Báo cáo y học: "Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor b pathway in patients with systemic sclerosis" pot

... intensity by IgG from SSc patients were analysed by using Pathway Studio soft- ware. Interestingly, most of < /b> these proteins < /b> were involved < /b> in < /b> the < /b> transforming < /b> growth < /b> factor < /b> b (TGF -b) pathway (Additional ... this article as: Bussone et al.: Identification of < /b> new < /b> autoantibody < /b> specificities < /b> directed < /b>...

Ngày tải lên: 12/08/2014, 15:23

... several of < /b> the < /b> RI lines, thereby retaining the < /b> phenotype of < /b> parental C57BL/6.NOD-Aec1Aec2 mice, while a number of < /b> the < /b> RI lines also failed to show a loss of < /b> secretory activities, thereby indicating ... balance of < /b> IL-6 and transforming < /b> growth < /b> factor-< /b> beta influenced by retinoic acid. Thus, the < /b> intricacy and bala...

Ngày tải lên: 09/08/2014, 13:22

... and the < /b> cellular cytotro- phoblasts, the < /b> labeling profile is compatible with syncytin- Ory1 being expressed in < /b> the < /b> cytotrophoblast just before fusion takes place and/or in < /b> the < /b> newly formed syncytio- trophoblast ... transduced with syncytin-Ory1. Finally, in < /b> situ hybridization of < /b> rabbit placenta sections with a syncytin-Ory1 probe r...

Ngày tải lên: 12/08/2014, 23:22

... clinical history, and certain laboratory data may guide the < /b> choice of < /b> which endoscopic in < /b> - vestigation to perform first in < /b> patients with IDA, the-< /b> reby, potentially reducing the < /b> frequency of < /b> ... endoscopic investigation to perform first in < /b> patients with IDA (especially in < /b> pre-menopausal women), thereby, potentially redu...

Ngày tải lên: 25/10/2012, 11:18

... prey protein interacts with the < /b> bait protein, this would bind the < /b> NubG and Cub domains together to form the < /b> ubiquitin complex. This complex will then be recognized by UBPs and the < /b> TF that ... system is not suitable for the < /b> analysis of < /b> interaction between membrane bound proteins.< /b> The < /b> split-ubiquitin yeast two hybrid system has be...

Ngày tải lên: 02/11/2012, 11:08

... indicating that the < /b> subpopulations – although exhibiting considerable overlap – are not absolutely identical. The < /b> expression of < /b> triple com- binations of < /b> MPC typical surface markers, combined with the < /b> ... were incubated with 10 ng/ml recom- binant human transforming < /b> growth < /b> factor-< /b> β 3 (Tebu, Offenbach, Germany) during chondrogenesis....

Ngày tải lên: 09/08/2014, 01:23

... no inhibiting effect of < /b> the < /b> SmD3 peptide on the < /b> binding of < /b> anti- Sm antibodies to the < /b> native Sm antigen in < /b> ELISA (Varelisa ® Sm; data not shown). The < /b> absence of < /b> inhibition can be explained by the < /b> ... peptide synthesis, non- specific binding sites were blocked by overnight incubation of < /b> the < /b> membranes in < /b> blocki...

Ngày tải lên: 09/08/2014, 06:22

... of < /b> the < /b> kinesin-binding domain is very probably the < /b> most conservative form of < /b> kinectin; it does not bind kinesin but act as a membrane anchor for the < /b> transla- tion elongation factor-< /b> 1 delta in < /b> the < /b> ... that are large coiled- coil rich proteins < /b> (≥100 kDa) in < /b> the < /b> cytoplasm. Conclusion Here we report the < /b> detection...

Ngày tải lên: 09/08/2014, 07:20

... cell lysates were extensively deiminated in < /b> vitro. This is demonstrated by the < /b> uniform migration of < /b> deiminated enolase at < /b> a pI of < /b> 5 and by the < /b> replacement of < /b> arginine by citrulline in < /b> all the < /b> peptides ... although the < /b> intensity of < /b> the < /b> staining indicated that levels of < /b> citrullination were relatively low...

Ngày tải lên: 09/08/2014, 07:20

... is frequently seen in < /b> the < /b> joints of < /b> patients with RA [27,29], indi- cating that the < /b> gene expression profiles obtained from these RA models well represent those of < /b> patients with RA. In < /b> addi- tion, many of < /b> ... alternative pathway of < /b> the < /b> complement system. This pathway is also critical in < /b> K/BxN mice, another animal...

Ngày tải lên: 09/08/2014, 08:22