Báo cáo y học: " Limited β2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics" ppt

... are in strong linkage disequilibrium with those coding for amino acid 27 in the β 2 -AR protein, which results in only a very limited variation in extended allelic haplotypes [16,18,19]. In vitro ... purposes) Respiratory Research Open Access Research Limited β 2 -adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics Anneke v...

Ngày tải lên: 12/08/2014, 16:20

... be regulated by the myc gene family members using various assays [1,27], including crosslinking [28], and cDNA microarrays [29]. Myc/Max interactions play an important role in Myc- induced transcriptional ... stimulate angiogenesis, the majority of the others, including platelet factor 4, interferon-c-inducing protein 10, IFN-2a,inter- leukin-10, interleukin-12, and interleukin-18, inhibit...

Ngày tải lên: 31/03/2014, 23:20

... phenotype. They initially show a circadian rhythm with a short period in DD, but after a few days completely lose circadian rhythmicity in behaviour [20]. Interestingly, under constant illumination ... the beginning of the dark might result from the fact that activity is induced by the light exposure and not by the culturing technique. In our case, release of SCN-AVP induced directly by...

Ngày tải lên: 10/08/2014, 09:20

... talumbu nombuto (virus/infected person); okuyina (already infected); okwayapa, yapa (somebody that is already infected) AIDS syndrome:Oshimbebe (very weak); oshinkapa (very weak or disabled); Osuvi ... HIV/AIDS in different regions Regions Typical symptoms Non-typical symptoms Caprivi Weight loss, flu or colds, fever, diarrhoea, vomiting, coughing, neck pain, thin, getting thin without be...

Ngày tải lên: 10/08/2014, 09:21

... marginated and disintegrated as shown by the electron microscope examination. The intranuclear inclu- sions were eosinophilic by Phloxine-Tartrazine stain and surrounded by a hallo and founded inside ... was proved by extramedullary haematopoiesis in which meg- akaryocytes observed in hepatic sinusoids, lymph nodes and splenic sinusoids [22]. The clinical results also revealed a significa...

Ngày tải lên: 12/08/2014, 04:21

... well-documented signaling cas- cade is initiated resulting in activation of adenylyl cyclase, cyclic AMP formation, protein kinase A (PKA) activation and ultimately airway relaxation [4]. In addi- tion ... of clinically relevant agonists in human primary ASM (hASM) cells by using a modified Epac protein fused to CFP and a variant of YFP. Methods: Cells were imaged in real time using...

Ngày tải lên: 12/08/2014, 13:22

... protein analogue poly-L-arginine inhibits L-arginine uptake [37] and causes airway hyperreactivity to metha- choline in perfused guinea pig tracheal preparations by causing a deficiency of agonist- induced ... reversed by L-NNA, demonstrating that argin- ase activity attenuates iNANC nerve -mediated airway smooth muscle relaxation by limiting NO production. Since arginase activity in...

Ngày tải lên: 12/08/2014, 16:20

... poorly understood. Ex- posure to allergen causes an increase in airway responsive- ness that is associated with an influx of inflammatory cells, particularly eosinophils, into the airways in allergic humans ... necessary to completely in- hibit their infiltration into the lung before any impact on AHR is observed. Increased levels of macrophages, mono- cytes and lymphocytes in the l...

Ngày tải lên: 12/08/2014, 18:20

... may not be the main site of inflammation in asthma, but inflammation in asthma extends from the larynx to the terminal bronchioles and the tracheal mucosa certainly appears inflamed in many asthmatic ... the inducible form of NO synthase (iNOS) and therefore may reflect air- way inflammation, alternatively NO maybe produced by the bronchial epithelium. In addition the activity of iNOS...

Ngày tải lên: 12/08/2014, 18:21

... nitrogen washin-washout technique. (a) The relation between the EELV measured by increasing the FiO 2 as a function of the EELV obtained decreasing FiO 2 . The EELV obtained increasing the FiO 2 was ... multiplied by the EELV obtained decreasing the FiO 2 (r 2 = 0.84, p < 0.0001). (b) The Bland-Altman plot of the EELV measurement obtained increasing the FiO 2 and the EELV obtained decreasi...

Ngày tải lên: 13/08/2014, 16:20