Báo cáo y học: "EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-β signaling in lung fibroblasts" doc

... significantly inhibited by EM703 (Figure 6). The mechanisms of inhibition by EM703 of bleomycin- induced pulmonary fibrosis in mice may involve the inhi- bition of TGF-β signaling, mediating fibroblast ... assessment of pulmonary fibrosis on day 28 after bleomycin injection in ICR mice by the Ashcroft score (n = 8) (a). Comparison of hydroxyproline...

Ngày tải lên: 12/08/2014, 16:20

... point to an important role in inflammation[9]. Pro-inflammatory signaling mediators such as IL-1 and TNF-α induce the synthesis of PGE2 by promoting the expression or activities of cyclooxygenase ... difference in the results. In the present study, the abnormal stress on cartilage tissues induced by joint instability was the main cause of degeneration. The...

Ngày tải lên: 12/08/2014, 18:20

... survival b,c,h The number in parentheses indicates the outcome of the second pulmonary resection d,e,f,g The common outcome from both the first and second pulmonary resections i Another pulmonary micrometastasis ... ases of pulmonary metas- tases from esophageal carcinoma. The primary treat- ments were surgery alone (53%), radiotherapy alone (4%), combined modality t...

Ngày tải lên: 10/08/2014, 09:22

... that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the ... previously that G/G of the PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18]. The present study examined the associat...

Ngày tải lên: 31/10/2012, 15:37

... increase from the apoenzyme to the Mn 2þ -containing enzyme, loss of the metal cofactor could be the limiting step in BLXI inactivation. Higher E a values of inactivation for the Co 2þ – enzyme and the ... on xylose, the apoenzyme activity was tested on both sugars in the presence of increasing concentrations of each cation (in the chloride form; Fig. 4). In...

Ngày tải lên: 22/02/2014, 07:20

... profound inhibition of protein syn- thesis. In each case this was accompanied by dephosphory- lation of the eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and increased binding ... Enhanced Chemiluminescence (ECL) system (Amersham plc). Other assay procedures Rates of protein synthesis were assayed in CHO.K1 cells by measuring the incorporation of [ 35...

Ngày tải lên: 18/03/2014, 01:20

... out in the presence of increasing concentrations of Ca 2+ calmodulin, the inhibition dropped by  50% in each case. In addition, these peptides also inhibit the activity of calcineurin, another enzyme ... with Ca 2+ calmodulin, they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1, frenatin 3 and caerin 1. 9, all inhi...

Ngày tải lên: 31/03/2014, 15:20

... of many MMPs increases in OA by either an increase in their own synthesis, an increased activation by their proen- zymes, or decreased activity of their inhibitors [29]. Pro- inflammatory cytokines, ... and bradykinin synthesis, since HA inhibited their synthesis in a MW-dependent manner [16]. Further, HA has been shown to induce analgesia in a bradykinin-induced model of jo...

Ngày tải lên: 09/08/2014, 01:21

... A blinded set of serum samples was therefore analyzed in Hanover. Results Analysis for anti- αα -fodrin, anti-La, and anti-Ro60 by ELISA Using the purified α-fodrin–GST protein encoded by the cDNA ... autoimmune exocrinopathy of unknown origin. Therefore the diagnosis of SjS, in the absence of a gold standard, is based on cri- teria containing a number of subjective...

Ngày tải lên: 09/08/2014, 01:23

... reported have included periosteal hypertrophy, ablation, uneven cell distribution, and loss of cells into the joint cavity [15,16], resulting in repetition of surgery in up to 25% to 36% of patients ... Despite these advances, most surgical inter- ventions only result in improvement in clinical symptoms, such as pain relief, and the regeneration of long-lasting hyaline car...

Ngày tải lên: 09/08/2014, 10:21