Báo cáo y học: "Regulation of chondrocyte gene expression by osteogenic protein-1" ppt
Báo cáo y học: "Regulation of chondrocyte gene expression by osteogenic protein-1" ppt
... signifi-
cance of differentially expressed genes, a gene ontology
analysis was conducted using DAVID/EASE [12].
Pathway analysis and classification by gene ontology
Regulated genes (R > 1.5-fold, ... input-genes occur randomly within
this pathway. Grouping of genes was done by computing
over-rep resentati on of regulated genes in gene ontology
(GO) classes [14]. Statistical...
Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
... directly and by gene therapy inhibits
matrix degradation in the intact degenerate human interverte-
bral disc: an in situ zymographic and gene therapy study.
Arthritis Res Ther 2007, 9:R83.
14. Hoyland ... non-parametric, they were then analysed
by the Mann-Whitney U test.
Results
Effect of cytokines on matrix-degrading enzymes
There was no difference in the basal levels of gene...
Báo cáo y học: "Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients" pptx
... marked by aster-
isks (*).
Figure 3
Gene expression pattern of chondrocytes after first passage (P1 )Gene expression pattern of chondrocytes after first passage (P1). Chondrocytes from cartilage of ... strongly (1,448-fold) after 10 to 12
days of in vitro culture to expression levels only slightly higher
than the IL-1β expression of healthy chondrocytes ex vivo or of...
Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation doc
... the
Prime-a -gene labeling system (Promega). Double-positive
clones were purified by secondary and tertiary r ounds of
screening and genomic DNA inserts were purified using
poly(ethylene glycol) precipitation ... upstream of the luciferase gene, a nd the resulting
plasmid constructs were transiently transfected into cultured
cells. In view of the relatively low efficiency of transfec...
Báo cáo Y học: Prediction of temporal gene expression Metabolic optimization by re-distribution of enzyme activities ppt
... depletion of
glucose is accompanied by concerted changes in the mRNA
levels for most enzymes of the central metabolism of yeast
resulting in down-regulation of glycolysis and up-regulation
of the ... regulation; gene expression.
Microarray technologies provide the means to measure
simultaneously the expression patterns of thousands of
genes [1,2]. These expression data...
Báo cáo Y học: Regulation of peptide-chain elongation in mammalian cells pptx
... ADP-ribosylated by diphtheria toxin
[25]. ADP-ribosylation inhibits the activity of eEF2.
Phosphorylation of eEF2 inhibits its activity, in translo-
cation and in poly(U)-directed polyphenylalanine synthesis
[26,27], ... the phosphorylation of the valyl-tRNA synthetase
that associates with eEF1A/B. The available evidence
suggests that phosphorylation of eEF1A/B and of valyl-
tRNA...
Báo cáo Y học: Regulation of mammalian translation factors by nutrients pot
... Thr70, the sites most profoundly
affected by rapamycin, may be regulated by nutrients
through the mTOR pathway.
REGULATION OF 4E-BP1 BY AMINO
ACIDS
In a number of kinds of mammalian cells, amino ... the
control of eIF4E (by 4E-BP1) for the activation of protein
synthesis by amino acids [92]. In isolated rat heart cells
(ventricular myocytes), protein synthesis is acutely ac...
Báo cáo y học: " Impairment of chondrocyte biosynthetic activity by exposure to 3-tesla high-field magnetic resonance imaging is temporar" pptx
... (0.9 ± 0.27 ng/ml per µg of hydroxyproline)
and the 'pulsed EMF' group (0.9 ± 0.37 ng/ml per µg of
hydroxyproline).
Impairment of chondrocyte activity induced by the 3-
tesla EMF is transient
According ... proteoglycan synthesis of human
articular chondrocytes: the role of nonenzymatic glycation.
Arthritis Rheum 1999, 42:1003-1009.
48. Schafer SJ, Luyten FP, Yanagishit...
Báo cáo y học: "Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes" pps
... Firestein
GS: Cytokines in chronic inflammatory arthritis. VI. Analysis of
the synovial cells involved in granulocyte-macrophage colony-
stimulating factor production and gene expression in rheuma-
toid ... J, Koyama Y, Majima T, Aoki Y, Ichiyama H,
Ishibashi T, Minami A: Macrophage migration inhibitory factor
up-regulates the expression of interleukin-8 messenger RNA
in synovial...
Báo cáo y học: " Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways." ppt
... induc-
tion of IκBα in the IκBα-luc transgenic mice by LPS. We
demonstrated involvement of both the NF-κB and the p38
MAP kinase signaling pathways in the induction of IκBα
expression by LPS.
Clinically, ... regulation [9].
Induction of IκBα-luc expression in the early stage of the
LPS response is consistent with a tight auto-regulation of
the NF-κB signaling pathway by...