Báo cáo y học: " Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells" docx

... in human pul-monary artery smooth muscle cellsFigure 1 Phosphodiesterase type 4 (PDE4) expression in human pulmonary artery smooth muscle cells. RT- PCR demonstration of PDE4A ( 546 bp), PDE4B ... ng/ml). PDE inhibitors and/ or prostacyclin analogues were added 30 45 min before the addition of mitogen and [ 3 H- methyl]-thymidine and the incorporation of thy...

Ngày tải lên: 12/08/2014, 16:20

... to baseline levels of selected variables reflecting renal function, including creatinine clearance, level of 24- hour urinary protein excretion, serum albumin, activity index score, chronicity index score, ... tubular atrophy). In the much smaller cohort of the present study, only a chro- nicity index score ≥ 4 and a index score for interstitial fibrosis ≥ 2, i.e., histological findings...

Ngày tải lên: 09/08/2014, 10:23

... can also be induced in BIV infected FBL cells. Taken together, bISG15 is an antiviral and inducible protein in BIV infected FBL cells. Finding Type I IFNs' binding to cell type specific ... ISG15 and its conjugation modification play roles in processes including regulation of IFN signal- ing, innate immunity, anti-viral infections, pregnancy, and carcinogenesis [4] . Int...

Ngày tải lên: 12/08/2014, 04:20

... proteins. This was particularly noticeable with proteins involved in cell growth and maintenance (for example, fibrinogen γ chain (FGG) and ubiquinol cytochrome c) and cell-cell interaction and integrity ... systems for studying mDC biology. For instance, DCs can be generated in vitro from peripheral blood monocytes by culturing them for six days in the presence of interleukin (...

Ngày tải lên: 14/08/2014, 18:20

... embrane [41 ]. Finally, in h eart muscle, R ab11A is found together with Rab4 in the insulin-mobilized vesicles containing the glucose trans- porter (GLUT4) and could therefore play a role in the fusion ... roles in the constitutive and r egulated pathways of exocytosis [41 ,44 ,45 ]. Rab11A is f ound in the trans-Golgi network and in vesicles and granules derived theref...

Ngày tải lên: 08/03/2014, 16:20

... activity and inhibits apoptosis in pulmonary artery smooth muscle cells. Apoptosis 2009, 14: 42-51. 11. Wang LN, Wang C, Lin Y, Xi YH, Zhang WH, Zhao YJ, Li HZ, Tian Y, Lv YJ, Yang BF, Xu CQ: Involvement ... systemic and pulmonary circulation in physio- logical and pathophysiological conditions. For example, coronary artery is relaxed but pulmonary artery is con- t...

Ngày tải lên: 10/08/2014, 05:21

... adequate staging of Stage II and III colon cancer. Journal of Hematology & Oncology 2011, 4: 25. 4. Javle Milind, Hsueh Chung-Tsen: Recent advances in gastrointestinal oncology - updates and insights ... Surgery, Henan Provincial Cancer Hospital, Henan Provincial Institute of Cancer, Zhengzhou, Henan Province, China. Authors’ contributions YL and SY designed the study, interpret...

Ngày tải lên: 10/08/2014, 21:23

... 37. 54 0.9 94 IL-12P40 Y = -3.36X + 36.05 0.995 IL -4 Y = -3.16X + 39 .42 0.991 IL-5 Y = -3.74X + 40 .46 0.995 IL-13 Y = -4. 02X + 40 .87 0.991 IL-10 Y = -3.53X + 37.18 0.991 H strain Ts strain Y = -3.50X ... economic l oss in the poultry industry [1]. IBDV can be differentiated into two serotypes (sero- type 1 and 2) [2]. Serotype 1 shows different degrees of pathogeni...

Ngày tải lên: 11/08/2014, 21:21

... different cell types present in arthritic joints can produce PAs and their inhibitors in vitro, inclu ding in response to inflam- matory cytokines [4- 11]. We and other workers have previously reported ... receptor for human C5a anaphylatoxin. Nature 1991, 349 :6 14- 617. 32. Vlasenko LP, Melendez AJ: A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, p...

Ngày tải lên: 12/08/2014, 11:23

... 8:15 http://www.clinicalmolecularallergy.com/content/8/1/15 Page 8 of 11 may possibly be involved in determining that the protein is an allergen by determining when the protein comes into contact with the immu ne system for ... were centrifuged for 20 min at 800 × g at room temperature in a swinging bucket rotor centrifuge and the buffy coat layer containing monocytes and lymphocytes...

Ngày tải lên: 13/08/2014, 13:22