Báo cáo y học: "Osteoarthritis subpopulations and implications for clinical trial design" pptx

... subheadings phenotypes, struc- tural and symptomatic stage, co-morbidity, and patient characteristics. Finally, we searched for more detailed information on these (kind of ) subpopulations and for examples ... lesser degree for hip OA and hand OA, and probably acts through a change in load distribution in the knee [72], and systemic and local inflammatory cytokines [...

Ngày tải lên: 12/08/2014, 15:22

... self-perceived health and well-being were evaluated by applying the Fibromyalgia Impact Questionnaire, the Brief Pain Inventory, and the European Quality of Life five-item questionnaire. For many years there ... urgent need both for more research (including pathophysiology and epidemiology) and for the acceptance of emerging treatment challenges. Despite the increasing awareness...

Ngày tải lên: 09/08/2014, 14:21

... medium: 51-70, and high: 71-100). Age at military entry was dichotomized based on the mean of the distribution (<19, ≥19 years). Deployment information included dates and country of deployment. Individuals ... psychiatric or PTSD diagnosis, anditislikelythatadditionalpersonnelhadsymptoms without an official clinical diagnosis. Also, combat deployers are likely made aware of and enc...

Ngày tải lên: 11/08/2014, 16:22

... justified by the results of this exploratory study) by identifying the key cost driv- BIPED Trial DesignFigure 1 BIPED Trial Design. TAU: Treatment as usual Recruitment from Cardiff Primary Care ... prevention and early intervention; vi) psychological approaches; vii) gender-specific considera- tions and viii) advice for family and carers. The 8 modules are delivered online on...

Ngày tải lên: 11/08/2014, 17:20

... CIDE3 (positive) and CDK (negative). (b) Controls for the proliferation assay are cyclin A (positive) and YFP (negative). (c) Controls for the MAPK assay are DUSP10 (positive) and YFP (negative). ... 3) and the Fas receptor, and the negative control were vectors expressing cyclin-dependent kinase and YFP. Positive and negative controls for the proliferation assay were vec...

Ngày tải lên: 14/08/2014, 17:22

... complexity into biological context. Being able to accurately survey sequence variation and gene activity simultaneously should enable a single experiment to yield large amounts of diverse informa- tion: ... sequences have always been excluded from array probe designs for this very reason, and these elements can now be profiled using RNAseq. http://genomebiology.com/2008/9/9/234 Genome B...

Ngày tải lên: 14/08/2014, 20:22

... clinical trial. Evaluations of physical activity and pain scores, serum biochemistry, hematology, and urine biochemistry were done at baseline (day 0) and on days 7, 30, 60 and 90 during follow up. ... (n=20) daily for 90 days. Each patient was evaluated for pain and physical functions by using the standard tools (visual analog scale, Lequesne's Functional Index, and...

Ngày tải lên: 25/10/2012, 11:40

... Ageing of lymphocytes and lympho- cytes in the aged. Immunol Today 2000, 21:515-521. 55. Timm JA, Thoman ML: Maturation of CD4 + lymphocytes in the aged microenvironment results in a memory-enriched ... of antibody avidity. Immunology 1978, 35:601-611. 75. Nicoletti C, Yang X, Cerny J: Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphoryl- choline ant...

Ngày tải lên: 09/08/2014, 01:23

... autoreactive lymphocytes trigger macrophages, synoviocytes and other effector cells that mediate synovitis and the destruction of cartilage and bone [1–7]. B and T lymphocytes in rheumatoid arthritis and ... experimental and clinical data strongly support the possibility that autoreactivity against systemically expressed autoantigens may result in organ-specific autoimmune disea...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 07:20