Báo cáo y học: "onsidering comorbidity in managing rheumatic diseases: going where trials cannot go" potx

... comorbidities in certain rheumatic diseases. Although these reviews do not © 2010 BioMed Central Ltd Considering comorbidity in managing rheumatic diseases: going where trials cannot go Daniel Aletaha* ... erapy on ‘Treating rheu matic patients with a malignancy’ [4], is exemplary in support- ing this motivation: malignancy, even ‘just’ by history, is a major challe...

Ngày tải lên: 12/08/2014, 15:23

... [55]. Cell sources for tissue engineering in rheumatic diseases Today, autologous chondrocytes represent the only cell type routinely used for joint cartilage repair. In the future, autolo- gous or ... purpose, 3D in vitro high-density chondrocyte pellet and alginate cultures help to preserve/regain the chondrocyte phenotype following monolayer expansion by offering cell-cell and cell...

Ngày tải lên: 09/08/2014, 01:22

... Heijde D, Bellamy N, Calin A, Dougados M, Khan MA, van der Linden S: Assessments in Ankylosing Spondylitis Working Group. Preliminary core sets for endpoints in ankylosing spondylitis. J Rheumatol ... treatment in the inflammatory rheumatic diseases nowadays has become reaching and sustaining remission. Clinical remission, meaning absence of clinically visible disease manifestations,...

Ngày tải lên: 09/08/2014, 14:22

... healthy controls, OA = osteoarthritis, MFP = patients with myofascial pain, , NE = norepinephrine, EPI = epinephrine. Table 2: Autonomic function in patients with systemic inflammatory rheumatic ... with an increase in IL-6 levels [65]. A recent meta-analysis showed IL-6 levels to be consistently increased after psy- chosocial stress in healthy individuals [16]. The contra- dictory f...

Ngày tải lên: 12/08/2014, 12:20

... phenom- enology and family history study. Am J Psychiatry 1985, 142:441-446. 14. Kirmayer LJ, Robbins JM, Kapusta MA: Somatisation and depres- sion in fibromyalgia syndrome. Am J Psychiatry 1988, 145:950-954. 15. ... HC were included if they reported no history of psychiatric disorder, reported no distribution of pain intensity and scored nine or lower on the Beck Depression Inventory [24]...

Ngày tải lên: 08/08/2014, 21:20

... to target key cytokines implicated in JIA, including TNFα, IL-1, IL-6 as well as signaling molecules involved in the regulation of B-cell and T-cell lymphocyte responses (Table 4). Although promising ... Wallace CA, Chon Y, Lin SL, Baum- gartner SW, Giannini EH, Pediatric Rheumatology Collaborative Study Group: Safety and efficacy of up to eight years of con- tinuous etanercept therapy...

Ngày tải lên: 09/08/2014, 01:22

... and infliximab shown in this study [12]. In a small study, anti-infliximab antibody developed more commonly in non-responders and in patients who had infusion reactions [44]. In a recent study ... way in which productivity is valued, the costs of infliximab could be compensated for by savings in productivity [48]. Another study reviewing costs in early inflammatory disease fou...

Ngày tải lên: 09/08/2014, 10:20

... differences, differences in environmental exposures or a combination of both. With increasing obesity, gout is becoming endemic in China. Finally, symptomatic knee osteoarthritis is extremely common in China and ... are usually presented, whereas age-standardized prevalence would often be more informative, especially since rheumatic diseases vary in prevalence by age. An additional...

Ngày tải lên: 09/08/2014, 10:22

... models Cary, NC: SAS Institute Inc; 1996. 27. SAS Institute Inc: SAS OnlineDoc 9.1.2 Cary, NC: SAS Institute Inc; 2004. 28. Singer JD, Willett JB: Applied longitudinal data analysis: Modeling change and ... N, Shibuya M, Fukami Y: Genistein, a specific inhibitor of tyrosine- specific protein kinases. J Biol Chem 1987, 262:5592-5595. 47. Kelley DS: Modulation of human immune and inflammator...

Ngày tải lên: 11/08/2014, 08:22

... division; they transduce synovium very effectively after intra-articular injection [12,13]. Although lentiviruses are being engineered to remain episomal, their human use in rheumatology seems unlikely ... in clinical trials, they are less relevant to rheumatic diseases. Herpes simplex virus, for instance, is still troubled by cytotoxicity and its use is increasingly restricted to the...

Ngày tải lên: 09/08/2014, 01:22