thymidine incorporatio...

Ngày tải lên: 12/08/2014, 16:20

... inflammatory sites by preferentially inhibiting proliferation of CCR6 – T cells, which include Th1 cells, but not proliferation of CCR6 + Th17 cells. Finally, prostaglandin E 2 can directly act on T cells ... prostaglandin receptor EP2-mediated and EP4- mediated signalling and cAMP pathways – induces upregu- lation of IL-23 and IL-1 receptor expression in human T cells....

Ngày tải lên: 09/08/2014, 14:22

... with atypical polyclonal proliferation and malignant lymphoma. Antican Res 1989, 9 :1457-1976. 40. Wang F, Yao K, Yin QZ, Zhou F, Ding CL, Peng GY, Xu J, Chen Y, Feng DJ, Ma CL, Xu WR: Human herpesvirus-6 ... HL and NHL as a result of lymphoma associated immunosuppression and variation in its frequency was reported [11]. In National * Correspondence: samaly183@yahoo.com 1 Virology...

Ngày tải lên: 12/08/2014, 02:20

... asthma and COPD include the production and release of chemokines and cytokines by inflammatory and structural cells [3]. Airway smooth muscle cells have recognized as immu- nomodulatory cells ... 2008, 118:3546-3556. 4. Halayko AJ, Solway J: Molecular mechanisms of phenotypic plasticity in smooth muscle cells. J Appl Physiol 2001, 90:358-368. 5. Panettieri RA Jr: Air...

Ngày tải lên: 12/08/2014, 14:20

... Table 1. Human Airway Smooth Muscle Cell culture Human airway smooth muscle (HASM) isolated from the trachealis muscle and propagated as described previously [9,10]. were used in this study. The cells ... air- way smooth muscle cells [28,29]. Recent investigations from our laboratory have shown that the inflammatory cytokines increase the expression of CD38 in hum...

Ngày tải lên: 12/08/2014, 15:21

... interaction of RV and human airway smooth muscle cells (HASM). We hypothesised that rhinovirus induction of inflammatory cytokine release from airway smooth muscle is augmented and differentially regulated ... PGE2 inhibit DNA synthesis in human airway smooth muscle cells in culture. Am J Physiol 1995, 269:L514-L519. 27. Durand-Arczynska W, Marmy N, Durand J: Cal...

Ngày tải lên: 12/08/2014, 16:20

... that human airway smooth muscle cells express and secrete MMP-12 that is up-regulated by IL-1β and TNF-α. Bronchial smooth muscle cells may be an important source of elastolytic activity, thereby ... enhanced elas- tolytic activity and excessive airway remodeling. Thus, MMP-12 induction by inflammatory cytokines may be a potential pathophysiological mechanism by which...

Ngày tải lên: 12/08/2014, 18:20

... contributors Abstract Background: Airway smooth muscle cells play a key role in remodeling that contributes to airway hyperreactivity. Airway smooth muscle remodeling includes hypertrophy and hyperplasia. It has been ... progression and airway remodeling [1]. The increase in bronchial smooth muscle, both hypertrophy [2] and hyperplasia [3], plays a critical role in...

Ngày tải lên: 13/08/2014, 13:22

... Statistical analysis Data were expressed as means ± standard devi- ations. Data were analyzed using one-way analysis of variance and secondary analysis for significance with the Turkey-Kramer post ... deficiency. At present, there is no a single medication which treats type 2 diabetes by improving both insulin resistance and insulin secretion deficiency. This study was designed to...

Ngày tải lên: 25/10/2012, 11:10

... erythrocytes either by physical methods such as endocytosis and osmosis-based systems or by chemical perturbation of the erythrocytes membrane [16]. Endocytosis is the process by which cells ... fragility of loaded erythrocyte at 2, 4, 8 mg/ml pravastatin when com- pared to that of unloaded erythrocytes (Table 4). Table 4, Erythrocyte osmotic fragility of unloaded eryth- rocytes...

Ngày tải lên: 25/10/2012, 11:10