Báo cáo y học: " Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis" ppsx

... understanding of the link between TLRs and adaptive immunity. In the present study, we are first to investigate the expression pattern of TLR1-TLR10 in cellular subsets of human tonsil T cells at ... CD4 + cells, TLR9 transcripts were down-regulated (Fig 5 ). Expression pattern of TLR transcripts in subsets of human tonsil T cellsFigure 2 Expression pa...

Ngày tải lên: 12/08/2014, 16:20

... coaxed into a Th1 phenotype by the in vitro administration of interleukin-12. This provides further evi- dence for the importance and potential clinical utility of this cytokine in vaccine development, ... considerable periods of time, and are an inefficient way to screen interesting new vaccine candidates. If true immunity is the ability to resist infection, then it is more accurat...

Ngày tải lên: 12/08/2014, 18:20

... study identifies CXCR5 as a potentially interesting therapeutic target in RA and points to the use of antagonists to this receptor as a treat- ment strategy in the disease. Materials and methods Tissue ... (SF). The inflammatory infiltrate consists pre- dominantly of B lymphocytes, T lymphocytes and macro- phages in the ST, whereas neutrophils are mainly found in the SF. The lym...

Ngày tải lên: 09/08/2014, 06:22

... of reversible ALT elevation [57]. Recognizing early symptoms of hepatic toxicity and dis- continuing treatment are important in optimizing recov- ery. Early symptoms of hepatic toxicity include apathy, malaise, ... known to affect the QT interval), high doses of antipsychotics, or symptoms possibly related to arrhyth- mias (syncope, palpitations, dizziness, etc.). The QTc interval m...

Ngày tải lên: 25/10/2012, 10:51

... clones that code for a single protein. Interestingly, during the initial process of identifying the NR family members in the A. aegypti genome, we predicted two isoforms of AaFTZ-F1, differing only ... an amino acid dependent pathway [90,91]. Hansen et al. [90] demonstrated that the TOR pathway is indeed transmitting the amino acid signal to the Vg gene in the mosquito fat body. The...

Ngày tải lên: 18/02/2014, 13:20

... to QTc lengthening [2,5-10]. The possible reasons are that the institution in this study is a university hospital where psychiatrists try to avoid tri- cyclic antidepressants which reportedly ... estimated the point prevalence of QTc prolongation in psychiatric patients in various inpatient and community settings and found that age over 65 years, use of tricyclic antidepressants, th...

Ngày tải lên: 08/08/2014, 20:23

... ially of food allergy, is agoodscreeningtesttoidentifyanindividualatriskof food allergy and the rate of allergy in a sibling of an Table 1 Clinical and laboratory data of the peanut sensitized ... published data on its incidence or prevalence. We sought to investigate the frequen cy of peanut sensitization and allergy in a group of atopic Egyptian infants and children in a p...

Ngày tải lên: 08/08/2014, 21:20

... discriminate cytokine targeting and cell targeting as the two main gene therapeutic approaches to arthritis. In cytokine targeting, the objective is to restore the (local) cytokine balance in arthritis in ... regulate the expression of rtTA and/or tTS that, only in the presence of doxycycline, can regulate the expression of the therapeutic transgene using the drug-regulable...

Ngày tải lên: 09/08/2014, 01:24

... patients. Our data indicate that NKT cells may be involved in the disease process of RA and that a strategy to boost the regulatory potential of NKT cells might be useful in the treatment of ... phenotype in RA patients, NKT cells might be functionally related to resistance or progression of RA and are therefore an interesting target for the treatment of RA. Competing interest...

Ngày tải lên: 09/08/2014, 06:22

... drug targeting system. To investi- gate the possibility for therapeutic intervention in arthritis, anti- CD134 liposomes were loaded with a cytostatic drug and administered early in actively induced ... at about this time T cells start to infiltrate the joints [17]. The present data therefore suggest that early in AA, CD134 + T cells, after activation in the PLN, can migrate to Fi...

Ngày tải lên: 09/08/2014, 06:22