Báo cáo y học: " Differential regulation of neurotrophin expression in human bronchial smooth muscle cells" pptx

... may be differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a potential role in airway inflammation. Background Allergic asthma is characterised by ... airway hyperreactivity in animal studies [12-14], they may have distinct roles in allergen-dependent airway obstruction [24]. Hence, NGF may play a role in the early airway response (EAR) in...

Ngày tải lên: 12/08/2014, 16:20

... file 2Results of confirmatory RT-PCR analyses verifying differential expression of selected transcriptsResults of confirmatory RT-PCR analyses verifying differential expression of selected transcripts.Click ... other indications of immune activation emerged in the set of over-expressed genes, including pro- inflammatory cytokines, chemokines, granzymes, protein- ases, an...

Ngày tải lên: 14/08/2014, 08:20

... Eyk JE: cGMP- mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery. Journal of Physiology-London ... changes in cell stiffness as measured by magnetic twisting cytometry. Function efficacy of small molecules on stiffness of ASM at the level of a single living cell. Figure S2:...

Ngày tải lên: 12/08/2014, 13:22

... n = 4. C Immunofluorescence study of CFTR in TSMC and D in the absence of primary antibody. α -smooth muscle actin is stained in red, CFTR in green and nucleus (TOPRO-3 staining) in blue. Scale ... to airway smooth muscle in CF. They shown increased smooth muscle con- tent of the airway in subjects with CF compared to healthy controls. This increase is due to s...

Ngày tải lên: 12/08/2014, 16:20

... access [14]. In contrast to all Fe-hydrogenases including HydA of S. obliquus,the enzyme of C. reinhardtii has an interesting additional protein domain. A small insertion of 45 amino acids between ... synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA of C. reinhardtii, the first isolated gen...

Ngày tải lên: 08/03/2014, 22:20

... Alternatively, hTR and hTERT may play a minimal catalytic activity in telomerase, while the assembly of other telomerase subunits may amplify the enzyme function. In this scenario, deletion of mTEP1 in embryonic ... of dyskerin, although showing comparable inhibition of telomerase function in cells, exhibited a weaker inhibition of telomerase activity in the in vitro ass...

Ngày tải lên: 17/03/2014, 23:20

... identify the DGK isoforms in the right atrial myocardium in patients undergoing cardiac surgery with cardiopulmonary bypass and (2) to examine changes in expressions of DGK isoforms in cases of failing ... protein kinase C, in the development of heart failure. DAG kinase (DGK) acts as an endogenous regulator of GPCR signaling pathway by catalyzing and regulating DAG. Express...

Ngày tải lên: 10/08/2014, 09:21

... this may be the case for the GM-CSF promoter in alveolar macrophages from smokers [46]. Also another interest- ing study investigating the effect of pro-inflammatory cytokines in intestinal alkaline ... mode of action of butyrate in IBD, where for example reports show that butyrate inhi- bits NF-B activation and increases IBb levels in vitro in intestinal epithelial cell lin...

Ngày tải lên: 11/08/2014, 03:20

... interest- ing study investigating the effect of pro-inflammatory cytokines in intestinal alkaline phosphatase (IAP) gene expression comes to further support the possible role of histone acetylation ... is involved in pro-inflammatory cytokine gene transcription, is increased in the intestinal mucosa o f CD patients [31]. Modulation of histone acetylation is involved in tran- s...

Ngày tải lên: 11/08/2014, 06:22

... Models including the exon 6 indel were clearly inferior and are not shown, given the lack of any previous evidence of the involvement of the exon 6 indel in IRF5 cis -regulation. Each of the remain- ing ... available in the asthma collection of LCLs. Table 1 Expression profiling studies in lymphoblastoid cell lines whose IRF5 data have been analysed a Study Number of LCLs...

Ngày tải lên: 12/08/2014, 15:23